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Volumn 84, Issue 2-3, 2003, Pages 171-180

Overexpressed glucocorticoid receptor negatively regulates gene expression under conditions that favour accumulation of non-hormone-binding forms of the receptor

Author keywords

Glucocorticoid receptor; Overexpression; Transcriptional repression

Indexed keywords

CELL EXTRACT; CELL NUCLEUS RECEPTOR; DEXAMETHASONE; DNA BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MESYLIC ACID; PROTEIN; TRANSCRIPTION FACTOR; TRITIUM;

EID: 0037322219     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00027-X     Document Type: Conference Paper
Times cited : (21)

References (40)
  • 1
    • 0023649571 scopus 로고
    • Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor
    • Hollenberg S.M., Giguere V., Segui P., Evans R.M. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell. 49(1):1987;39-46.
    • (1987) Cell , vol.49 , Issue.1 , pp. 39-46
    • Hollenberg, S.M.1    Giguere, V.2    Segui, P.3    Evans, R.M.4
  • 2
    • 0023340611 scopus 로고
    • Functional dissection of the hormone and DNA-binding activities of the glucocorticoid receptor
    • Rusconi S., Yamamoto K.R. Functional dissection of the hormone and DNA-binding activities of the glucocorticoid receptor. EMBO J. 6(5):1987;1309-1315.
    • (1987) EMBO J. , vol.6 , Issue.5 , pp. 1309-1315
    • Rusconi, S.1    Yamamoto, K.R.2
  • 3
    • 0023235562 scopus 로고
    • Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation
    • Miesfeld R., Godowski P.J., Maler B.A., Yamamoto K.R. Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science. 236(4800):1987;423-427.
    • (1987) Science , vol.236 , Issue.4800 , pp. 423-427
    • Miesfeld, R.1    Godowski, P.J.2    Maler, B.A.3    Yamamoto, K.R.4
  • 4
    • 0026756271 scopus 로고
    • Determinants of high-affinity DNA binding by the glucocorticoid receptor: Evaluation of receptor domains outside the DNA-binding domain
    • Dahlman-Wright K., Wright A.P., Gustafsson J.-A. Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain. Biochemistry. 31(37):1992;9040-9044.
    • (1992) Biochemistry , vol.31 , Issue.37 , pp. 9040-9044
    • Dahlman-Wright, K.1    Wright, A.P.2    Gustafsson, J.-A.3
  • 5
    • 0026713869 scopus 로고
    • Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors
    • Ylikomi T., Bocquel M.T., Berry M., Gronemeyer H., Chambon P. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J. 11(10):1992;3681-3694.
    • (1992) EMBO J. , vol.11 , Issue.10 , pp. 3681-3694
    • Ylikomi, T.1    Bocquel, M.T.2    Berry, M.3    Gronemeyer, H.4    Chambon, P.5
  • 6
    • 0027256152 scopus 로고
    • Evidence that the hormone-binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat shock protein 90
    • Scherrer L.C., Picard D., Massa E., Harmon J.M., Simons S.S. Jr., Yamamoto K.R., Pratt W.B. Evidence that the hormone-binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat shock protein 90. Biochemistry. 32(20):1993;5381-5386.
    • (1993) Biochemistry , vol.32 , Issue.20 , pp. 5381-5386
    • Scherrer, L.C.1    Picard, D.2    Massa, E.3    Harmon, J.M.4    Simons S.S., Jr.5    Yamamoto, K.R.6    Pratt, W.B.7
  • 7
    • 0032571320 scopus 로고    scopus 로고
    • The role of DnaJ-like proteins in glucocorticoid receptor-hsp90 heterocomplex assembly by the reconstituted hsp90-p60-hsp70 foldosome complex
    • Dittmar K.D., Banach M., Galigniana M.D., Pratt W.B. The role of DnaJ-like proteins in glucocorticoid receptor-hsp90 heterocomplex assembly by the reconstituted hsp90-p60-hsp70 foldosome complex. J. Biol. Chem. 273(13):1998;7358-7366.
    • (1998) J. Biol. Chem. , vol.273 , Issue.13 , pp. 7358-7366
    • Dittmar, K.D.1    Banach, M.2    Galigniana, M.D.3    Pratt, W.B.4
  • 8
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt W.B., Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18(3):1997;306-360.
    • (1997) Endocr. Rev. , vol.18 , Issue.3 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 9
    • 0026343608 scopus 로고
    • Protein components of the non-activated glucocorticoid receptor
    • Rexin M., Busch W., Gehring U. Protein components of the non-activated glucocorticoid receptor. J. Biol. Chem. 266(36):1991;24601-24605.
    • (1991) J. Biol. Chem. , vol.266 , Issue.36 , pp. 24601-24605
    • Rexin, M.1    Busch, W.2    Gehring, U.3
  • 10
    • 0026511544 scopus 로고
    • Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell
    • Alexis M.N., Mavridou I., Mitsiou D.J. Subunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell. Eur. J. Biochem. 204(1):1992;75-84.
    • (1992) Eur. J. Biochem. , vol.204 , Issue.1 , pp. 75-84
    • Alexis, M.N.1    Mavridou, I.2    Mitsiou, D.J.3
  • 11
    • 0032484127 scopus 로고    scopus 로고
    • The assembly of progesterone receptor-hsp90 complexes using purified proteins
    • Kosano H., Stensgard B., Charlesworth M.C., McMahon N., Toft D. The assembly of progesterone receptor-hsp90 complexes using purified proteins. J. Biol. Chem. 273(49):1998;32973-32979.
    • (1998) J. Biol. Chem. , vol.273 , Issue.49 , pp. 32973-32979
    • Kosano, H.1    Stensgard, B.2    Charlesworth, M.C.3    McMahon, N.4    Toft, D.5
  • 13
    • 0034463399 scopus 로고    scopus 로고
    • Molecular chaperone interactions with steroid receptors: An update
    • Cheung J., Smith D.F. Molecular chaperone interactions with steroid receptors: an update. Mol. Endocrinol. 14(7):2000;939-946.
    • (2000) Mol. Endocrinol. , vol.14 , Issue.7 , pp. 939-946
    • Cheung, J.1    Smith, D.F.2
  • 14
    • 0023896114 scopus 로고
    • Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state
    • Denis M., Poellinger L., Wikstöm A.-C., Gustafsson J.-A. Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state. Nature. 333(6174):1988;686-688.
    • (1988) Nature , vol.333 , Issue.6174 , pp. 686-688
    • Denis, M.1    Poellinger, L.2    Wikstöm, A.-C.3    Gustafsson, J.-A.4
  • 16
    • 0036515648 scopus 로고    scopus 로고
    • Nuclear receptor co-regulators: Multiple modes of modification
    • Hermanson O., Glass C.K., Rosenfeld M.G. Nuclear receptor co-regulators: multiple modes of modification. Trends Endocrinol. Metab. 13(2):2002;55-60.
    • (2002) Trends Endocrinol. Metab. , vol.13 , Issue.2 , pp. 55-60
    • Hermanson, O.1    Glass, C.K.2    Rosenfeld, M.G.3
  • 17
    • 0032052279 scopus 로고    scopus 로고
    • Molecular chaperones and subcellular trafficking of steroid receptors
    • DeFranco D.B., Ramakrishnan C., Tang Y. Molecular chaperones and subcellular trafficking of steroid receptors. J. Steroid Biochem. Mol. Biol. 65(1-6):1998;51-58.
    • (1998) J. Steroid Biochem. Mol. Biol. , vol.65 , Issue.1-6 , pp. 51-58
    • DeFranco, D.B.1    Ramakrishnan, C.2    Tang, Y.3
  • 18
    • 0031447219 scopus 로고    scopus 로고
    • Overexpression of unliganded steroid receptors activates endogenous heat shock factor
    • Xiao N., DeFranco D.B. Overexpression of unliganded steroid receptors activates endogenous heat shock factor. Mol. Endocrinol. 11(9):1997;1365-1374.
    • (1997) Mol. Endocrinol. , vol.11 , Issue.9 , pp. 1365-1374
    • Xiao, N.1    DeFranco, D.B.2
  • 19
    • 0026750001 scopus 로고
    • Heat shock gene regulation by nascent polypeptides and denatured proteins: Hsp70 as a potential autoregulatory factor
    • Baler R., Welch W.J., Voellmy R. Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J. Cell Biol. 117(6):1992;1151-1159.
    • (1992) J. Cell Biol. , vol.117 , Issue.6 , pp. 1151-1159
    • Baler, R.1    Welch, W.J.2    Voellmy, R.3
  • 20
    • 0027957428 scopus 로고
    • Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor-glucocorticoid response element complex
    • Srinivasan G., Patel N.T., Thompson E.B. Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor-glucocorticoid response element complex. Mol. Endocrinol. 8(2):1994;189-196.
    • (1994) Mol. Endocrinol. , vol.8 , Issue.2 , pp. 189-196
    • Srinivasan, G.1    Patel, N.T.2    Thompson, E.B.3
  • 21
    • 0025221344 scopus 로고
    • Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90
    • Sanchez E.R., Hirst M., Scherrer L.C., Tang H.-Y., Welsh M.J., Harmon J.M., Simons S.S. Jr., Ringold G.M., Pratt W.B. Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90. J. Biol. Chem. 265(33):1990;20123-20130.
    • (1990) J. Biol. Chem. , vol.265 , Issue.33 , pp. 20123-20130
    • Sanchez, E.R.1    Hirst, M.2    Scherrer, L.C.3    Tang, H.-Y.4    Welsh, M.J.5    Harmon, J.M.6    Simons S.S., Jr.7    Ringold, G.M.8    Pratt, W.B.9
  • 22
    • 0026028847 scopus 로고
    • Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a non-random manner throughout all planes of the nucleus
    • Martins V.R., Pratt W.B., Terracio L., Hirst M.A., Ringold G.M., Housley P.R. Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a non-random manner throughout all planes of the nucleus. Mol. Endocrinol. 5(2):1991;217-225.
    • (1991) Mol. Endocrinol. , vol.5 , Issue.2 , pp. 217-225
    • Martins, V.R.1    Pratt, W.B.2    Terracio, L.3    Hirst, M.A.4    Ringold, G.M.5    Housley, P.R.6
  • 23
    • 0242490975 scopus 로고
    • Synergistic action of the glucocorticoid receptor with transcription factors
    • Strahle U., Schmid W., Schütz G. Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J. 7(11):1988;3389-3395.
    • (1988) EMBO J. , vol.7 , Issue.11 , pp. 3389-3395
    • Strahle, U.1    Schmid, W.2    Schütz, G.3
  • 25
    • 0024548919 scopus 로고
    • Two human 90 kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II
    • Lees-Miller S.P., Anderson C.W. Two human 90 kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II. J. Biol. Chem. 264(5):1989;2431-2437.
    • (1989) J. Biol. Chem. , vol.264 , Issue.5 , pp. 2431-2437
    • Lees-Miller, S.P.1    Anderson, C.W.2
  • 26
    • 0028946964 scopus 로고
    • Temporary loss of glucocorticoid receptor-mediated regulation of gene expression in heat shocked cells
    • Mitsiou D.J., Alexis M.N. Temporary loss of glucocorticoid receptor-mediated regulation of gene expression in heat shocked cells. FEBS Lett. 362(3):1995;309-315.
    • (1995) FEBS Lett. , vol.362 , Issue.3 , pp. 309-315
    • Mitsiou, D.J.1    Alexis, M.N.2
  • 27
    • 0027285466 scopus 로고
    • Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor
    • Stancato L.F., Hutchison K.A., Chakraborti P.K., Simons S.S. Jr., Pratt W.B. Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor. Biochemistry. 32(14):1993;3729-3736.
    • (1993) Biochemistry , vol.32 , Issue.14 , pp. 3729-3736
    • Stancato, L.F.1    Hutchison, K.A.2    Chakraborti, P.K.3    Simons S.S., Jr.4    Pratt, W.B.5
  • 29
    • 0026687628 scopus 로고
    • Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors
    • Chakraborti P.K., Garabedian M.J., Yamamoto K.R., Simons S.S. Jr. Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors. J. Biol. Chem. 267(16):1992;11366-11373.
    • (1992) J. Biol. Chem. , vol.267 , Issue.16 , pp. 11366-11373
    • Chakraborti, P.K.1    Garabedian, M.J.2    Yamamoto, K.R.3    Simons S.S., Jr.4
  • 31
    • 0021962337 scopus 로고
    • Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin
    • Grippo J.F., Holmgren A., Pratt W.B. Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin. J. Biol. Chem. 260(1):1985;93-97.
    • (1985) J. Biol. Chem. , vol.260 , Issue.1 , pp. 93-97
    • Grippo, J.F.1    Holmgren, A.2    Pratt, W.B.3
  • 33
    • 0032555685 scopus 로고    scopus 로고
    • Repression of heat shock transcription factor HSF1 activation by hsp90 (hsp90 complex) that forms a stress-sensitive complex with HSF1
    • Zou J., Guo Y., Guettouche T., Smith D.F., Voellmy R. Repression of heat shock transcription factor HSF1 activation by hsp90 (hsp90 complex) that forms a stress-sensitive complex with HSF1. Cell. 94(4):1998;471-480.
    • (1998) Cell , vol.94 , Issue.4 , pp. 471-480
    • Zou, J.1    Guo, Y.2    Guettouche, T.3    Smith, D.F.4    Voellmy, R.5
  • 34
    • 0029026540 scopus 로고
    • Role of the protein chaperone YDJ1 in establishing hsp90-mediated signal transduction pathways
    • Kimura Y., Yahara I., Lindquist S. Role of the protein chaperone YDJ1 in establishing hsp90-mediated signal transduction pathways. Science. 268(5215):1995;1362-1365.
    • (1995) Science , vol.268 , Issue.5215 , pp. 1362-1365
    • Kimura, Y.1    Yahara, I.2    Lindquist, S.3
  • 35
    • 0030039916 scopus 로고    scopus 로고
    • The 90 kDa heat shock protein (hsp90) modulates the binding of the oestrogen receptor to its cognate DNA
    • Sabbah M., Radanyi C., Redeuilh G., Baulieu E.E. The 90 kDa heat shock protein (hsp90) modulates the binding of the oestrogen receptor to its cognate DNA. Biochem. J. 314(Pt 1):1996;205-213.
    • (1996) Biochem. J. , vol.314 , Issue.PART 1 , pp. 205-213
    • Sabbah, M.1    Radanyi, C.2    Redeuilh, G.3    Baulieu, E.E.4
  • 36
    • 0037150683 scopus 로고    scopus 로고
    • Disassembly of transcriptional regulatory complexes by molecular chaperones
    • Freeman B.C., Yamamoto K.R. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science. 296:2002;2232-2235.
    • (2002) Science , vol.296 , pp. 2232-2235
    • Freeman, B.C.1    Yamamoto, K.R.2
  • 37
    • 0028132140 scopus 로고
    • Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions
    • Lefstin J.A., Thomas J.R., Yamamoto K.R. Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions. Genes Dev. 8(23):1994;2842-2856.
    • (1994) Genes Dev. , vol.8 , Issue.23 , pp. 2842-2856
    • Lefstin, J.A.1    Thomas, J.R.2    Yamamoto, K.R.3
  • 38
    • 0024564101 scopus 로고
    • Steroid hormone receptors compete for factors that mediate their enhancer function
    • Meyer M.E., Gronemeyer H., Turcotte B., Bocquel M.T., Tasset D., Chambon P. Steroid hormone receptors compete for factors that mediate their enhancer function. Cell. 57(3):1989;433-442.
    • (1989) Cell , vol.57 , Issue.3 , pp. 433-442
    • Meyer, M.E.1    Gronemeyer, H.2    Turcotte, B.3    Bocquel, M.T.4    Tasset, D.5    Chambon, P.6
  • 39
    • 0029056558 scopus 로고
    • Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger C.M., Bamberger A.M., de Castro M., Chrousos G.P. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 95(6):1995;2435-2441.
    • (1995) J. Clin. Invest. , vol.95 , Issue.6 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    De Castro, M.3    Chrousos, G.P.4
  • 40
    • 0035810930 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: A mechanism for the generation of glucocorticoid resistance
    • Webster J.C., Oakley R.H., Jewell C.M., Cidlowski J.A. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc. Natl. Acad. Sci. U.S.A. 98(12):2001;6865-6870.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , Issue.12 , pp. 6865-6870
    • Webster, J.C.1    Oakley, R.H.2    Jewell, C.M.3    Cidlowski, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.