Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes

Archives of Toxicology

Volumn 77, Issue 2, 2003, Pages 110-115

  Oh, Seon Hee ^a   Yun, Ki Jung ^a   Nan, Ji Xing ^a,b   Sohn, Dong Hwan ^a   Lee, Byung Hoon ^a  

^a Wonkwang University   (South Korea)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Cholestasis; Cytoplasmic sequestration of p53

Indexed keywords

BILE SALT; CYTOCHROME C; MYC PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHOLESTASIS; CONTROLLED STUDY; ENZYME RELEASE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; LIVER CELL; LIVER MITOCHONDRION; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; RAT; WESTERN BLOTTING;

ANIMALIA;

EID: 0037292362     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0415-x     Document Type: Article

References (29)

1. Bennett M, MacDonald K, Chan SW, Luzio JP, Simari R, Weissberg P (1998) Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Science 282:290-293
2. Bissonnette RP, Echeverri F, Mahboubi A, Green DR (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359:552-554
3. El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B (1992) Definition of a consensus binding site for p53. Nat Genet 1:45-49
4. Faubion WA, Guicciardi ME, Miyoshi H, Bronk SF, Roverts PJ, Svingen PA, Kaufmann SH, Gores GJ (1999) Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 103:137-145
5. Funk WD, Pak DT, Kafas RH, Wright WE, Shay JW (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12:2866-2871
6. Galle PR, Hofmann WJ, Walczal H, Schaller H, Otto G, Stremmel W, Krammer PH, Punkel L (1995) Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182:1223-1230
7. Greim H, Trulzsch D, Roboz J, Dressler K, Czygan P, Hutterer F, Schaffner F, Popper H (1972) Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation. Gastroenterology 63:837-845
8. Gross A, Mcdonnell JM, Korsmeyer SJ (1999) Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
9. Han J, Sabbatini P, Perez D, Rao L, Modha D, White E (1996) The E1B 19 K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev 10:461-477
10. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95:4997-5002
11. Kountouras J, Billing BH, Scheuer PJ (1984) Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 65:305-311
12. Kurosawa H, Que FG, Roberts LR, Fesmier PJ, Gores GJ (1997) Hepatocytes in the bile duct-ligated rat express Bcl-2. Am J Physiol 272:G1587-G1593
13. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
14. Lieser MJ, Park JW, Natori S, Jones BA, Bronk SF, Gores GJ (1998) Cholestasis confers resistance to the rat liver mitochondrial permeability transition. Gastroenterology 115:693-701
15. Mckenzie PP, Guichard SM, Middlemas DS, Ashmun RA, Danks MK, Harris LC (1999) Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated. Clin Cancer Res 5:4199-4207
16. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
17. Miyoshi H, Rust C, Roberts PJ, Burgart LJ, Gores GJ (1999) Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas. Gastroenterology 117:669-677
18. Moll UT, Ostermeyer AG, Haladay R, Winkfield B, Frazier M, Zambetti G (1996) Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cellular Biol 16:1126-1137
19. Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A 95:14681-14686
20. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
21. Rodrigues CM, Fan G, Wong PY, Kren BT, Steer CJ (1998) Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 4:165-178
22. Rodrigues CM, Ma X, Linehan-Stieers C, Fan G, Kren BT, Steer CJ (1999) Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation. Cell Death Differ 6:842-854
23. Ryan JJ, Prochownik E, Gottlieb CA, Apel IJ, Merino R, Nunez G, Clarke MF (1994) c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci U S A 91:5878-5882
24. Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewsli S, Reed JC, Hoffman B, Liebermann D (1994) Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene 9:1791-1798
25. Shaulsky G, Goldfinger N, Tosky MS, Levine AJ, Rotter V (1991) Nuclear localization is essential for the activity of p53 protein. Oncogene 6:2055-2065
26. Sodeman T, Bronk SF, Roberts PJ, Miyoshi H, Gores GJ (2000) Bile salts mediated hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am J Physiol Gastrointest Liver Physiol 27:G992-G999
27. Stähelin BJ, Marti U, Zimmermann H, Reichen J (1999) The interaction of Bcl-2 and Bax regulates apoptosis in biliary epithelial cells of rats with obstructive jaundice. Virchows Arch 434:333-339
28. Thompson EB (1998) The many roles of c-Myc in apoptosis. Annu Rev Physiol 60:575-600
29. Xiang H, Kinoshita Y, Knudson CM, Korsmeyer SJ, Schwartzkroin PA, Morrison RS (1998) Bax involvement in p53-mediated neuronal cell death. J Neurosci 15:1363-1373