Low-dose hydrocortisone for treatment of chronic fatigue syndrome: A randomized controlled trial

JAMA

Volumn 280, Issue 12, 1998, Pages 1061-1066

  McKenzie, Robin ^a   O'Fallon, Ann ^a   Dale, Janet ^a   Demitrack, Mark ^c   Sharma, Geetika ^a   Deloria, Maria ^a   Garcia Borreguero, Diego ^b   Blackwelder, William ^a   Straus, Stephen E ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; PLACEBO;

ADULT; APPETITE DISORDER; ARTICLE; CHRONIC FATIGUE SYNDROME; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SLEEP DISORDER; TREATMENT OUTCOME; WEIGHT GAIN; WELLBEING;

EID: 0032581975     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.280.12.1061     Document Type: Article

References (34)

1. Straus SE, ed. Chronic Fatigue Syndrome. New York, NY: Marcel Dekker Inc; 1994.
2. Holmes GP, Kaplan JE, Gantz NM, et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387-389.
3. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, for the International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121:953-959.
4. Gunn WJ, Connell DB, Randal IB. Epidemiology of chronic fatigue syndrome: the Centers for Disease Control and Prevention Study. Ciba Found Symp. 1993;173:83-93.
5. Buchwald D, Umali P, Umali J, Pearlman T, Komaroff AL. Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system. Ann Intern Med. 1995;123:81-88.
6. Wessely S. The epidemiology of chronic fatigue syndrome. Epidemiol Rev. 1995;17:139-151.
7. Schluederberg A, Straus SE, Peterson P, et al. NIH Conference: chronic fatigue syndrome research: definition and medical outcome assessment. Ann Intern Med. 1992;117:325-331.
8. Wessely S. Chronic fatigue syndrome: summary of a report of a Joint Committee of the Royal Colleges of Physicians, Psychiatrists and General Practitioners. J R Coll Physicians Lond. 1996;30:497-504.
9. Straus SE, Tosato G, Armstrong G, et al. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med. 1985;102:7-16.
10. Straus SE, Dale JK, Tobi M, et al. Acyclovir treatment of the chronic fatigue syndrome: lack of efficacy in a placebo-controlled trial. N Engl J Med. 1988;319:1692-1698.
11. Mawle AC, Nisenbaum R, Dobbins JG, et al. Seroepidemiology of chronic fatigue syndrome: a case-control study. Clin Infect Dis. 1995;21:1386-1389.
12. Strober W. Immunological function in chronic fatigue syndrome. In: Straus SE, ed. Chronic Fatigue Syndrome. New York, NY: Marcel Dekker Inc; 1994:207-240.
13. Tirelli U, Marotta G, Improta S, Pinto A. Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol. 1994;40:601-608.
14. Mawle AC, Nisenbaum R, Dobbins JG, et al. Immune responses associated with chronic fatigue syndrome: a case-control study. J Infect Dis. 1997;175:136-141.
15. Demitrack MA, Dale JK, Straus SE, Laue L, Listwak SJ, Kruesi MJP. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab. 1991;73:1224-1234.
16. Taerk GS, Toner BB, Salit IE, Garfinkel PE, Ozersky S. Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis). Int J Psychiatry Med. 1987;17:49-56.
17. Kruesi MJP, Dale JK, Straus SE. Psychiatric diagnoses in patients who have the chronic fatigue syndrome. J Clin Psychiatry. 1989;50:53-56.
18. Carroll BJ, Curtis GC, Mendels J. Neuroendocrine regulation in depression, I: limbic system-adrenocortical dysfunction. Arch Gen Psychiatry. 1976;33:1309-1344.
19. Crofford LJ, Pillemer SR, Kalogeras KT, et al. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum. 1994;37:1583-1592.
20. Joseph-Vanderpool JR, Rosenthal NE, Chrousos GP, et al. Abnormal pituitary-adrenal responses to CRH in patients with seasonal affective disorder: clinical and pathophysiological implications. J Clin Endocrinol Metab. 1991;72:1382-1387.
21. Leese G, Chattington P, Fraser W, Vora J, Edwards R, Williams G. Short-term nightshift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome. J Clin Endocrinol Metab. 1996;81:1867-1870.
22. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Association; 1987.
23. McNair DM, Lorr M, Droppleman LF. Profile of Mood States. San Diego, Calif: Educational and Industrial Testing Service; 1981.
24. Derogatis LR. SCL-90-R Administration, Scoring, and Procedures Manual-I; for the Revised Version. Baltimore, Md: LR Derogatis; 1977.
25. Bergner M, Bobbitt RA, Kressel S, Pollard WE, Gilson BS, Morris JR. The Sickness Impact Profile: conceptual formulation and methodology for the development of a health status measure. Int J Health Serv. 1976;6:393-415.
26. Beck A, Ward C, Mendelson M, Mock J, Erbaugh J. A scale for measuring depression. Arch Gen Psychiatry. 1961;4:561-571.
27. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
28. The Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther. 1972;13:694-698.
29. Peterson PK, Shepard J, Macres M, et al. A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Am J Med. 1990;89:554-560.
30. Sharpe M, Hawton K, Simkin S, et al. Cognitive behavioural therapy for the chronic fatigue syndrome: a randomized controlled trial. BMJ. 1996;312:22-26.
31. Vercoulen JHMM, Swanink CMA, Zitman FG, et al. A randomized, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. Lancet. 1996;347:858-861.
32. Jeffries WM. Low-dosage glucorticoid therapy: an appraisal of its safety and mode of action in clinical disorders, including rheumatoid arthritis. Arch Intern Med. 1967;119:265-278.
33. Taylor AL, Fishman LM. Corticotropin-releasing hormone. N Engl J Med. 1988;319:213-222.
34. Baram TZ, Mitchell WG, Haden E. Inhibition of pituitary-adrenal secretion by a corticotropin releasing hormone antagonist in humans. Mol Psychiatry. 1996;1:320-324.