Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes

Journal of Neuroimmunology

Volumn 136, Issue 1-2, 2003, Pages 162-171

  Correale, Jorge ^a   Bassani Molinas, María De Los Milagros ^a  

^a Movement Disorders Section   (Argentina)

Author keywords

Autoimmunity; Clinically isolated syndromes; MBP; MOG; Multiple sclerosis

Indexed keywords

ANTIBODY; CD4 ANTIGEN; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 6; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; ONSET AGE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0037334286     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(03)00035-3     Document Type: Article

References (57)

1. q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement. J. Neuroimmunol. 111:2000;23-33.
2. Amor S., Groome N., Linington C., Morris M.M., Dornmair K., Gardinier M.V., Matthieu J.M., Baker D. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 153:1994;4349-4356.
3. Banki K., Colombo E., Sia F., Halladay D., Mattson D.H., Tatum A.H., Massa P.T., Phillips P.E., Perl A. Oligodendrocyte-specific expression and autoantigenicity of trasaldolase in multiple sclerosis. J. Exp. Med. 180:1994;1649-1663.
4. Bronstein J.M., Lallone R.L., Seitz R.S., Ellison G.W., Myers L.W. A humoral response to oligodendrocyte-specific protein in MS: a potential molecular mimic. Neurology. 53:1999;154-161.
5. Brunner C., Lassmann H., Waehneldt T.V., Matthieu J.M., Linington C. Differential ultrastructural localization of myelin basic protein, myelin/oligodendrocyte glycoprotein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J. Neurochem. 52:1989;296-304.
6. Correale J., McMillan M., McKarthy K., Le T., Weiner L.P. Isolation and characterization of autoreactive proteolipid protein-peptide specific T-cell clones from multiple sclerosis patients. Neurology. 45:1995;1370-1378.
7. Correale J., Lund B., McMillan M., Ko D., McCarthy K., Weiner L.P. T cell vaccination in secondary progressive multiple sclerosis. J. Neuroimmunol. 107:2000;130-139.
8. DeSilva D.R., Urdahl K.B., Jenkins M.K. Clonal anergy induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:1991;3261-3267.
9. Diaz-Villoslada P., Shih A., Shao L., Genain C., Hauser S.L. Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J. Neuroimmunol. 99:1999;36-43.
10. Elliot E.A., McFarland H.J., Nye S.H., Cofiell R., Wilson T.M., Wilkins J.A., Squinto S.P., Matis L.A., Mueller J.P. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. J. Clin. Invest. 98:1996;1602-1612.
11. Eylar E.H., Knisken P.J., Jackson J.J. Myelin basic proteins. Methods Enzymol. 32B:1979;323-341.
12. Genain C.P., Lee-Parritz D., Nguyen M.H., Massacesi L., Joshi N., Ferrante R., Hoffman K., Moseley M., Letvin N.L., Hauser S.L. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J. Clin. Invest. 94:1994;1339-1345.
13. Genain C.P., Nguyen M.H., Letvin N.L., Pearl R., Davis R.L., Adelman M., Lees M.B., Linington C., Hauser S.L. Antibody facilitation of multiple sclerosis-like lesions in a non human primate. J. Clin. Invest. 96:1995;2966-2974.
14. Genain C.P., Abel K., Belmar N., Villinger F., Rosenberg D.P., Linington C., Raine C.S., Hauser S.L. Late complications of immune deviation therapy in non human primates. Science. 274:1996;2054-2057.
15. Goebels N., Hofstetter H., Schmidt S., Brunner C., Wekerle H., Hohlfeld R. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects. Epitope spreading versus clonal persistence. Brain. 123:2000;508-518.
16. Hjelmström P., Juedes A.E., Fjell J., Ruddle N.H. B cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J. Immunol. 161:1998;4480-4483.
17. Hohlfeld R., Meinl E., Weber F., Zipp F., Schmidt S., Sotgiu S., Goebels N., Voltz R., Spuler S., Iglesias A., Wekerle H. The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis. Neurology. 45(Suppl. 6):1995;S33-S38.
18. Johns T., Kerlero de Rosbo N., Menon K.K., Abo S., Gonzalez M.F., Bernard C. Myelin oligodendrocyte glycoprotein induces demyelinating encephalomyelitis resembling multiple sclerosis. J. Immunol. 154:1995;5536-5541.
19. Kerlero de Rosbo N., Honegger P., Lassmann H., Matthieu J.M. Demyelination induced in aggregating brain cell cultures by a monoclonal antibody against myelin/oligodendrocyte glycoprotein. J. Neurochem. 55:1990;583-587.
20. Kerlero de Rosbo N., Milo R., Lees M.B., Burger D., Bernard C.C.A., Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92:1993;2602-2608.
21. Kerlero de Rosbo N., Mendel I., Ben-Nun A. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes. Eur. J. Immunol. 25:1995;985-993.
22. Kerlero de Rosbo N., Hoffman M., Mendel I., Yust I., Kaye J., Bakimer R., Flechter S., Abramsky O., Milo R., Karni A., Ben-Nun A. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 27:1997;3059-3069.
23. Kerlero de Rosbo N., Brok H.P.M., Bauer J., Kaye J.F., Hart B.A., Ben-Nun A. Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterization of immunodominant T- and B-cell epitopes. J. Neuroimmunol. 110:2000;83-96.
24. Kroemmer G., Martinez A.C. Mechanisms of self tolerance. Immunol. Today. 13:1992;401-404.
25. Kropefl J.F., Viise L.R., Charron A.J., Linington C., Gardiner M.V. Investigation of myelin/oligodendrocyte glycoprotein membrane topology. J. Neurochem. 67:1996;2219-2222.
26. Lindert R., Haase C.G., Brehm U., Linington C., Wekerle H., Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain. 122:1999;2089-2099.
27. Linington C., Lassmann H. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titer to the myelin/oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 17:1987;61-69.
28. Linington C., Bradl M., Lassmann H., Brunner C., Vass K. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against myelin oligodendrocyte glycoprotein. Am. J. Pathol. 130:1988;443-454.
29. Linington C., Berger T., Perry L., Weerth S., Hinze-Selch D., Zhang Y., Lu H.C., Lassman H., Wekerle H. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. Eur. J. Immunol. 23:1993;1364-1372.
30. Martin R., Jaraquemada D., Flerlage M., Richert J., Whitaker J., Long E.O., McFarlin D.E., McFarland H.F. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:1990;540-548.
31. Martin R., McFarlan H.F., McFarlin D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:1992;153-187.
32. McFarland H.I., Lobito A.A., Johnson M.M., Nyswaner J.T., Frank J.A., Palardy G.R., Tresser N., Genain C.P., Mueller J.P., Matis L.A., Lenardo M.J. Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J. Immunol. 162:1999;2384-2390.
33. Meinl E., Weber F., Drexler K., Morelle C., Ott M., Saruhan-Direskeneli G., Goebels N., Ertl B., Jechart G., Giegerich G., Schonbeck S., Bannwarth W., Wekerle H., Holfeld R. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. J. Clin. Invest. 92:1993;2633-2643.
34. b mice: fine specificity and T cell receptor Vβ expression of encephalitogenic T cells. Eur. J. Immunol. 25:1995;1951-1959.
35. Mor F., Cohen I.R. Pathogenicity of T cells responsive to diverse cryptic epitopes in myelin basic protein in Lewis rat. J. Immunol. 155:1995;3693-3699.
36. Morskophidis D., Lechner F., Pircher H., Zinkernagel R.M. Virus persistence in acutely infected immunocompetent mice, exhaustion of antiviral cytotoxic effector T cells. Nature. 362:1993;758-761.
37. O'Riordan J.L., Thompson A.J., Kingsley D.P., MacManus D.G., Kendall B.E., Rudge P., McDonald W.I., Miller D.H. The prognosis value of brain MRI in clinically isolated syndromes of the CNS: a 10-year follow up. Brain. 121:1998;495-503.
38. Pelfrey C.M., Tranquill L.R., Boehme S.A., McFarland H.F., Lenardo M.J. Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. J. Immunol. 154:1995;6191-6202.
39. Sailer M., O'Riordan J.L., Thompson A.J., Kingsley D.P., Macmanus D.G., McDonald W.I., Miller D.H. Quantitative MRI in patients with clinically isolated syndromes suggestive of demyelination. Neurology. 52:1999;599-606.
40. Salvetti M., Ristori G., D'Amato M., Buttinelli C., Falcone M., Fieschi C., Wekerle H., Pozilli C. Predominant and stable T-cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur. J. Immunol. 23:1993;1232-1239.
41. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:1996;299-302.
42. Stinissen P., Raus J., Zhang J. Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit. Rev. Immunol. 17:1997;33-75.
43. Sun J.B., Olsson T., Wang W.Z., Xiao B.G., Kostulas V., Fredrikson S., Ekre H.P., Link H. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21:1991;1461-1468.
44. Sun J., Link H., Olsson T., Xiao B.G., Andersson G., Ekre H.P., Linington C., Diener P. T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 146:1991;1490-1495.
45. Takacs K., Chandler P., Altmann D.M. Relapsing and remitting experimental allergic encephalomyelitis: a focused response to the encephalitogenic peptide rather than epitope spread. Eur. J. Immunol. 27:1997;2927-2934.
46. Tan L.J., Kennedy M.K., Dal Canto M.C., Miller S.D. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J. Immunol. 147:1991;1797-1802.
47. The 5-year risk of MS after optic neuritis: experience of the optic neuritis treatment trial. Neurology. 49:1997;1404-1413.
48. Tournier-Lasserve E., Hashim G.A., Bach M.A. Human T-cell response to myelin basic protein in multiple sclerosis patients and healthy subjects. J. Neurosci. Res. 19:1988;149-156.
49. Tuohy V.K., Yu M., Yin L., Kawczak J.A., Jonson J.M., Maticen P.M., Weinstock-Guttman B., Kinkel R.P. The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 164:1998;93-100.
50. Tuohy V.K., Yu M., Yin L., Kawczak J.A., Philip K.P. Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis. J. Exp. Med. 189:1999;1033-1042.
51. Vandenbark A.A., Chou Y.K., Bourdette D., Whitham R., Chilgren J., Chou C.H., Konat G., Hashim G., Vainiene M., Offner H. Human T lymphocyte response to myelin basic protein: selection of T lymphocyte lines from MBP-responsive donors. J. Neurosci. Res. 23:1989;21-30.
52. Vanderlugt C.L., Neville K.L., Nikcevich K.M., Eagar T.D., Bluestone J.A., Miller S.D. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. J. Immunol. 164:2000;670-678.
53. Weissert R., Wallstrom E., Storch M.K., Stefferl A., Lorentzen J., Lassmann H., Linington C., Olsson T. MHC-haplotype-dependent regulation of MOG-induced EAE in rats. J. Clin. Invest. 102:1998;1265-1273.
54. Wekerle H., Kojima K., Lannes-Vierra J., Lassmann H., Linington C. Animal models. Ann. Neurol. 36:1994;S47-S53.
55. Wucherpfenning K.W., Zhang J., Witek C., Marsui M., Modabber Y., Ota K., Hafler D.A. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:1994;5581-5592.
56. Xiao B.G., Linington C., Link H. Antibodies to myelin oligodendrocyte glycoprotein in cerebrospinal fluid from patients and controls. J. Neuroimmunol. 31:1991;91-96.
57. Zhang Y., Burger D., Saruhan G., Jeannet M., Steck A.J. The T lymphocyte response against myelin associated glycoprotein and myelin basic protein in patients with multiple sclerosis. Neurology. 43:1993;403-407.