Involvement of PI3′-K, mitogen-activated protein kinase and protein kinase B in the up-regulation of the expression of nNOSα and nNOSβ splicing variants induced by PRL-receptor activation in GH3 cells

Journal of Neurochemistry

Volumn 84, Issue 6, 2003, Pages 1367-1377

  Secondo, Agnese ^a   Sirabella, Rossana ^a   Formisano, Luigi ^a   D'Alessio, Angela ^a   Castaldo, Pasqualina ^a   Amoroso, Salvatore ^a   Ingleton, Patricia ^b   Di Renzo, Gianfranco ^a   Annunziato, Lucio ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

MAPK; Nitric oxide; NNOS; P13 K; PKB; Prolactin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTIBODY; CABERGOLINE; GENISTEIN; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROLACTIN RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; WORTMANNIN; AKT1 PROTEIN, RAT; ENZYME INHIBITOR; ERGOLINE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT; ONCOPROTEIN; PROLACTIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; EXON; GENE CONTROL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RNA SPLICING; SIGNAL TRANSDUCTION; UPREGULATION; ALTERNATIVE RNA SPLICING; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HYPOPHYSIS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALTERNATIVE SPLICING; ANIMALS; ANTIBODIES; CELL LINE; ENZYME INHIBITORS; ERGOLINES; EXONS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PHOSPHORYLATION; PITUITARY GLAND; PROLACTIN; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, PROLACTIN; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0037332455     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01626.x     Document Type: Article

References (39)

1. Alessi D. R. and Cohen P. (1998) Mechanism of activation and function of protein kinase B Curr. Opin. Genet. Dev. 8, 55-62
2. Annunziato L. (1979) Regulation of the tuberoinfundibular and nigro-striatal system. Evidence for different kinds of dopaminergic neurons in the brain. Neuroendocrinology 29, 66-76.
3. Baudhuin L. M., Cristina K. L., Lu J. and Xu Y. (2002) Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. Mol. Pharmacol. 62, 660-671.
4. Beckman J. S. and Koppenol W. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am. J. Physiol. 271, C1424-C1437.
5. Berlanga J. J., Gualillo O., Buteau H., Applanat M., Kelly P. A. and Edery M. (1997) Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase. J. Biol. Chem. 272, 2050-2052.
6. Bole-Feysot C., Goffin V., Edering V., Edering M., Binard N. and Kelly P. A. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr. Rev. 19, 225-268.
7. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
8. Bredt D. S. and Snyder S. H. (1990) Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc. Natl Acad. Sci. USA 87, 682-685.
9. Coffer P. J., Jin J. and Woodgett J. R. (1998) Protein kinase B (c-Akt): a multifunctional mediator of phossphatidylinositol 3-kinase activation. Biochem. J. 335, 1-13.
10. Colao A. M., Lombardi G. and Annunziato L. (2000) Cabergoline. Exp. Opin. Pharmacother 1, 555-574.
11. Corbacho A. M., Nava G., Eiserich J., Noris G., Macotela Y., Struman I., Martinez de la Escalera G., Freeman B. A. and Clapp C. (2000) Proteolytic cleavage confers nitric oxide synthase inducing activity upon prolactin. J. Biol. Chem. 275, 13183-13186.
12. Duvilanski B. H., Zambruno C., Seilicovich A., Pisera A., Lasaga M., del Diaz M. C., Belova N., Rettori V. and McCann S. M. (1995) Role of nitric oxide in control of prolactin release by the adenohypophysis. Proc. Natl Acad. Sci. USA 92, 170-174.
13. Duvilanski B. H., Zambruno C., Lasaga M., Pisera D. and Seilicovich A. (1996) Role of nitric oxide/cyclic GMP pathway in the inhibitory effect of GABA on prolactin release. J. Neuroendocrinol. 8, 909-913.
14. Eliasson M., Blackshaw S., Schell M. and Snyder S. H. (1997) Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. Proc. Natl Acad. Sci. USA 94, 3396-3401.
15. Freeman M., Kanyicska B., Lerant A. and Nagy G. (2000) Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80, 1523-1631.
16. Garthwaite J. and Boulton C. L. (1995) Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57, 683-706.
17. Gonzalez D. and Aguilar E. (1999) In vitro, nitric oxide (NO) stimulates LH secretion and partially prevents the inhibitory effect of dopamine on PRL release. J. Endocrinol. Invest. 22, 772-780.
18. Green L. C., Wagner D. A., Glogowski J., Skipper P. L., Wishnok J. S. and Tannenbaum S. R. (1982) Analysis of nitrate, nitrite and [15N]nitrate in biological fluids. Anal. Biochem. 126, 131-138.
19. Ignarro L. J. (1996) Physiology and pathophysiology of nitric oxide. Kidney Int. Supplement 55, S2-S5.
20. Ji S., Frank S. J. and Messina J. L. (2002) Growth hormone-induced differential desensitisation of STAT5, ERK, and Akt phosphorylation. J. Biol. Chem. 277, 28384-28393.
21. 3 cells. Endocrinology 131, 595-601.
22. Krown K., Wang Y. F. and Walker A. M. (1994) Autocrine interaction between prolactin and its receptor occurs intracellularly in the 2351 mammotroph cell line. Endocrinology 134, 1546-1552.
23. Lloyd R. V., Jin L., Quian X., Zhang S. and Scheithauer B. W. (1995) Nitric oxide synthase in the human pituitary gland. Am. J. Pathol. 146, 86-94.
24. Marte B. M. and Downward J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22, 355-358.
25. Mattace Raso G., Meli R., Gualillo O., Pacilio M. and Di Carlo R. (1999) Prolactin induction of nitric oxide synthase in rat C6 glioma cells. J. Neurochem. 73, 2272-2277.
26. Meli R., Mattace Raso G., Gualillo O., Pacilio M. and Di Carlo R. (1997) Prolactin modulation of nitric oxide and TNF-a production by peripheral neutrophils in rats. Life Sci. 61, 1395-1403.
27. Melmed S., Carlson H. E., Briggs J. and Hershman J. M. (1980) Autofeedback of prolactin-secreting pituitary cells. Hormone Res. 12, 340-344.
28. Moncada S., Higgs A. and Furchgott R. (1997) International union of pharmacology nomenclature in nitric oxide research. Pharmacol. Rev. 49, 137-142.
29. Nevelainen M. T, Valve E. M., Ingleton P. M. and Harkonen P. L. (1996) Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate. Endocrinology 137, 3078-3088.
30. Ohta K., Hirata Y. and Marumo F. (1993) Interleukin-1 β induces nitric oxide production by a mouse pituitary tumour cell line (AtT20/D16). J. Endocrinol. 138, 429-435.
31. Polkowski K. and Mazurek A. P. (2000) Biological properties of genistein. A review of in vitro and in vivo data. Acta Pol. Pharm. 57, 135-155.
32. Quian X., Jin L. and Lloyd R. V. (1998) Percoll density gradient-enriched populations of rat pituitary cells: interleukin 6 secretion, proliferative activity, and nitric oxide synthase expression. Endocr. Pathol. 9, 339-346.
33. Rains C. P., Bryson H. M. and Fitton A. (1995) Cabergoline. Drugs 49, 255-279.
34. Salazar E. P. and Rozengurt E. (2001) Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397. J. Biol. Chem. 276, 17788-17795.
35. Thompsen L. L., Lawton F. G., Knowles R. G., Beesley J. E., Rivers-Moreno V. and Moncada S. (1994) Nitric oxide synthase activity in human gynecological cancer. Cancer Res. 54, 1352-1354.
36. Tortonese D. J., Brooks J., Ingleton P. and McNeilly A. S. (1998) Detection of prolactin receptor gene expression in the sheep pituitary gland and visualization of the specific translation of the signal in gonadotrophs. Endocrinology 139, 5215-5223.
37. Traxler P., Bold G., Frei J., Lang M., Lydon N., Mett H., Buchdunger E., Meyer T, Mueller M. and Furet P. (1997) Use of a pharmacophore model for the design of EGF-R. tyrosine kinase inhibitors: 4-(phenylamino) pyrazolo[3,4-d]pyrimidines. J. Med. Chem. 40, 3601-3616.
38. Velardez M. O., De Laurentiis A., del Carmen Diaz M., Lasaga M., Pisera D., Seilicovich A. and Duvilanski H. (2000) Role of phosphodiesterase and protein kinase G on nitric oxide-induced inhibition of prolactin release from the rat anterior pituitary. European J. Endocrinol. 143, 279-284.
39. 3 pituitary cells. Biochem. J. 285, 201-206.