Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity

Journal of Immunology

Volumn 170, Issue 3, 2003, Pages 1218-1223

  Holzer, Ursula ^a   Kwok, William W ^a   Nepom, Gerald T ^a   Buckner, Jane Hoyt ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEMAGGLUTININ; INTERLEUKIN 2; INTERLEUKIN 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ARTICLE; CYTOKINE PRODUCTION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INFLUENZA VIRUS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; VACCINATION;

EID: 0037310719     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.3.1218     Document Type: Article

References (31)

1. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
2. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
3. + T-cell subsets in vivo. Immunol. Rev. 123:189.
4. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579.
5. + T cells. J. Exp. Med. 182:1591.
6. Rogers, P. R., G. Huston, and S. L. Swain. 1998. High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines. J. Immunol. 161:3844.
7. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
8. + T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4237.
9. Rogers, P. R., and M. Croft. 2000. CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol. 164:2955.
10. Rogers, P. R., and M. Croft. 1999. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J. Immunol. 163:1205.
11. Webb, L. M., and M. Feldmann. 1995. Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells. Blood 86:3479.
12. + cells. Eur. J. Immunol. 25:587.
13. Boyton, R. J., N. Zaccai, E. Y. Jones, and D. M. Altmann. 2002. CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR α-chain complementarity-determining region 3. J. Immunol. 168:1018.
14. Schulze-Koops, H., P. E. Lipsky, and L. S. Davis. 1998. Human memory T cell differentiation into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by TCR ligation. Eur. J. Immunol. 28:2517.
15. Kwok, W. W., A. W. Liu, E. J. Novak, J. A. Gebe, R. A. Ettinger, G. T. Nepom, S. N. Reymond, and D. M. Koelle. 2000. HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells. J. Immunol. 164:4244.
16. Reichstetter, S., R. A. Ettinger, A. W. Liu, J. A. Gebe, G. T. Nepom, and W. W. Kwok. 2000, Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response. J. Immunol. 165:6994.
17. Rulifson, I. C., A. I. Sperling, P. E. Fields, F. W. Fitch, and J. A. Bluestone. 1997. CD28 costimulation promotes the production of Th2 cytokines. J. Immunol. 158:658.
18. Fowell, D. J., J. Magram, C. W. Turck, N. Killeen, and R. M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity 6:559.
19. Howland, K. C., L. J. Ausubel, C. A. London, and A. K. Abbas. 2000. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J. Immunol. 164:4465.
20. Dong, C., A. E. Juedes, U. A. Temann, S. Shresta, J. P. Allison, N. H. Ruddle, and R. A. Flavell. 2001. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409:97.
21. McArthur, J. G., and D. H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178:1645.
22. Rivas, F. V., S. O'Herrin, and T. F. Gajewski. 2001. CD28 is not required for c-Jun N-terminal kinase activation in T cells. J. Immunol. 167:3123.
23. Schweitzer, A. N., and A. H. Sharpe. 1998. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J. Immunol. 161:2762.
24. Skapenko, A., P. E. Lipsky, H. G. Kraetsch, J. R. Kalden, and H. Schulze-Koops. 2001. Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation. J. Immunol. 166:4283.
25. Lindstein, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
26. Diehn, M., A. A. Alizadeh, O. J. Rando, C. L. Liu, K. Stankunas, D. Botstein, G. R. Crabtree, and P. O. Brown. 2002. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc. Natl. Acad. Sci. USA 99:11796.
27. + T cell subsets. J. Exp. Med. 168:1659.
28. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
29. Balamuth, F., D. Leitenberg, J. Unternaehrer, I. Mellman, and K. Bottomly. 2001. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 15:729.
30. Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283:680.
31. Iezzi, G., E. Scotet, D. Scheidegger, and A. Lanzavecchia. 1999. The interplay between the duration of TCR and cytokine signaling determines T cell polarization. Eur. J. Immunol. 29:4092.