The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses

Experimental and Molecular Pathology

Volumn 74, Issue 1, 2003, Pages 40-48

  Trebicz Geffen, Meirav ^a   Nevo, Zvi ^a   Evron, Zoharia ^a   Posternak, Natalia ^a   Glaser, Tova ^a   Fridkin, Mati ^c   Kollander, Yehuda ^d   Robinson, Dror ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b ASSAF HAROFEH MEDICAL CENTER   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA; BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, RAT; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; EXOSTOSIN 1; EXOSTOSIN-1; FGFR3 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; N ACETYLGLUCOSAMINYLTRANSFERASE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; NOS2A PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL POPULATION; CONTROLLED STUDY; GENE EXPRESSION; HEREDITARY MULTIPLE EXOSTOSIS; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYME CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; RAT; STEM CELL; ANIMAL; CARTILAGE; DISEASE MODEL; GENETICS; HINDLIMB; METABOLISM; OSTEOCHONDROMA; PATHOLOGY; PHYSIOLOGY; RADIOGRAPHY;

ERINACEIDAE;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CARTILAGE; DISEASE MODELS, ANIMAL; EXOSTOSES, MULTIPLE HEREDITARY; HINDLIMB; HUMANS; N-ACETYLGLUCOSAMINYLTRANSFERASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOCHONDROMA; PROTEIN-TYROSINE KINASES; RATS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECEPTORS, FIBROBLAST GROWTH FACTOR; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037312686     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4800(03)80007-2     Document Type: Article

References (41)

1. Ahn J., Ludecke H., Lindow S., Horton W.A., Lee B., Wagner M.J., Horsthemke B., and Wells D.E. Cloning of the putative tumor suppressor gene for hereditary multiple exostoses (EXT1) Nat. Genet. 11 1995 137 143
2. Amin A.R., Attur M., and Abramson S.B. Nitric oxide synthase and cyclooxygenases: Distribution, regulation, and intervention in arthritis Curr. Opin. Rheumatol. 11 1999 202 209
3. Amling M., Neff L., Tanaka S., Inoue D., Kuida K., Weir E., Philbrick W.M., Broadus A.E., and Baron R. Bcl-2 lies downstream of parathyroid hormone related peptide in a signalling pathway that regulates chondrocyte maturation during skeletal development J. Cell Biol. 136 1997 205 213
4. Bohay D.R., Johnson K.D., and Manoli A. The traumatic bunion Foot Ankle Int. 17 1996 383 387
5. Bovee J.V.M.G., Van Den Broek L.J.C.M., Cleton-Jansen A.M., and Hogendoorn P.C.W. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma Lab. Invest. 80 2000 1925 1934
6. Buhler E.M., and Malik N.J. The Tricho-Rhino-Phalangeal syndrome(s): Chromosome 8 long arm deletion: Is there a shortest region of overlap between reported cases? TRP I and TRP II syndromes: Are they separate entities? Am. J. Med. Genet. 19 1984 113 119
7. Cook A., Raskind W., Blanton S.H., Pauli R.M., Gregg R.G., Francomano C.A., Puffenberger E., Conrad E.U., Schmale G., Schellenberg G., Wijsman E., Hecht J.T., Wells D., and Wagner M.J. Genetic heterogeneity in families with hereditary multiple exostoses Am. J. Hum. Genet. 53 1993 71 79
8. Delgado E., Rodriguez J.I., Rodriguez J.L., Miralles C., and Paniagua R. Osteochondroma induced by reflection of the perichondrial young rat radii Calcif. Tissue Int. 40 1987 85 90
9. Delgado E., Rodriguez J.I., Serrada A., Tellez M., and Pariagua R. Radiation-induced osteochondroma-like lesion in young rats Clin. Orthop. 201 1985 251 258
10. Erlebacher A., Flivaroff E.H., Gitelman S.E., and Derynck R. Toward a molecular understanding of skeletal development Cell 80 1995 371 378
11. Givol D., and Yayon A. Complexity of FGF receptors: Genetic basis for structural diversity and functional specificity FASEB J. 7 1992 3362 3369
12. Harlow D., and Lane D. Antibodies: A Laboratory Manual 1988 Cold Spring Harbor Laboratory New York
13. Horton W.E.J., Udo I., Precht P., Balakir R., and Hasty K. Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulation In Vitro Cell Dev. Biol. Anim. 34 1998 378 384
14. Kobayashi S., Morimoto K., Shimizu T., Takahashi M., Kurosawa H., and Shirasawa T. Association of EXT1 and EXT2, hereditary multiple exostoses gene products, in Golgi apparatus Biochem. Biophys. Res. Commun. 268 2000 860 867
15. Kroncke K.D., Feshel K., Suschek C., and Kolb-Bachofen V. Inducible nitric oxide synthase derived nitric oxide in gene regulation, cell death and cell survival Int. Immunopharmacol. 1 2001 1407 1420
16. Kroncke K.D., Suschek C.V., and Kolb-Bachofen V. Implications of inducible nitric oxide synthase expression and enzyme activity Antioxide Redox Signal 2 2000 585 605
17. Laroux F.S., Pavlick K.P., Hones I.N., Kawachi S., Harada H., Bharwani S., Hoffman J.M., and Grisham M.B. Role of nitric oxide in inflammation Acta Physiol. Scand. 173 2001 113 118
18. LeMerre M., Legeai-Mallet L., Jeannin P.M., Horsthemke B., Schinzel A., Plauchu H., Toutain A., Achard F., Munnich A., and Maroteaux P. A gene for hereditary multiple exostoses maps to Chromosome 19p Hum. Mol. Genet. 3 1994 717 722
19. Ludecke H.J., Johnson C., Wagner M.J., Wells D.E., Turleau C., Tommerup N., Latos-Bielenska A., Sandig K.R., Meinecke P., Zabel B., and Horsthemke B. Molecular definition of the shortest region of deletion overlap in the Langer-Giedion syndrome Am. J. Hum. Genet. 49 1991 1197 1206
20. McCormick C., Leduc Y., Martinidale D., Mattison K., Esford L.E., Dyer A.P., and Tufaro F. The putative tumor suppressor EXT1 alters the expression of cell-surface heparan sulfate Nat. Genet. 19 1998 158 161
21. Milgram J.W. The origins of osteochondromas and enchondromas: A histopathologic study Clin. Orthop. 174 1983 264 284
22. Parrish J.E., Wagner M.J., Hecht J.T., Scott C.I. Jr., and Wells D.E. Molecular definition of overlapping chromosomal deletions in patients with Langer-Giedion syndrome Genomics 11 1991 54 61
23. Peters K., Ornitz D., Werner S., and Williams L.T. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis Dev. Biol. 155 1993 423 430
24. Porter D.E., Emerton M.E., Villanueva-Lopez F., and Simpson A.H. Clinical and radiographic analysis of osteochondromas and growth disturbance in hereditary multiple exostoses J. Pediatr. Orthop. 20 2000 246 250
25. Porter D.E., and Simpson A.H. The neoplastic pathogenesis of solitary and multiple osteochondromas J. Pathol. 188 1999 119 125
26. Radomski M.W., Palmer R.M., and Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells Natl. Acad. Sci. USA 87 1990 10043 10047
27. Riley E.H., Lane J.M., Urist M.R., Lyons K.M., and Lieberman J.R. Bone morphogenic protein-2: Biology and applications Clin. Orthop. 324 1996 39 46
28. Riley B.B., Savage M.P., Simand B.K., Olwin B.B., and Fallon J.F. Retroviral expression of FGF-2 (bFGF) affects patterning in chick limb bud Development 118 1993 95 104
29. Robinson D., Halperin N., and Nevo Z. Regenerating hyaline cartilage in articular defects of old chickens using implants of embryonal chick chondrocytes embedded in a new natural delivery substance Calcif. Tissue Int. 46 1990 246 253
30. Robinson D., Hasharoni A., Halperin N., Yayon A., and Nevo Z. Mesenchymal cells and growth factors in bunions Foot Ankle 20 1999 727 732
31. Robinson D., Hasharoni A., Oganesian A., Sandell L.J., Yayon A., and Nevo Z. Osteochondroma formation - The role of FGF9 and FGF receptor Orthopedics 24 2001 783 787
32. Robinson D., Tieder M., Halperin N., Burshtein D., and Nevo Z. Maffucci's syndrome - The result of neural abnormalities? Evidence of mitogenic neurotransmitters present in enchondromas and soft tissue hemangiomas Cancer 74 1994 949 957
33. Shiang R., Thompson L.M., Zhu Y.Z., Church D.M., Fielder T.J., Bocian M., Winokur S.T., and Wasmuth J.J. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism - Achondroplasia Cell 78 1994 335 342
34. Solomon L. Hereditary multiple exostosis J. Bone Joint Surg. A 45 1963 292 304
35. Stickens D., Clines G., Burbee D., Ramos P., Thomas S., Hogue D., Hecht J.T., Lovett M., and Evans G.A. The EXT2 multiple exostoses gene defines a family of putative tumor suppressor genes Nat. Genet. 14 1996 25 32
36. Studer R.K., Jaffurs D., Stefanovic-Racic M., Robbins P.D., and Evans C.H. Nitric oxide in osteoarthritis Osteoarthritis Cartilage 7 1999 377 379
37. Terlikowski S.J. Tumor necrosis factor and cancer treatment: A historical review and perspectives Rocz. Akad. Med. Bialymst. 46 2001 5 18
38. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications Proc. Natl. Acad. Sci. USA 76 1979 4350 4354
39. van der Eerden B.C.J., Karperien M., Gevers E.F., Lowik C.W.G.M., and Wit J.M. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth J. Bone Miner. Res. 15 2000 1045 1055
40. Wu Y.Q., Heutink P., De Vries B.B., Sandkuijl L.A., van der Ouweland A.M., Niermeijer M.F., Galjaard H., Reyniers E., Willems P.J., and Halley D.J. Assignment of a second locus for multiple exostoses to the pericentromeric region of chromosome 11 Hum. Mol. Genet. 3 1994 167 171
41. Wuyts W., Van Hul W., Wauters J., Nemtsova M., Reynier S.E., Van Hul E., De Boule K., De Vries B.B.A., Hendrickx J., Herrygers I., Bossuyt P., Balemans W., Fransen E., Vits L., Coucke P., Nowak N.J., Shows T.B., Mallet L., van der Ouweland A.M.W., McGaughrn J., Halley D.J.J., and Willems P. Positional cloning of a gene involved in hereditary multiple exostoses Hum. Mol. Genet. 5 1996 1547 1557