Mitochondrial disruption and apoptosis in lymphocytes of an HIV infected patient affected by lactic acidosis after treatment with highly active antiretroviral therapy

Journal of Clinical Pathology

Volumn 56, Issue 2, 2003, Pages 147-151

  Tolomeo, M ^a,b   Mancuso, S ^a   Todaro, M ^a   Stassi, G ^a   Catalano, M ^a   Arista, S ^a   Cannizzo, G ^a   Barbusca, E ^a   Abbadessa, V ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; ALANINE AMINOTRANSFERASE; AMYLASE; ANTIRETROVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DIDANOSINE; ETHIDIUM BROMIDE; GAMMA GLUTAMYLTRANSFERASE; INDINAVIR; LACTIC ACID; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE;

ADULT; APOPTOSIS; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CLINICAL FEATURE; ELECTRON MICROSCOPY; ENZYME ANALYSIS; FEMALE; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTIC ACIDOSIS; LYMPHOCYTE; MITOCHONDRION; MORPHOLOGY; PHENOTYPE; PRIORITY JOURNAL; VIRUS LOAD;

ACIDOSIS, LACTIC; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; APOPTOSIS; FEMALE; HIV INFECTIONS; HUMANS; LYMPHOCYTES; MITOCHONDRIA;

EID: 0037313258     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.56.2.147     Document Type: Article

References (32)

1. Lewis W, Simpson JF, Meyer RR. Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine. Circ Res 1994;74:344-8.
2. Nusbaum NJ, Joseph PE. AZT incorporation into mitochondria: study in a human myeloid cell line. DNA Cell Biol 1996;15:363-6.
3. Caffrey PM. Lactic acidosis associated with nucleoside reverse transcriptase inhibitors. J Assoc Nurses AIDS Care 2000;11:91-5.
4. Charton-Bain MC, Flamant M, Aubertin JM, et al. Lactic acidosis and hepatic mitochondrial changes during a treatment with zidovudine. Gastroenterol Clin Biol 1997;21:979-81.
5. Chariot P, Dubreuil-Lemaire AL, Gherardi R. Lactic acidosis and AIDS. Ann Intern Med 1993;119:344-5.
6. Gerard Y, Maulin L, Yazdanpanah Y, et al. Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy. AIDS 2000;14:2723-30.
7. Fulop M. Lactic acidosis and AIDS. Ann Intern Med 1993;119:344-5.
8. Sundar K, Suarez M, Banogon PE, et al. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature. Crit Care Med 1997;25:1425-30.
9. Megarbane B, Goldgran-Toledano D, Guerin JM, et al. Fatal lactic acidosis in a patient infected by HIV and treated with stavudine and didanosine. Pathol Biol (Paris) 2000;48:505-7.
10. Odeh M. Lactic acidosis and acquired immunodeficiency syndrome. J Intern Med 1994;236:478-9.
11. Miller KD, Cameron M, Wood LV, et al. Lactic acidosis and hepatic steotosis associated with use of stavudine: report of four cases. Ann Intern Med 2000;133:192-6.
12. Lonergan JT, Behling C, Pfander H, et al. Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens. Clin Infect Dis 2000;31:162-6.
13. Radovanovic J, Todorovic V, Boricic I, et al. Comparative ultrastructural studies on mitochondrial pathology in the liver of AIDS patients: clusters of mitochondria, protuberances, "minimitochondria," vacuoles, and virus-like particles. Ultrastruct Pathol 1999;23:19-24.
14. Chariot P, Drogou I, de Lacroix-Szmania I, et al. Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion. J Hepatol 1999;30:156-60.
15. Bartley PB, Westacott L, Boots RJ, et al. Large hepatic mitochondrial DNA deletions associated with L-lactic acidosis and highly active antiretroviral therapy. AIDS 2001;15:419-20.
16. Shaer AJ, Rastegar A. Lactic acidosis in the setting of antiretroviral therapy for the acquired immunodeficiency syndrome. A case report and review of the literature. Am J Nephrol 2000;20:332-8.
17. Barile M, Valenti D, Quagliariello E, et al. Mitochondria as cell targets of AZT (zidovudine). Gen Pharmacol 1998;31:531-8.
18. Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1995;1:417-22.
19. Fortgang IS, Belitsos PC, Chaisson RE, et al. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy. Am J Gastroenterol 1995;90:1433-6.
20. Arnaudo E, Dalakas M, Shanske S, et al. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy. Lancet 1991;337:508-10.
21. Shapiro SH, Klavins JV. Concentric membranous bodies and giant mitochondria in hepatocytes from a patient with AIDS. Ultrastruct Pathol 1993;17:557-63.
22. Peters BS, Winer J, Landon DN, et al. Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS. Q J Med 1993;86:5-15.
23. Schroder JM, Bertram M, Schnabel R, et al. Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of zidovudine. Acta Neuropathol (Berl) 1992;85:39-47.
24. Herzberg NH, Zorn I, Zwart R, et al. Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine. Muscle Nerve 1992;15:706-10.
25. Corcuera Pindado MT, Lopez Bravo A, Martinez-Rodriguez R, et al. Histochemical and ultrastructural changes induced by zidovudine in mitochondria of rat cardiac muscle. Eur J Histochem 1994;38:311-18.
26. Pan-Zhou XR, Cui L, Zhou XJ, et al. Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells. Antimicrob Agents Chemother 2000;44:496-503.
27. Gougeon ML, Montagnier L. Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retroviral therapy. Ann N Y Acad Sci 1999;887:199-212.
28. Sloand EM, Young NS, Kumar P, et al. Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication. Blood 1997;89:1357-63.
29. Dhein J, Walczak H, Westendorp MO, et al. Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS. Behring Inst Mitt 1995;96:13-20.
30. Torre D, Zeroli C, Speranza F, et al. Serum levels of Fas/Apo-1 and Bcl-2 in children with HIV-1 infection. Scand J Infect Dis 1998;30:565-8.
31. Gougeon ML. Programmed cell death in HIV infection: dysregulation of BCL-2 and Fas pathways and contribution to AIDS pathogenesis. Psychoneuroendocrinology 1997;22(suppl 1):33-9.
32. Macho A, Castedo M, Marchetti P, et al. Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers. Blood 1995;86:2481-7.