The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiation

Blood

Volumn 101, Issue 3, 2003, Pages 1111-1117

  Erkeland, Stefan J ^a   Valkhof, Marijke ^a   Heijmans Antonissen, Claudia ^a   Delwel, Ruud ^a   Valk, Peter J M ^a   Hermans, Mirjam H A ^a   Touw, Ivo P ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; LUCIFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR YIN YANG 1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL TRANSFORMATION; COLONY FORMING CELL; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ASSAY; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE INSERTION; GENETIC CODE; GENETIC DISORDER; GENETIC TRANSFECTION; LEUKEMIA; LEUKEMIA CELL; LYMPHOMA; MOUSE; MURINE LEUKEMIA VIRUS; MUTAGENESIS; MYELOPOIESIS; NEUTROPHIL; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RETROVIRUS; STEM CELL; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; VIRUS DNA CELL DNA INTERACTION;

EID: 0037307086     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-04-1207     Document Type: Article

References (44)

1. Lowenberg B, Downing JR, Burnett A. Acute myeloid leukemia. N Engl J Med. 1999;341:1051-1062.
2. Jonkers J, Berns A. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta. 1996;1287:29-57.
3. Largaespada DA. Genetic heterogeneity in acute myeloid leukemia: maximizing information flow from MuLV mutagenesis studies. Leukemia. 2000;14:1174-1184.
4. Li J, Shen H, Himmel KL, et al. Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet. 1999;23:348-353.
5. Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278:1059-1064.
6. Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G. Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol. 2001;21:224-234.
7. Fujino T, Yamazaki Y, Largaespada DA, et al. Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. Exp Hematol. 2001;29:856-863.
8. Nucifora G. The EVI1 gene in myeloid leukemia. Leukemia. 1997;11:2022-2031.
9. Bruckert P, Kappler R, Scherthan H, et al. Double minutes and c-MYC amplification in acute myelogenous leukemia: are they prognostic factors? Cancer Genet Cytogenet. 2000;120:73-79.
10. Ru M, Shustik C, Rassart E. Graffi murine leukemia virus: molecular cloning and characterization of the myeloid leukemia-inducing agent. J Virol. 1993;67:4722-4731.
11. Denicourt C, Edouard E, Rassart E. Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration. J Virol. 1999;73:4439-4442.
12. Austen M, Luscher B, Luscher-Firzlaff JM. Characterization of the transcriptional regulator YY1: the bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding protein. J Biol Chem. 1997;272:1709-1717.
13. Shi Y, Lee JS, Galvin KM. Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta. 1997;1332:F49-F66.
14. Thomas MJ, Seto E. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene. 1999;236:197-208.
15. Donohoe ME, Zhang X, McGinnis L, et al. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999;19:7237-7244.
16. Yao YL, Dupont BR, Ghosh S, et al. Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. Nucleic Acids Res. 1998;26:3776-3783.
17. Safrany G, Perry RP. Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. Proc Natl Acad Sci U S A. 1993;90:5559-5563.
18. Saffer JD, Jackson SP, Annarella MB. Developmental expression of Sp1 in the mouse. Mol Cell Biol. 1991;11:2189-2199.
19. Shrivastava A, Calame K. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 1994;22:5151-5155.
20. Petkova V, Romanowski MJ, Sulijoadikusumo I, et al. Interaction between YY1 and the retinoblastoma protein: regulation of cell cycle progression in differentiated cells. J Biol Chem. 2000;276:7932-7936.
21. Yao YL, Yang WM, Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol. 2001;21:5979-5991.
22. Joosten M, Valk PJ, Vankan Y, et al. Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a novel panel of cas-Br-M murine leukemia virus-infected mice. Virology. 2000;268:308-318.
23. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques. 1989;7:980-986, 989.
24. Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 1990;18:3587-3596.
25. Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci U S A. 1983;80:2931-2935.
26. de Koning JP, Soede-Bobok AA, Ward AC, et al. STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1). Oncogene. 2000;19:3290-3298.
27. Hermans MH, Ward AC, Antonissen C, et al. Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropena. Blood. 1998;92:32-39.
28. Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics. 1997;45:17-23.
29. Chono H, Yoshioka H, Ueno M, Kato I. Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34(+)CD38(-) bone marrow cells. J Biochem (Tokyo). 2001;130:331-334.
30. de Wet JR, Wood KV, DeLuca M, Helinski DR, Subramani S, Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol. 1987;7:725-737.
31. van der Eb AJ, Graham FL, Assay of transforming activity of tumor virus DNA. Methods Enzymol. 1980;65:826-839.
32. Barge RM, de Koning JP, Pouwels K, et al. Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21 ras route. Blood. 1996;87:2148-2153.
33. Lowenberg B, van Putten WL, Touw IP, Delwel R, Santini V. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. N Engl J Med. 1993;328:614-619.
34. Valk PJ, Vankan Y, Joosten M, et al. Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2. J Virol. 1999;73:3595-3602.
35. Ward AC, Smith L, de Koning JP, van Aesch Y, Touw IP. Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells. J Biol Chem. 1999;274:14956-14962.
36. Yang WM, Yao YL, Seto E. The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. EMBO J. 2001;20:4814-4825.
37. Garcia E, Marcos-Gutierrez C, del Mar LM, Moreno JC, Vidal M. RYBR, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999;18:3404-3418.
38. David G, Alland L, Hong SH, et al. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998;16:2549-2556.
39. Wu WS, Vallian S, Seto E, et al. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001;21:2259-2268.
40. Gelmetti V, Zhang J, Fanelli M, et al. Aberrant recruitment of the nuclear receptor corepressorhistone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol. 1998;18:7185-7191.
41. Amann JM, Nip J, Strom DK, et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol. 2001;21:6470-6483.
42. Shrivastava A, Saleque S, Karpana GV, et al. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science. 1993;262:1889-1892.
43. Shrivastava A, Yu J, Artandi S, Calame K. YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels. Proc Natl Acad Sci U S A. 1996;93:10638-10641.
44. Mori A, Higashi H, Hoshikawa Y, et al, Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue, Oncogene, 1999;18:6209-6221.