Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein

Nucleic Acids Research

Volumn 31, Issue 3, 2003, Pages 963-973

  Christiansen, Mette ^b   Stevnsner, Tinna ^b   Modin, Charlotte ^a   Martensen, Pia M ^b   Brosh Jr , Robert M ^c   Bohr, Vilhelm A ^c  

^a AARHUS UNIVERSITY   (Denmark)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c Danish Ctr for Molec Gerontology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; MUTANT PROTEIN; PROTEIN CSA; PROTEIN CSB; UNCLASSIFIED DRUG;

BACULOVIRUS; COCKAYNE SYNDROME; CONTROLLED STUDY; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; BASE SEQUENCE; CELLS, CULTURED; CONSERVED SEQUENCE; DNA; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA REPAIR ENZYMES; HUMANS; MUTATION; NUCLEIC ACID CONFORMATION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

UNIDENTIFIED BACULOVIRUS;

EID: 0037324344     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg164     Document Type: Review

References (48)

1. Venema,J., Mullenders,L.H., Natarajan,A.T., van Zeeland,A.A. and Mayne,L.V. (1990) The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc. Natl Acad. Sci. USA, 87, 4707-4711.
2. Nance,M.A. (2000) GeneReviews at GeneTests-GeneClinics: Medical Genetics Information Resource (database online). Copyright, University of Washington, Seattle, 1997-2001. Available at http://www.geneclinics.org or http://www.genetests.org, Vol. 2002.
3. Troelstra,C., van Gool,A., de Wit,J., Vermeulen,W., Bootsma,D. and Hoeijmakers,J.H. (1992) ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes. Cell, 71, 939-953.
4. Eisen,J.A., Sweder,K.S. and Hanawalt,P.C. (1995) Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res., 23, 2715-2723.
5. Pazin,M.J. and Kadonaga,J.T. (1997) SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Cell, 88, 737-740.
6. Selby,C.P. and Sancar,A. (1997) Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II. J. Biol. Chem., 272, 1885-1890.
7. Tantin,D., Kansal,A. and Carey,M. (1997) Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes. Mol. Cell. Biol., 17, 6803-6814.
8. Citterio,E., Rademakers,S., van der Horst,G.T., van Gool,A.J., Hoeijmakers,J.H. and Vermeulen,W. (1998) Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein. J. Biol. Chem., 273, 11844-11851.
9. Citterio,E., Van Den Boom,V., Schnitzler,G., Kanaar,R., Bonte,E., Kingston,R.E., Hoeijmakers,J.H. and Vermeulen,W. (2000) ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor. Mol. Cell. Biol., 20, 7643-7653.
10. Hall,M.C. and Matson,S.W. (1999) Helicase motifs: the engine that powers DNA unwinding. Mol. Microbiol., 34, 867-877.
11. Velankar,S.S., Soultanas,P., Dillingham,M.S., Subramanya,H.S. and Wigley,D.B. (1999) Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Cell, 97, 75-84.
12. Kim,J.L., Morgenstern,K.A., Griffith,J.P., Dwyer,M.D., Thomson,J.A., Murcko,M.A., Lin,C. and Caron,P.R. (1998) Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure, 6, 89-100.
13. Selzer,R.R., Nyaga,S., Tuo,J., May,A., Muftuoglu,M., Christiansen,M., Citterio,E., Brosh,R.M.,Jr and Bohr,V.A. (2002) Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res., 30, 782-793.
14. Muftuoglu,M., Selzer,R., Tuo,J., Brosh,R.M.,Jr and Bohr,V.A. (2002) Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene, 283, 27-40.
15. Brosh,R.M.,Jr, Balajee,A.S., Selzer,R.R., Sunesen,M., Proietti De Santis,L. and Bohr,V.A. (1999) The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair. Mol. Biol. Cell, 10, 3583-3594.
16. Sunesen,M., Selzer,R.R., Brosh,R.M.,Jr, Balajee,A.S., Stevnsner,T. and Bohr,V.A. (2000) Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein. Nucleic Acids Res., 28, 3151-3159.
17. Dianov,G., Bischoff,C., Sunesen,M. and Bohr,V.A. (1999) Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res., 27, 1365-1368.
18. Stevnsner,T., Nyaga,S., de Souza-Pinto,N.C., van der Horst,G.T.J., Gorgels,T.G.M.F., Hogue,B.A., Thorslund,T. and Bohr,V.A. (2002) Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene, 21, 8675-8682.
19. Tuo,J., Jaruga,P., Rodriguez,H., Dizdaroglu,M. and Bohr,V.A. (2002) The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. J. Biol. Chem., 277, 30832-30837.
20. Tuo,J., Muftuoglu,M., Chen,C., Jaruga,P., Selzer,R.R., Brosh,R.M.,Jr, Rodriguez,H., Dizdaroglu,M. and Bohr,V.A. (2001) The Cockayne syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA. J. Biol. Chem., 276, 45772-45779.
21. Tuo,J., Chen,C., Zeng,X., Christiansen,M. and Bohr,V.A. (2002) Functional crosstalk between hOGG1 and the helicase domain of Cockayne syndrome group B protein. DNA Repair, 1, 913-927.
22. Selby,C.P. and Sancar,A. (1997) Cockayne syndrome group B protein enhances elongation by RNA polymerase II. Proc. Natl Acad. Sci. USA, 94, 11205-11209.
23. Svejstrup,J.Q., Vichi,P. and Egly,J.M. (1996) The multiple roles of transcription/repair factor TFIIH. Trends Biochem. Sci., 21, 346-350.
24. Tijsterman,M., Tasseron-de Jong,J.G., Verhage,R.A. and Brouwer,J. (1998) Defective Kin28, a subunit of yeast TFIIH, impairs transcription-coupled but not global genome nucleotide excision repair. Mutat. Res., 409, 181-188.
25. Araujo,S.J., Tirode,F., Coin,F., Pospiech,H., Syvaoja,J.E., Stucki,M., Hubscher,U., Egly,J.M. and Wood,R.D. (2000) Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH and modulation by CAK. Genes Dev., 14, 349-359.
26. Muchardt,C., Reyes,J.C., Bourachot,B., Leguoy,E. and Yaniv,M. (1996) The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J., 15, 3394-3402.
27. Berube,N.G., Smeenk,C.A. and Picketts,D.J. (2000) Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association. Hum. Mol. Genet., 9, 539-547.
28. Bartek,J. and Lukas,J. (2001) Pathways governing G1/S transition and their response to DNA damage. FEBS Lett., 490, 117-122.
29. Yu,A., Fan,H.Y., Liao,D., Bailey,A.D. and Weiner,A.M. (2000) Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2 and 5S genes. Mol. Cell, 5, 801-810.
30. Athas,W.F., Hedayati,M.A., Matanoski,G.M., Farmer,E.R. and Grossman,L. (1991) Development and field-test validation of an assay for DNA repair in circulating human lymphocytes. Cancer Res., 51, 5786-5793.
31. Anson,R.M., Croteau,D.L., Stierum,R.H., Filburn,C., Parsell,R. and Bohr,V.A. (1998) Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucleic Acids Res., 26, 662-668.
32. Batty,D., Rapic'-Otrin,V., Levine,A.S. and Wood,R.D. (2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J. Mol. Biol., 300, 275-290.
33. Encell,L., Shuker,D.E., Foiles,P.G. and Gold,B. (1996) The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester. Chem Res. Toxicol., 9, 563-567.
34. Brosh,R.M.,Jr and Matson,S.W. (1996) A partially functional DNA helicase II mutant defective in forming stable binary complexes with ATP and DNA. A role for helicase motif III. J. Biol. Chem., 271, 25360-25368.
35. Mielke,C., Tummler,M., Schubeler,D., von Hoegen,I. and Hauser,H. (2000) Stabilized, long-term expression of heterodimeric proteins from tricistronic mRNA. Gene, 254, 1-8.
36. Wakasugi,M. and Sancar,A. (1998) Assembly, subunit composition and footprint of human DNA repair excision nuclease. Proc. Natl Acad. Sci. USA, 95, 6669-6674.
37. Fiedler,U. and Timmers,H.T. (2001) Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation. Nucleic Acids Res., 29, 2706-2714.
38. Pause,A., Methot,N., Svitkin,Y., Merrick,W.C. and Sonenberg,N. (1994) Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J., 13, 1205-1215.
39. Fernandez,A., Guo,H.S., Saenz,P., Simon-Buela,L., Gomez de Cedron,M. and Garcia,J.A. (1997) The motif V of plum pox potyvirus CI RNA helicase is involved in NTP hydrolysis and is essential for virus RNA replication. Nucleic Acids Res., 25, 4474-4480.
40. Kim,D.W., Kim,J., Gwack,Y., Han,J.H. and Choe,J. (1997) Mutational analysis of the hepatitis C virus RNA helicase. J. Virol., 71, 9400-9409.
41. Gelasco,A. and Lippard,S.J. (1998) NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry, 37, 9230-9239.
42. Kim,J.K., Patel,D. and Choi,B.S. (1995) Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: implication in mutagenesis and repair activity. Photochem. Photobiol., 62, 44-50.
43. Boiteux,S., Gajewski,E., Laval,J. and Dizdaroglu,M. (1992) Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry, 31, 106-110.
44. Teitz,T., Eli,D., Penner,M., Bakhanashvili,M., Naiman,T., Timme,T.L., Wood,C.M., Moses,R.E. and Canaani,D. (1990) Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. Mutat. Res., 236, 85-97.
45. Toczyski,D.P., Galgoczy,D.J. and Hartwell,L.H. (1997) CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell, 90, 1097-1106.
46. Ariza,R.R., Keyse,S.M., Moggs,J.G. and Wood,R.D. (1996) Reversible protein phosphorylation modulates nucleotide excision repair of damaged DNA by human cell extracts. Nucleic Acids Res., 24, 433-440.
47. Sif,S., Stukenberg,P.T., Kirschner,M.W. and Kingston,R.E. (1998) Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev., 12, 2842-2851.
48. Rockx,D.A., Mason,R., van Hoffen,A., Barton,M.C., Citterio,E., Bregman,D.B., van Zeeland,A.A., Vrieling,H. and Mullenders,L.H. (2000) UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II. Proc. Natl Acad. Sci. USA, 97, 10503-10508.