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Volumn 8, Issue 1, 2003, Pages 55-59

High-throughput measurement of drug pKa values for ADME screening

Author keywords

ADME; Drug absorption; Ionization constant

Indexed keywords

ANTIFUNGAL AGENT; DIMETHYL SULFOXIDE; ITRACONAZOLE; LABETALOL; NITROFURANTOIN; SILDENAFIL; VASODILATOR AGENT;

EID: 0037306865     PISSN: 15355535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-5535(04)00243-6     Document Type: Article
Times cited : (22)

References (16)
  • 1
    • 0035150465 scopus 로고    scopus 로고
    • High-throughput physicochemical profiling for drug discovery
    • Kerns, E.H. high-throughput physicochemical profiling for drug discovery. J. Pharm. Sci. 90(11), 1838, 2001.
    • (2001) J. Pharm. Sci. , vol.90 , Issue.11 , pp. 1838
    • Kerns, E.H.1
  • 3
    • 0033943390 scopus 로고    scopus 로고
    • Physicochemical characterization of sildenafil: Ionization, lipophilicity behavior, and ionic-partition dia gram studied by two-phase titration and electrochemistry
    • Gobry, V., Bouchard, G., Carrupt, P.A., Testa, B., Girault, H.H. Physicochemical characterization of sildenafil: Ionization, lipophilicity behavior, and ionic-partition dia gram studied by two-phase titration and electrochemistry. Helv. Chim. Acta, 83(7), 1465, 2000.
    • (2000) Helv. Chim. Acta , vol.83 , Issue.7 , pp. 1465
    • Gobry, V.1    Bouchard, G.2    Carrupt, P.A.3    Testa, B.4    Girault, H.H.5
  • 4
    • 0032146512 scopus 로고    scopus 로고
    • Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants of Ionizable Drugs
    • Allen, R.I., Box, K.J,. Comer, J.E.A., Peake, C., Tam, K.Y. Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants of Ionizable Drugs. J. Pharm. Biomed. Anal. 17, 699, 1998.
    • (1998) J. Pharm. Biomed. Anal. , vol.17 , pp. 699
    • Allen, R.I.1    Box, K.J.2    Comer, J.E.A.3    Peake, C.4    Tam, K.Y.5
  • 5
    • 0034886798 scopus 로고    scopus 로고
    • An integrated process for measuring the physicochemical properties of drug candidates in a preclini cal discovery environment
    • Kibbey, C. E., Poole, S.K., Robinson, B., Jackson, J D., Durham, D. An integrated process for measuring the physicochemical properties of drug candidates in a preclini cal discovery environment. J. Pharm. Sci. 90(8), 1164, 2001.
    • (2001) J. Pharm. Sci. , vol.90 , Issue.8 , pp. 1164
    • Kibbey, C.E.1    Poole, S.K.2    Robinson, B.3    Jackson, J.D.4    Durham, D.5
  • 6
    • 0037442580 scopus 로고    scopus 로고
    • High-throughput Measurement of pKa values in a mixed-buffer linear pH gradient system
    • in press
    • Box, K., Bevan, C., Comer, J. Hill, A., Allen, R., Reynolds, D. high-throughput Measurement of pKa values in a mixed-buffer linear pH gradient system. Anal. Chem. 2003, in press.
    • (2003) Anal. Chem.
    • Box, K.1    Bevan, C.2    Comer, J.3    Hill, A.4    Allen, R.5    Reynolds, D.6
  • 7
    • 26544477095 scopus 로고    scopus 로고
    • Analytical method and apparatus therefor
    • International Patent Application No. WO99/13328
    • Hill, A., Bevan, C., Reynolds, D. Analytical method and apparatus therefor. 1999, International Patent Application No. WO99/13328.
    • (1999)
    • Hill, A.1    Bevan, C.2    Reynolds, D.3
  • 8
    • 0012865249 scopus 로고
    • Assessment of Distributon-pH Profiles
    • E: Pliska, V. Testa, B. Van de Waterbeemd, H. VCH (Weinhem)
    • Avdeef, A. Assessment of Distributon-pH Profiles, in Lipophilicity in Drug Action, E: Pliska, V. Testa, B. Van de Waterbeemd, H. VCH (Weinhem), 109, 1995.
    • (1995) Lipophilicity in Drug Action , vol.109
    • Avdeef, A.1
  • 9
    • 70350449594 scopus 로고    scopus 로고
    • Measurements of physical properties for drug design in industry
    • Separation Methods in Drug Synthesis and Purification, E: Smith, R.M. Elsevier (Amsterdam)
    • Valkó, K. Measurements of physical properties for drug design in industry, in Handbook of Analytical Separations, Volume 1. Separation Methods in Drug Synthesis and Purification, E: Smith, R.M. Elsevier (Amsterdam), 539, 2000.
    • (2000) Handbook of Analytical Separations , vol.1 , pp. 539
    • Valkó, K.1
  • 10
    • 0017112754 scopus 로고
    • Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography
    • Mirrlees, M.S., Moulton, S.J., Murphy, C.T., Taylor, P.J. Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography. J. Med. Chem. 19, 615, 1976.
    • (1976) J. Med. Chem. , vol.19 , pp. 615
    • Mirrlees, M.S.1    Moulton, S.J.2    Murphy, C.T.3    Taylor, P.J.4
  • 11
    • 0034720879 scopus 로고    scopus 로고
    • ElogP(oct): A tool for lipophilicity determination in drug discovery
    • Lombardo, F., Shalaeva, M.Y., Tupper, K A., Gao, F., Abraham, M.H. ElogP(oct): A tool for lipophilicity determination in drug discovery. J. Med. Chem. 43(15), 2922, 2000.
    • (2000) J. Med. Chem. , vol.43 , Issue.15 , pp. 2922
    • Lombardo, F.1    Shalaeva, M.Y.2    Tupper, K.A.3    Gao, F.4    Abraham, M.H.5
  • 14
    • 0034655372 scopus 로고    scopus 로고
    • A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates
    • Bevan, C.D., Lloyd, R.S. A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates. Anal. Chem. 72(8), 1781, 2000.
    • (2000) Anal. Chem. , vol.72 , Issue.8 , pp. 1781
    • Bevan, C.D.1    Lloyd, R.S.2
  • 15
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 46(1-3), 3, 2001.
    • (2001) Advanced Drug Delivery Reviews , vol.46 , Issue.1-3 , pp. 3
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 16
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high-throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
    • Kansy, M., Senner, F., Gubernator, K. Physicochemical high-throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes. J Med Chem. 41(7), 1007, 1998.
    • (1998) J. Med. Chem. , vol.41 , Issue.7 , pp. 1007
    • Kansy, M.1    Senner, F.2    Gubernator, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.