Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism

Biochemical Pharmacology

Volumn 65, Issue 3, 2003, Pages 339-348

  Yamada, Katsuhiko ^a,b   Arita, Kayo ^b,c   Kobuchi, Hirotsugu ^d   Yamamoto, Shinji ^a   Yoshioka, Tamotsu ^b   Tamai, Hiroshi ^a   Utsumi, Kozo ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b University of Tokyo   (Japan)

^c University of Tokyo   (Japan)

^d OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Akt; Apoptosis; Bid; Caspase; Cholesteryl hemisuccinate; Cytochrome c; HL 60 cells; Membrane permeability transition

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIUM ION; CASPASE 8; CHOLESTEROL HYDROGEN SUCCINATE; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; PLECKSTRIN; PROTEIN BAX; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER INHIBITION; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GRANULOCYTE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MITOSIS INHIBITION; MITOSIS RATE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CALCIUM; CARRIER PROTEINS; CASPASES; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CHOLESTEROL ESTERS; CYCLIC AMP; CYCLOSPORINE; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; MEMBRANE POTENTIALS; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0037298748     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01518-6     Document Type: Article

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