Mechanisms of hepatic toxicity III. Intracellular signaling in response to toxic liver injury

American Journal of Physiology

Volumn 275, Issue 5 PART 1, 1998, Pages

  Jones, Brett E ^a   Czaja, Mark J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Activator protein 1; C myc; Ceramide; Fas; Mitogen activated protein kinase; Nitric oxide; Nuclear factor kb

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CERAMIDE; FAS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NITRIC OXIDE; PHOSPHOLIPASE C; SPHINGOLIPID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

CELL DEATH; CELL PROLIFERATION; GENE ACTIVATION; HUMAN; LIVER CELL; LIVER REGENERATION; LIVER TOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD95; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; FAS LIGAND PROTEIN; HUMANS; LIVER; MEMBRANE GLYCOPROTEINS; NITRIC OXIDE; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; TRANSCRIPTION FACTORS;

EID: 0031763135     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Arora, A. S., B. J. Jones, T. C. Patel, S. F. Bronk, and G. J. Gores. Ceramide induces hepatocyte cell death through disrup-tion of mitochondrial function in the rat. Hepatology 25: 958. 963,1997.
2. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-KB. Nature 376: 167-170, 1995.
3. Bellas, R. E., M. J. Fitzgerald, N. Fausto, and G. E. Sonnenshein. Inhibition of NF-KB activity induces apoptosis in murine hepatocytes. Am. J. Pathol. 151: 891-896,1997.
4. Bradham, C. A., R. F. Stachlewitz, W. Gao, T. Qian, S. Jayadev, G. Jenkins, Y. Hannun, J. J. Lemasters, R. G Thurman, and D. A. Brenner. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25:1128-1135,1997.
5. Chen, B. P. C., C. D. Wolfgang, and T. Hai. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd!53/ChoplO. Mol. Cell.Biol. 16:1157-1168,1996.
6. Chen, Q. I., and A. I. Cederbaum. Menadione cytotoxicity to Hep G2 cells and protection by activation of nuclear factor-KB. Mol. Pharmacol. 52:648-657,1997.
7. Diaz-Guerra, M. J. M., M. Velasco, P. Martin-Sanz, and L. Bosca. Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. J. Biol. Chem. 271:30114-30120,1996.
8. Diehl, A. M., S. S. Thorgeirsson, and C. J. Steer. Ethanol inhibits liver regeneration in rats without reducing transcripts of key photooncogenes. Gastroenterology 99:1105-1112,1990.
9. Diehl, A. M., S. Q. Yang, P. Cote, and G. S. Wand. Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. Hepatology 16:1212-1219,1992.
10. Galle, P. R., W. J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P. H. Krammer, and L. Runkel. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med. 182:1223-1230,1995.
11. Garcia-Ruiz, C., A. Colell, M. Mari, A. Morales, and J. C. Fernandez-Checa. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. J. Biol. Chem. 272:11369-11377,1997.
12. Gardner, C. R., D. E. Heck, C. S. Yang, P. E. Thomas, X.-J. Zhang, G. L. DeGeorge, J. D. Laskin, and D. L. Laskin. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 27:748-754,1998.
13. Goillot, E., J. Raingeaud, A. Ranger, R. I. Tepper, R. J. Davis, E. Harlow, and I. Sanchez. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc. Natl. Acad. Sei. USA 94:3302-3307,1997.
14. Hannun, Y. A. Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1859,1996.
15. Herbst, H., S. Milani, D. Schuppan, and H. Stein. Temporal and spatial patterns of proto-oncogene expression at early stages of toxic liver injury in the rat. Lab. Invest. 65:324-333,1991.
16. Higashi, K., and J. B. Hoek. Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes. J. Biol. Chem. 266:2178-2190,1991.
17. Hoek, J. B., A. P. Thomas, R. Rubin, and E. Rubin. Ethanolinduced mobilization of calcium by activation of phosphoinositidespecific phospholipase C in intact hepatocytes. J. Biol. Chem. 262: 682-691,1987.
18. Hug, H., S. Strand, A. Grambihler, J. Galle, V. Hack, W. Stremmel, P. H. Krammer, and P. R. Galle. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J. Biol. Chem. 272:28191-28193,1997.
19. limuro, Y., T. Nishiura, C. Hellerbrand, K. E. Behrns, R. Schoonhaven, J. W. Grisham, and D. A. Brenner. NF-KB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101:802-811,1998.
20. Kirn, Y.-M., M. E. de Vera, S. C. Watkins, and T. R. Billiar. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-a-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272:1402-1411,1997.
21. Kirn, Y.-M., R. V. Talanian, and T. R. Billiar. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272: 3113831148,1997.
22. Kroncke, K.-D., K. Fehsei, and V. Kolb-Bachofen. Nitric oxide: cytotoxicity versus cytoprotection-how, why, when, and where? Nitric Oxide 1:107-120,1997.
23. Lumpkin, C. K., Jr., J. M. Taylor, M. D. Tarpley, J. B. Hayden, T. M. Badger, and J. K. McClung. The effect of acute ethanol on growth in rat liver: steady state c-myc transcripts. Alcohol 9:279-282,1992.
24. Mendelson, K. G., L.-R. Contois, S. G. Tevosian, R. J. Davis, and K. E. Paulson. Independent regulation of JNK/p38 mitogenactivated protein kinases by metabolic oxidative stress in the liver. Proc. Natl. Acad. Sei. USA 93:12908-12913,1996.
25. Müller, M., S. Strand, H. Hug, E.-M. Heinemann, H. Walczak, W. J. Hofmann, W. Stremmel, P. H. Krammer, and P. R. Galle. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-I/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest. 99:403-413,1997.
26. Nathanson, M. H., and S. F. Schlosser. Calcium signaling mechanisms in liver in health and disease. Prog. Liver Dis. 14: 1-27,1996.
27. Nussler, A. K., and T. R. Billiar. Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukoc. Biol. 54: 171-178,1993.
28. Ogasawara, J., R. Watanabe-Fukunaga, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata. Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809,1993.
29. Ou, J., T. M. Carlos, S. C. Watkins, J. E. Saavedra, L. R. Keefer, Y.-M. Kirn, B. G. Harbrecht, and T. R. Billiar. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression and neutrophil accumulation during endotoxemia. Nitric Oxide 1:404-416,1997.
30. Park, S. K., H. L. Lin, and S. Murphy. Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-B binding to DNA. Biochem. J. 322: 609-613,1997.
31. Schmiedeberg, P., L. Biempica, and M. J. Czaja. Timing of protooncogene expression varies in toxin-induced liver regeneration. J. Cell. Physiol. 154:294-300,1993.
32. Strand, S., W. J. Hoftnann, A. Grambihler, H. Hug, M. Volkmann, G. Otto, H. Wesch, S. M. Mariani, V. Hack, W. Stremmel, P. H. Krammer, and P. R. Galle. Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat. Med. 4:588-593,1998.
33. Verma, I. M., J. K. Stevenson, E. M. Schwartz, D. Van Antwerp, and S. Miyamoto. Rel/NF-KB/lKB family: intimate tales of association and dissociation. Genes Dev. 9: 2723-2735, 1995.
34. Wang, C.-Y., M. W. Mayo, and A. S. Baldwin, Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-KB. Science 274: 784-787,1996.
35. Xu, Y., S. Bialik, B. E. Jones, Y. limuro, R. N. Kitsis, A. Srinivasan, D. A. Brenner, and M. J. Czaja. Inactivation of NF-KB converts a hepatocyte cell line TNF-a response from proliferation to apoptosis. Am. J. Physiol. 275 (Cell Physiol. 44): C1058-C1066,1998.
36. Xu, Y, C. Bradham, D. A. Brenner, and M. J. Czaja. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G795-G803,1997.
37. Xu, Y, Q. Nguyen, D. C. Lo, and M. J. Czaja. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. J. Cell. Physiol. 170:192-199,1997.
38. Xu, J., Y. Xu, Q. Nguyen, P. M. Novikoff, and M. J. Czaja. Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G60-G70,1996.
39. Zhang, B.-H., B. P. Horsfield, and G. C. Farrell. Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol triphosphate production: relevance to impaired liver regeneration. J. Clin. Invest. 98:1237-1244,1996.
40. Zeldin, G., S. Q. Yang, M. Yin, H. Z. Lin, R. Rai, and A. M. Diehl. Alcohol and cytokine-inducible transcription factors. Alcohol. Clin. Exp. Res. 20:1639-1645,1996.