Estrogen levels do not correlate with improvement in cognition

Archives of Neurology

Volumn 60, Issue 2, 2003, Pages 209-212

  Thal, Leon J ^a,c   Thomas, Ronald G ^b   Mulnard, Ruth ^d   Sano, Mary ^e   Grundman, Michael ^a   Schneider, Lon ^f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; ESTRONE; PLACEBO;

ALZHEIMER DISEASE; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ESTRADIOL BLOOD LEVEL; ESTROGEN BLOOD LEVEL; ESTRONE BLOOD LEVEL; FEMALE; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEUROPSYCHOLOGICAL TEST; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; ALZHEIMER DISEASE; COGNITION DISORDERS; ESTRADIOL; ESTROGENS, CONJUGATED (USP); ESTRONE; FEMALE; HUMANS; POSTMENOPAUSE;

EID: 0037320796     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.60.2.209     Document Type: Article

References (28)

1. Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand. 1987;76:465-479.
2. Luine VN. Estradiol increases choline acetyltransferase activity in specific basal fore-brain nuclei and projection areas of female rats. Exp Neurol. 1985;89:484-490.
3. Toran-Allerand CD, Miranda RC, Benthem WD, et al. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proc Natl Acad Sci U S A. 1992;89:4668-4672.
4. Ditkoff EC, Crary WG, Cristo M, Lobo RA. Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol. 1991;78:991-995.
5. Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology. 1988;13:345-347.
6. Henderson VW, Paganini-Hill A, Miller BL, et al. Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial. Neurology. 2000;54:295-301.
7. Mulnard RA, Cotman CW, Kawas C, et al, for the Alzheimer's Disease Cooperative Study. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized clinical trial. JAMA. 2000;283:1007-1015.
8. Wang PN, Liao SQ, Liu RS, et al. Effects of estrogen on cognition, mood, and cerebral blood flow in AD: a controlled study. Neurology. 2000;54:2061-2066.
9. Asthana S, Craft S, Baker LD, et al. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology. 1999;24:657-677.
10. Asthana S, Baker LD, Craft S, et al. High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology. 2001;57:605-612.
11. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of the patient for the clinician. J Psychiatr Res. 1975;12:189-198.
12. Schneider LS, Olin JT, Doody RS, et al, for the Alzheimer's Disease Cooperative Study. Validity and reliability of the Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change. Alzheimer Dis Assoc Disord. 1997;11 (suppl 2):S22-S31.
13. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984;141:1356-1364.
14. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414.
15. Hamilton J. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;73:56-61.
16. Moss MB, Albert MS, Butters N, Payne M. Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome. Arch Neurol. 1986;43:239-246.
17. Mohs RC, Knopman D, Peterson RC, et al, for the Alzheimer's Disease Cooperative Study. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale (ADAS) that broaden its scope. Alzheimer Dis Assoc Disord. 1997;11 (suppl 2):S13-S21.
18. Army Individual Test Battery: Manual of Directions and Scoring. Washington, DC: War Dept Adjutant General's Office; 1944.
19. Wechsler D. Wechsler Adult Intelligence Scale-Revised. New York, NY: Psychological Corp; 1981.
20. Morris JC, Heyman A, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), I: clinical and neuropsychological assessment of Alzheimer's disease. Neurology. 1989;39:1159-1165.
21. Benton AL, Hamsher K. Multilingual Aphasia Examination Manual. Iowa City: University of Iowa; 1978.
22. Matthews OG, Klove W. Instruction Manual for the Adult Neuropsychological Test Battery. Madison: University of Wisconsin Medical Center; 1964.
23. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson, Ariz: Neuropsychology Press; 1990.
24. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968;114:797-811.
25. Stern Y, Albert SM, Sano M, et al. Assessing patient dependence in Alzheimer's disease. J Gerontol. 1994;49(suppl 5):M216-M222.
26. Fillit H, Weinreb H, Cholst I, et al. Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer's type. Psychoneuroendocrinology. 1986;11:337-345.
27. Yaffe K, Grady D, Pressman A, Cummings S. Serum estrogen levels, cognitive performance, and risk of cognitive decline in older community women. J Am Geriatt Soc. 1998;46:816-821.
28. Hogervorst E, Williams J, Budge M, Riedel W, Jolles J. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in postmenopausal women: a meta-analysis. Neuroscience. 2000;101:485-512.