Orchestrating sleep-wake functions in the brain

Nature Medicine

Volumn 9, Issue 2, 2003, Pages 170-171

  Hajak, Göran ^a   Geisler, Peter ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; OREXIN;

AROUSAL; BRAIN FUNCTION; FEEDBACK SYSTEM; HYPOTHALAMUS; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SLEEP WAKING CYCLE;

ANIMALS; BRAIN; CARRIER PROTEINS; GLUTAMIC ACID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; NEUROPEPTIDES; SLEEP; WAKEFULNESS;

EID: 0037329338     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0203-170     Document Type: Short Survey

References (12)

1. von Economo, C. et al. in Der Schlaf (ed. Sarason, D.) 38-54 (Lehmann, München, Germany, 1929).
2. von Economo, C. Sleep as a problem of localization. J. Nerv. Ment. Dis. 71, 249-259 (1930).
3. Li, Y., Gao, X.-B., Sakurai, T. & van den Pol, A.N. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - a potential mechanism for orchestrating the hypothalamus arousal system. Neuron 36, 1169-1181 (2002).
4. Mignot, E., Taheri, S. & Nishino, S. Sleeping with the hypothalamus: emerging therapeutic target for sleep disorders. Nat. Neurosci. 5 (suppl.), 1071-1075 (2002).
5. Sutcliffe, J.G. & de Lecea, L. The hypocretins: setting the arousal threshold. Nat. Rev. Neurosci. 3, 339-349 (2002).
6. Mieda, M. & Yanagisawa, M. Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors. Curr. Opin. Neurobiol. 12, 339-345 (2002).
7. de Lecea, L., Sutcliffe, J.G. & Farbre, V. Hypocretin/orexins as integrators of physiological information. Neuropeptides 36, 85-95 (2002).
8. Shirasaka, T., Kunitake, T., Takasaki, M. & Kannan, H. Neuronal effects of orexins: relevant to sympathetic and cardiovascular effects. Regul. Peptides 104, 91-95 (2002).
9. Overeem, S., Mignot, E., van Diijk, J.G. & Lammers, G.J. Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J. Clin. Neurophysiol. 18, 78-105 (2001).
10. Taheri, S., Zeitzer, J.M. & Mignot, E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25, 283-313 (2002).
11. Overeem, S., Scammell, T.E. & Lammers, G.J. Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Curr. Opin. Neuro. 16, 739-745 (2002).
12. Draganski, B. et al. Hypothalamic grey matter changes in narcoleptic patients. Nature Med. 8, 1186-1188 (2002).