Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/FcεRI receptor mediated mast cell leukotriene release

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 6, 2003, Pages 1095-1105

  Venkatachalam, T K ^a   Qazi, S ^a   Samuel, P ^a   Uckun, F M ^a,b,c  

^a PARKER HUGHES INSTITUTE   (United States)

^b Drug Discovery Program   (United States)

^c Parker Hughes Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; HETEROCYCLIC COMPOUND; IMMUNOGLOBULIN E RECEPTOR; LEUKOTRIENE; N [1 (1 NAPHTHYLETHYL)] N' [2 (4 METHYLTHIAZOLYL)]THIOUREA; N [1 (1 NAPHTHYLETHYL)] N' [2 (5 METHYLPYRIDYL)]THIOUREA; N [1 (1 NAPHTHYLETHYL)] N' [2 (BENZOTHIAZOLYL)]THIOUREA; N [1 (1 NAPHTHYLETHYL)] N' [2 (ETHYL 4 ACETYLTHIAZOLYL)]THIOUREA; N [2 (2 INDOLYLETHYL)] N' [2 (THIAZOLYL)]THIOUREA; N [2 (3 INDOLYLETHYL)] N' [2 (4,6 DIMETHYLPYRIDYL)]THIOUREA; N [2 (3 INDOLYLETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [2 (3 INDOLYLETHYL)] N' [2 (5 CHLOROPYRIDYL)]THIOUREA; N [2 (3 INDOLYLETHYL)] N' [2 (6 METHYLPYRIDYL)]THIOUREA; N [2 (3 INDOLYLETHYL)] N' [2 (PYRIDYL)]THIOUREA; N [2 (4 BROMOPHENYLETHYL)] N' [2 (PYRIDYL)]THIOUREA; N [2 (4 HYDROXYPHENYLETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [2 (4 HYDROXYPHENYLETHYL)] N' [2 (5 CHLOROPYRIDYL)]THIOUREA; N [2 (4 HYDROXYPHENYLETHYL)] N' [2 (PYRIDYL)]THIOUREA; N [2 (4 HYDROXYPHENYLETHYL)] N' [2 (THIAZOLYL)]THIOUREA; N [2 (4 METHYLPHENYLETHYL)] N' [2 (4 METHYLTHIAZOLYL)]THIOUREA; N [2 (4 METHYLPHENYLETHYL)] N' [2 (ETHYL 4 ACETYLTHIAZOLYL)]THIOUREA; N [2 (4 METHYLPHENYLETHYL)] N' [2 (PYRIDYL)]THIOUREA; N [2 (4 METHYLPHENYLETHYL)] N' [2 (THIAZOLYL)]THIOUREA; N [2 (INDOLYLETHYL)] N' [2 (4 METHYLTHIAZOLYL)]THIOUREA; N [2 (INDOLYLETHYL)] N' [2 (5 METHYLPYRIDYL)]THIOUREA; N [2 (INDOLYLEYTHYL)] N' [2 (ETHYL 4 ACETYLTHIAZOLYL)]THIOUREA; NAPHTHYL GROUP; PHENETHYL ALCOHOL; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL SECRETION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; LIPOPHILICITY; MAST CELL; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RAT; RECEPTOR AFFINITY; SUBSTITUTION REACTION;

ANIMALS; ANTI-ALLERGIC AGENTS; CELLS, CULTURED; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HETEROCYCLIC COMPOUNDS; LEUKOTRIENE C4; LEUKOTRIENES; MAGNETIC RESONANCE SPECTROSCOPY; MAST CELLS; OPTICAL ROTATION; RATS; RECEPTORS, IGE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 0037334536     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00531-X     Document Type: Article

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