N4-(ω-aminoalkyl)-1-[(ω-aminoalkyl)amino]-4-acridinecarboxamides: Novel, potent, cytotoxic, and DNA-binding agents

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4801-4805

  Antonini, I ^a   Polucci, P ^a   Kelland, L R ^b   Spinelli, S ^c   Pescalli, N ^c   Martelli, S ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Novuspharma SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACRIDINECARBOXAMIDE DERIVATIVE; ACRIDINE DERIVATIVE; ALUMINUM; AMALGAM; AMIDE; AMINE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; N4 [2 (DIMETHYLAMINO)ETHYL] 1 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 4 ACRIDINECARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG DNA BINDING; DRUG POTENCY; FLUOROMETRY; HUMAN; HUMAN CELL; REDUCTION; TUMOR CELL LINE;

ACRIDINES; ANTINEOPLASTIC AGENTS; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROMETRY; HUMANS; INHIBITORY CONCENTRATION 50; TUMOR CELLS, CULTURED;

EID: 0034649655     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000131a     Document Type: Article

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