Molecular chaperones and subcellular trafficking of steroid receptors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 65, Issue 1-6, 1998, Pages 51-58

  DeFranco, Donald B ^a   Ramakrishnan, Charu ^a   Tang, Yuting ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; DEOXYRIBONUCLEOPROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; STEROID RECEPTOR;

CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; HORMONE RECEPTOR INTERACTION; INTRACELLULAR TRANSPORT; LIGAND BINDING; NONHUMAN; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TARGETING; RAT;

EID: 0032052279     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00177-5     Document Type: Conference Paper

References (66)

1. Hartl F. U. Molecular chaperons in cellular protein folding. Nature. 381:1996;571-580.
2. src with the cellular proteins pp50 and pp90. Curr. Top. Microbiol. Immunol. 123:1986;1-22.
3. Stancato L. F., Chow Y.-H., Hutchinson K. A., Perdew G. H., Jove R., Pratt W. B. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. J. Biol. Chem. 268:1993;21711-21716.
4. Bohen, S. P. and Yamamoto, K. R., Modulation of steroid receptor signal transduction by heat shock proteins. In The Biology of Heat Shock Proteins and Molecular Chaperones, ed. R. I. Morimoto, A. Tissieres, and C. Georgopoulos. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1994, pp. 313-334.
5. Bresnick E. H., Dalman F. C., Sanchez E. R., Pratt W. B. Evidence that the 90 kDa heat shock protein is necessary for the steroid binding conformation of the L-cell glucocorticoid receptor. J. Biol. Chem. 264:1989;4992-4997.
6. Yamamoto K. R. Steroid receptor regulated transcription of genes and gene networks. Ann. Rev. Genet. 19:1985;209-252.
7. Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K., Blumberg B., Kastner P., Mark L., Chambon P., Evans R. M. The nuclear receptor superfamily: The second decade. Cell. 83:1995;835-839.
8. Guiochon-Mantel A., Lescop P., Christin-Maitre S., Loosefelt H., Perrot-Applanat M., Milgrom E. Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J. 10:1991;3851-3859.
9. Chandran U. R., DeFranco D. B. Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons. Mol. Endocrinol. 6:1992;837-844.
10. Madan A. P., DeFranco D. B. Bidirectional transport of glucocorticoid receptors across the nuclear envelope. Proc. Natl. Acad. Sci. U.S.A. 90:1993;3588-3592.
11. Dauvois S., White R., Parker M. G. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J. Cell. Sci. 106:1993;1377-1388.
12. DeFranco, D. B., Madan, A. P., Tang, Y., Chandran, U. R., Xiao, N. and Yang, J., Nucleocytoplasmic shuttling of steroid receptors. In Vitamins and Hormones, vol. 51, ed. G. Litwack. Academic Press, New York, 1995, pp. 315-338.
13. Smith D. F., Toft D. O. Steroid receptors and their associated proteins. Mol. Endocrinol. 7:1993;4-11.
14. Welshons W., Lieberman M. E., Gorski J. Nuclear localization of unoccupied estrogen receptors: Cytochalasin enucleation of GH3 cells. Nature. 307:1984;747-749.
15. Kost S. L., Smith D. F., Sullivan W. P., Welch W. J., Toft D. O. Binding of heat shock proteins to the avian progesterone receptor. Mol. Cell. Biol. 9:1989;3829-3838.
16. Guiochon-Mantel A., Loosfelt H., Lescop P., Sar S., Atger M., Perrot-Applanat M., Milgrom E. Mechanisms of nuclear localization of the progesterone receptor: Evidence for interactions between monomers. Cell. 57:1989;1147-1154.
17. Kang K. I., Devin J., Cadepond F., Jibard N., Guiochon-Mantel A., Baulieu E.-E., Catelli M.-G. In vivo functional protein-protein interaction: Nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus. Proc. Natl. Acad. Sci. U.S.A. 91:1994;340-344.
18. Yang J., DeFranco D. B. Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking. Mol. Endocrinol. 10:1996;3-13.
19. Czar, M. J., Galigniana, M. D., Silverstein, A. M. and Pratt, W. B., Geldanomycin, an hsp90 binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from cytoplasm to nucleus. Biochemistry, 1997, in press.
20. v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. U.S.A. 91:1994;8324-8328.
21. Smith D. F., Whitesell L., Nair S. C., Chen S., Prapapanich V., Rimerman R. A. Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent. Mol. Cell. Biol. 15:1995;6804-6812.
22. Smith D. F. Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol. Endocrinol. 7:1993;1418-1429.
23. Johnson J. L., Toft D. O. Binding of p23 and hsp90 during assembly with the progesterone receptor. Mol. Endocrinol. 9:1995;670-678.
24. Smith D. F., Whitesell L., Nair S. C., Chen S., Prapapanich V., Rimerman R. A. Progesterone receptor structure and function altered by geldanamycin, an hsp90 binding agent. Mol. Cell. Biol. 15:1995;6804-6812.
25. Czar M. J., Lyons R. H., Welsh M. J., Renoir J. M., Pratt W. B. Evidence that the FK506-binding immuophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. Mol. Endocrinol. 9:1995;1549-1560.
26. Melchior F., Gerace L. Mechanisms of nuclear protein import. Curr. Opin. Cell. Biol. 7:1995;310-318.
27. Rexach M., Blobel G. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell. 83:1995;683-692.
28. Beck C. A., Estes P. A., Bona B. J., Muro-Cacho C. A., Nordeen S. K., Edwards D. P. The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology. 133:1993;728-740.
29. Yang J., DeFranco D. B. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen. Mol. Cell. Biol. 14:1994;5088-5098.
30. Imamoto N., Mastsuoka Y., Kurihara T., Kohno K., Miyagi M., Sakiyama F., Okada Y., Tsunasawa S., Yoneda Y. Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins. J. Cell. Biol. 119:1992;1047-1061.
31. Shi Y., Thomas J. O. The transprot of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Mol. Cell. Biol. 12:1992;2186-2192.
32. Shulga N., Roberts P., Gu Z., Spitz L., Tabb M. M., Nomura M., Goldfarb D. S. In vivo nuclear transport kinetics in Saccharomyces cerevisae: A role for heat shock protein 70 during targeting and translocation. J. Cell. Biol. 135:1996;329-339.
33. Picard D., Yamamoto K. R. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6:1987;3333-3340.
34. Ylikomi T., Bocquel M. T., Berry M., Gronemeyer H., Chambon P. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J. 11:1992;3681-3694.
35. Cadepond F., Gasc J. M., Delahaye F., Jibard N., Schweizer G. G., Segard M. I., Evans R., Baulieu E. E. Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. Exp. Cell. Res. 201:1992;99-108.
36. Tang, Y., Ramakrishnan, C., Thomas, J. and DeFranco, D. B., A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation and transrepression defects of a glucocorticoid receptor zinc finger mutant. Mol. Biol. Cell., 1997, 8, in press.
37. Dingwall C., Laskey R. A. Nuclear targeting sequences - A consensus? TIBS. 16:1991;478-481.
38. Moore M. S., Blobel G. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature. 365:1993;661-663.
39. Melchior F., Paschal B., Evans J., Gerace L. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential nuclear factor. J. Cell. Biol. 123:1993;1649-1659.
40. Moore M. S., Blobel G. Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc. Natl. Acad. Sci. U.S.A. 91:1994;10212-10216.
41. Paschal B. M., Gerace L. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. J. Cell. Biol. 129:1995;925-937.
42. Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Euk. Gene. Exp. 7:1997;61-72.
43. Csermely P., Schnaider T., Szanto I. Signalling and transport through the nuclear membrane. Biochim. Biophys. Acta. 1241:1995;425-452.
44. Gasc J.-M., Renoir J.-M., Delahaye F., Baulieu E.-E. Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59. Exp. Cell. Res. 186:1990;362-367.
45. Mandell R. B., Feldherr C. M. Identification of two hsp70-related Xenopus oocyte proteins that are capable of recycling across the nuclear envelope. J. Cell. Biol. 111:1990;1775-1783.
46. Lewis M. J., Pelham H. R. B. Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein. EMBO J. 4:1985;3137-3143.
47. Liu Y., Liang S., Tartakoff A. M. Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ RNA export. EMBO J. 15:1996;6750-6757.
48. Shaknovich R., Shue G., Kohtz S. Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine hsp90 (hsp84). Mol. Cell. Biol. 12:1992;5059-5068.
49. Shue G., Kohtz D. S. Structural and functional aspects of basic helix-loop-helix protein folding by heat shock protein 90. J. Biol. Chem. 269:1994;2707-2711.
50. Landel C. C., Kushner P. J., Greene G. L. The interaction of human estrogen receptor with DNA is modulated by receptor-associated proteins. Mol. Endocrinol. 8:1994;1407-1419.
51. Onate S. A., Estes P. A., Welch W. J., Nordeen S. K., Edwards D. P. Evidence that heat shock protein-70 associated with progesterone receptors is not involved in receptor-DNA binding. Mol. Endocrinol. 5:1991;1993-2004.
52. Srinivasan G., Patel N. T., Thompson E. B. Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex. Mol. Endocrinol. 8:1994;189-196.
53. Edwards D. P., Estes P. A., Fadok V. A., Bona B. J., Onate S., Nordeen S. K., Welch W. J. Heat shock alters the composition of heteromeric steroid receptor complexes and enhances receptor activity in vivo. Biochemistry. 31:1992;2482-2491.
54. Sanchez E. R., Hu J.-L., Zhong S., Shen P., Greene M. J., Housley P. R. Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock. Mol. Endocrinol. 8:1994;408-421.
55. Hu J.-L., Guan X.-J., Sanchez E. R. Enhancement of glucocorticoid receptor-mediated gene expression by cellular stress: Evidence for the involvement of a heat shock-initiated factor or process during recovery from stress. Cell Stress Chap. 1:1996;197-205.
56. Kimura Y., Yahara I., Lindquist S. Role of protein chaperone YDJ1 in establishing hsp90-mediated signal transduction pathways. Science. 268:1995;1362-1365.
57. Caplan A. J., Langley E., Wilson E. M., Vidal J. Hormone-dependent transactivation by the human androgen receptor is regulated by a DnaJ protein. J. Biol. Chem. 270:1995;5251-5257.
58. Danielian P. S., White R., Lees J. A., Parker M. G. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11:1992;1025-1033.
59. van Steensel B., Jenster G., Damm K., Brinkmann A. O., van Driel R. Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix. J. Cell. Biochem. 57:1995;465-478.
60. Tang Y., DeFranco D. B. ATP-dependent release of glucocorticoid receptors from the nuclear matrix. Mol. Cell. Biol. 16:1996;1989-2001.
61. Silver P. A., Way J. C. Eukaryotic DNAJ homologs and the specificity of hsp70 activity. Cell. 64:1993;5-6.
62. Cyr D. M. Cooperation of the molecular chaperone Ydj1 with specific hsp70 homologs to suppress protein aggregation. FEBS Lett. 359:1995;129-132.
63. Freeman B. C., Myers M. P., Schumacher R., Morimoto R. I. Identification of a regulatory motif in hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J. 14:1995;2281-2292.
64. Luisi B. F., Xu W. X., Otwinowski Z., Freedman L. P., Yamamoto K. R., Sigler P. B. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 352:1991;497-505.
65. Rastinejad F., Perlmann T., Evans R. M., Sigler P. B. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 375:1995;203-211.
66. Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D. The crystal structure of the esterogen recetpor DNA-binding domain bound to DNA: How receptors discriminate between their response elements. Cell. 75:1993;567-578.