Human memory T cell differentiation into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by TCR ligation

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2517-2529

  Schulze Koops, Hendrik ^a   Lipsky, Peter E ^a   Davis, Laurie S ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cytokine; Human; Memory; Th2

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ARTICLE; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; RECEPTORS, ANTIGEN, T-CELL; TH2 CELLS;

EID: 0031879606     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2517::AID-IMMU2517>3.0.CO;2-5     Document Type: Article

References (38)

1. Sanders, M. E., Makgoba, M. W. and Shaw, S., Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol. Today 1988. 9: 195-199.
2. Seder, R. A. and Paul, W. E., Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 1994. 12: 635-673.
3. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 2348-2357.
4. Del Prete, G. F., De Carli, M., Ricci, M. and Romagnani, S., Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of TM clones is limited by their cytolytic capacity. J. Exp. Med. 1991. 174: 809-813.
5. Street, N. E., Schumacher, J. H., Fong, T. A., Bass, H., Fiorentino, D. F., Leverah, J. A. and Mosmann, T. R., Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J. Immunol. 1990. 144: 1629-1639.
6. van der Veen, R. C. and Stohlman, S. A., Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10. J. Neuroimmunol. 1993. 48: 213-220.
7. Schulze-Koops, H., Lipsky, P. E., Kavanaugh, A. F. and Davis, L. S., Elevated Th1-or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis: Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J. Immunol. 1995. 155: 5029-5037.
8. Simon, A. K., Seipelt, E. and Sieper, J., Divergent T-cell cytokine patterns in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 1994. 91: 8562-8566.
9. Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D. and Paul, W. E., Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 1990. 172: 921-929.
10. Swain, S. L., Weinberg, A. D., English, M. and Huston, G., IL-4 directs the development of Th2-like helper effectors. J. Immunol. 1990. 145: 3796-3806.
11. Perez, V. L., Lederer, J. A., Lichtman, A. H. and Abbas, A. K., Stability of Th1 and Th2 populations. Int. Immunol. 1995. 7: 869-875.
12. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M., Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
13. Constant, S., Pfeiffer, C., Woodard, A., Pasqualini, T. and Bottomly, K., Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J. Exp. Med. 1995. 182: 1591-1596.
14. Chang, T. L., Shea, C. M., Urioste, S., Thompson, R. C., Boom, W. H. and Abbas, A. K., Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2 and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells. J. Immunol. 1990. 145: 2803-2808.
15. Rulifson, I. C., Sperling, A. I., Fields, P. E., Fitch, F. W. and Bluestone, J. A., CD28 costimulation promotes the production of Th2 cytokines. J. Immunol. 1997. 158: 658-665.
16. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N. and Glimcher, L. H., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995. 80: 707-718.
17. Tite, J. P., Foellmer, H. G., Madri, J. A. and Janeway, C. A. Jr., Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen. J. Immunol. 1987. 139: 2892-2898.
18. Scott, B., Liblau, R., Degermann, S., Marconi, L. A., Ogata, L., Caton, A. J., McDevitt, H. O. and Lo, D., A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1994. 1: 73-83.
19. Brinkmann, V. and Kristofic, C., Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets. J. Immunol. 1995. 155: 3322-3328.
20. Tortorella, C., Schulze-Koops, H., Thomas, R., Splawski, J. B., Davis, L. S., Picker, L. J. and Lipsky, P. E., Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation. J. Immunol. 1995. 155: 149-162.
21. Geppert, T. D. and Lipsky, P. E., Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. J. Immunol. 1987. 138: 1660-1666.
22. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B. and Mak, T. W., Differential T cell costimulatory requirements in CD28-deficient mice. Science 1993. 261: 609-612.
23. Ronchese, F., Hausmann, B., Hubele, S. and Lane, P., Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 1994. 179: 809-817.
24. Gollob, K. J. and Coffman, R. L., A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells. J. Immunol. 1994. 152: 5180-5188.
25. Croft, M. and Swain, S. L., Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J. Immunol. 1995. 154: 4269-4282.
26. Yoshimoto, T. and Paul, W. E., CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 1994. 179: 1285-1295.
27. Brinkmann, V., Kinzel, B. and Kristofic, C., TCR-independent activation of human CD4+ 45RO-T cells by anti-CD28 plus IL-2: Induction of clonal expansion and priming for a Th2 phenotype. J. Immunol. 1996. 156: 4100-4106.
28. Bradley, L. M., Yoshimoto, K. and Swain, S. L., The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 1995. 155: 1713-1724.
29. Macatonia, S. E., Hsieh, C. S., Murphy, K. M. and O'Garra, A., Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int. Immunol. 1993. 5: 1119-1128.
30. Seder, R. A., Paul, W. E., Davis, M. M. and Fazekas de St. Groth, B., The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 1992. 176: 1091-1098.
31. Gajewski, T. F. and Fitch, F. W., Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 1988. 140: 4245-4252.
32. + cells. Eur. J. Immunol. 1995. 25: 587-595.
33. Lenschow, D. J., Herold, K. C., Rhee, L., Patel, B., Koons, A., Qin, H. Y., Fuchs, E., Singh, B., Thompson, C. B. and Bluestone, J. A., CD28/B7 regulation of Th 1 and Th2 subsets in the development of autoimmune diabetes. Immunity 1996. 5: 285-293.
34. Lane, P., Burdet, C., Hubele, S., Scheidegger, D., Muller, U., McConnell, F. and Kosco-Vilbois, M., B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells. J. Exp. Med. 1994. 179: 819-830.
35. Lu, P., Zhou, X., Chen, S. J., Moorman, M., Morris, S. C., Finkelman, F. D., Linsley, P., Urban, J. F. and Gause, W. C., CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 1994. 180: 693-698.
36. Van der Pouw-Kraan, T., Van Kooten, C., Rensink, I. and Aarden, L., Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production. Eur. J. Immunol. 1992. 22: 1237-1241.
37. Rosenberg, S. A. and Lipsky, P. E., Monocyte dependence of pokeweed mitogen-induced differentiation of immunoglobulin-secreting cells from human peripheral blood mononuclear cells. J. Immunol. 1979. 122: 926-931.
38. Davis, L. S., Vida, R. and Lipsky, P. E., Regulation of human T lymphocyte mitogenesis by antibodies to CDS. J. Immunol. 1986. 137: 3758-3767.