Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes

Diabetologia

Volumn 46, Issue 2, 2003, Pages 231-240

  Kawashima, J ^a   Tsuruzoe, K ^a   Motoshima, H ^a   Shirakami, A ^a   Sakai, K ^a   Hirashima, Y ^a   Toyonaga, T ^a   Araki, E ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

3T3 L1 cells; Cycloheximide; Insulin; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase; Resistin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOHEXIMIDE; DACTINOMYCIN; INSULIN; ISOENZYME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SUBUNIT; RESISTIN; RNA; SYNAPTOPHYSIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RNA SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0037299942     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-1022-3     Document Type: Article

References (34)

1. Saltiel AR (2000) The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. J Clin Invest 106:163-164
2. Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473-481
3. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
4. Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401:73-76
5. Yamauchi T, Kamon J, Waki H et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
6. Steppan CM, Bailey ST, Bhat S et al. (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312
7. Kim KH, Lee K, Moon YS, Sul HS (2001) A Cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276:11252-11256
8. Way JM, Görgün CZ, Tong Q et al. (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by PPARγ agonists. J Biol Chem 276:25651-25653
9. Savage DB, Sewter CP, Klenk ES et al. (2001) Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-γ action in humans. Diabetes 50:2199-2202
10. Engert JC, Vohl MC, Williams SM et al. (2002) 5′ flanking variants of resistin are associated with obesity. Diabetes 51:1629-1634
11. Nagaev I, Smith U (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 285:561-564
12. Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM (2002) Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res 10:1-5
13. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Isoproterenol inhibits resistin gene expression through a Gs-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Lett 500:60-63
14. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 288:1027-1031
15. O'Brien RH, Granner DK (1996) Regulation of gene expression by insulin. Physiol Rev 76:1109-1161
16. Haugen F, Jørgensen A, Drevon CH, Trayhurn P (2001) Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507:105-108
17. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM (1986) Adipocyte P2 gene: developmental expression and homology of 5′-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA 83:3786-3790
18. Simpson DA, Feeney S, Boyle C, Stitt AW (2000) Retinal VEGF mRNA measured by SYBR Green I fluorescence: A versatile approach to quantitative PCR. Mol Vis 6:178-183
19. Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K, Kahn CR (2001) Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling. Mol Cell Biol 21:26-38
20. Sakaue H, Ogawa W, Takata M et al. (1997) Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes. Mol Endocrinol 11:1552-1562
21. Rajala MW, Lin Y, Ranalletta M et al. (2002) Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-α in adipose tissue. Mol Endocrinol 16:1920-1930
22. Ribon V, Saltiel AR (1997) Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem J 324:839-846
23. Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR (1998) A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18:872-879
24. Baumann CA, Ribon V, Kanzaki M et al. (2000) CAP defines second signaling pathway required for insulin-stimulated glucose transport. Nature 407:202-207
25. Vaulont S, Kahn A (1994) Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J 8:28-35
26. Coffer PJ, Puijenbroek A van, Burgering BMT et al. (1997) Insulin activates Stat3 independently of p21ras-ERK and PI-3 K signal transduction. Oncogene 15:2529-2539
27. Pierreux CE, Ursø B, Meyts PD, Rousseau GG, Lemaigre FP (1998) Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Mol Endocrinol 12:1344-1354
28. De Los Pinos E, Fernandez De Mattos S, Joaquin M, Tauler A (2001) Insulin inhibits glucocorticoid-stimulated L-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression by activation of the c-Jun N-terminal kinase pathway. Biochem J 353:267-273
29. Balhoff JP, Stephens JM (1998) Highly specific and quantitative activation of STATs in 3T3-L1 adipocytes. Biochem Biophys Res Commun 247:894-900
30. Kayali AG, Austin DA, Webster NJ (2000) Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Diabetes 49:1783-1793
31. Sasaki K, Cripe TP, Koch SR et al. (1984) Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. J Biol Chem 259:15242-15251
32. Steppan CM, Brown EJ, Wright CM et al. (2001) A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 98:502-506
33. Shojima N, Sakoda H, Ogihara T et al. (2002) Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51:1737-1744
34. Zhande R, Mitchell JJ, Wu J, Sun XJ (2002) Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol 22:1016-1026