Characterization of Histatin 5 with Respect to Amphipathicity, Hydrophobicity, and Effects on Cell and Mitochondrial Membrane Integrity Excludes a Candidacidal Mechanism of Pore Formation

Journal of Biological Chemistry

Volumn 276, Issue 8, 2001, Pages 5643-5649

  HelmerhorsHMt, Eva J ^a   Van'T Hof, Wim ^b   Breeuwer, Pieter ^c   Veerman, Enno C I ^b   Abee, Tjakko ^c   Troxler, Robert F ^a   Amerongen, Arie V Nieuw ^b   Oppenheim, Frank G ^a  

^a BOSTON UNIVERSITY   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BODY FLUIDS; CELLS; FUNGUS PROTECTION; HYDROPHOBICITY; YEAST;

AMPHIPATHICITY;

PROTEINS;

AMPHOPHILE; ANTIFUNGAL AGENT; DHVAR1 PEPTIDE; DHVAR4 PEPTIDE; GLYCINE; HISTATIN; HISTATIN 5; LEUCINE; PGLA PEPTIDE; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; SALIVA PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIFUNGAL ACTIVITY; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; FUNGICIDAL ACTIVITY; HYDROPHOBICITY; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SALIVA; CANDIDA ALBICANS; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; INTRACELLULAR MEMBRANE; MITOCHONDRION; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

FUNGI;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CELL MEMBRANE; INTRACELLULAR MEMBRANES; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; SALIVARY PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035937109     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008229200     Document Type: Article

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