Hypothalamic gray matter changes in narcoleptic patients [2]

Nature Medicine

Volumn 8, Issue 11, 2002, Pages 1186-1188

  Draganski, B ^a   Geisler, P ^a   Hajak, G ^a   Schuierer, G ^a   Bogdahn, U ^a   Winkler, J ^a   May, A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN; OREXIN A; OREXIN B;

ADULT; ANTERIOR HYPOTHALAMUS; CATAPLEXY; CEREBELLUM VERMIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DORSAL RAPHE NUCLEUS; FEMALE; GRAY MATTER; HUMAN; HYPNAGOGIC HALLUCINATION; HYPOTHALAMUS; LETTER; LOCUS CERULEUS; MALE; NARCOLEPSY; NIGHT SLEEP; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; PARASOMNIA; PRIORITY JOURNAL; REM SLEEP; SLEEP WAKING CYCLE; SOMNOLENCE;

ADULT; FEMALE; HUMANS; HYPOTHALAMUS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NARCOLEPSY;

EID: 18744406284     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1102-1186     Document Type: Letter

References (13)

1. Peyron, C. et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nature Med. 6, 991-997 (2000).
2. Thannickal, T.C. et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469-474 (2000).
3. Mignot, E. & Thorsby, E. Narcolepsy and the HLA system. N. Engl. J. Med. 344, 692 (2001).
4. Ashburner, J. & Friston, K.J. Voxel-based morphometry - The methods. Neuroimage 11, 805-821 (2000).
5. May, A. et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Med. 5, 836-838 (1999).
6. Good, C.D. et al. Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14, 685-700 (2001).
7. Wright, I.C. et al. A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia. Neuroimage 2, 244-252 (1995).
8. Mummery, C.J. et al. A voxel-based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory. Ann. Neurol. 47, 36-45 (2000).
9. Overeem, S. et al. Voxel based morphometry in hypocretin-deficient narcolepsy. Sleep 25, 102 (2002).
10. Khan, N. et al. Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-raclopride. Neurology 44, 2102-2104 (1994).
11. Kanbayashi, T., Honda, K., Kodama, T., Mignot, E. & Nishino, S. Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: A study of D- and L-derivatives in canine narcolepsy. Neuroscience 99, 651-659 (2000).
12. Peyron, C. et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18, 9996-10015 (1998).
13. Ikemoto, S. & Panksepp, J. The role of nucleus accumbens dopamine in motivated behavior: A unifying interpretation with special reference to reward-seeking. Brain Res. Brain Res. Rev. 31, 6-41 (1999).