Somatic mutations and ageing in silico

Mechanisms of Ageing and Development

Volumn 124, Issue 1, 2003, Pages 85-92

  Kirkwood, Thomas B L ^a   Proctor, Carole J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Ageing; In silico; Mathematical model; Somatic mutations

Indexed keywords

AGING; CELL DIVISION; CELL POPULATION; COMPUTER MODEL; CONFERENCE PAPER; FIBROBLAST; GENOMICS; HUMAN; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0037289460     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(02)00177-X     Document Type: Conference Paper

References (43)

1. Bohr V.A. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radical Biology and Medicine. 32:2002;804-812.
2. Bürkle A. Physiology and pathophysiology of poly(ADP-ribosyl)ation. BioEssays. 23:2001;795-806.
3. Curtis H., Crowley C. Chromosome aberrations in liver cells in relation to the somatic mutation theory of aging. Radiation Research. 19:1963;337-344.
4. Dollé M.E.T., Giese H., Hopkins C.L., Martus H.J., Hausdorff J.M., Vijg J. Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nature Genetics. 17:1997;431-434.
5. Dollé M.E.T., Snyder W.K., Gossen J.A., Lohman P.H.M., Vijg J. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;8403-8408.
6. Francis A.A., Lee W.H., Regan J.D. The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals. Mechanisms of Ageing and Development. 16:1981;181-189.
7. Giese H., Dollé M.E.T., Hezel A., van Steeg H., Vijg J. Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA. Oncogene. 18:1999;1257-1260.
8. Gossen J.A., Deleeuw W.J.F., Verwest A., Lohman P.H.M., Vijg J. High somatic mutation frequencies in a lacz transgene integrated on the mouse X-chromosome. Mutation Research. 250:1991;423-429.
9. Grube K., Bürkle A. Poly(Adp-Ribose) Polymerase-activity in mononuclear leukocytes of 13 mammalian-species correlates with species-specific life-span. Proceedings of the National Academy of Sciences of the United States of America. 89:1992;11 759-11 763.
10. Hall K.Y., Hart R.W., Benirschke A.K., Walford R.L. Correlation between ultraviolet-induced DNA-repair in primate lymphocytes and fibroblasts and species maximum achievable life-span. Mechanisms of Ageing and Development. 24:1984;163-173.
11. Hanawalt P.C. DNA-repair comes of age. Mutation Research. 336:1995;101-113.
12. Hart R.W., Setlow R.B. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proceedings of the National Academy of Sciences of the United States of America. 71:1974;2169-2173.
13. Henshaw P.S., Riley E.F., Stapleton G.E. The biologic effects of pile radiation. Radiology. 49:1947;349-364.
14. Holliday R., Huschtscha L.I., Tarrant G.M., Kirkwood T.B.L. Testing the commitment theory of cellular aging. Science. 198:1977;366-372.
15. Holliday R., Kirkwood T.B.L. Predictions of the somatic mutation and mortalization theories of cellular aging are contrary to experimental-observations. Journal of Theoretical Biology. 93:1981;627-642.
16. Jones I.M., Thomas C.B., Tucker B., Thompson C.L., Pleshanov P., Vorobtsova I., Moore D.H. Impact of age and environment on somatic mutation at the Hprt gene of T-lymphocytes in humans. Mutation Research. 338:1995;129-139.
17. Kill I.R., Faragher R.G.A., Lawrence K., Shall S. The expression of proliferation-dependent antigens during the life-span of normal and progeroid human fibroblasts in culture. Journal of Cell Science. 107:1994;571-579.
18. Kirkwood T.B.L. Evolution of ageing. Nature. 270:1977;301-304.
19. Kirkwood T.B.L. Repair and its evolution: survival versus reproduction. Townsend C., Calow P. Physiological Ecology: An Evolutionary Approach to Resource Use. 1981;165-189 Blackwell Scientific Publications, Oxford.
20. Kirkwood, T.B.L., Boys, R.J., Gillespie, C.S., Proctor, C.J., Shanley, D.P., Wilkinson, D.J. 2003. Building models to unravel the complexity of ageing. Nature Reviews in Cell and Molecular Biology, in press.
21. Kirkwood T.B.L., Cremer T. Cytogerontology since 1881 - a reappraisal of August Weismann and a review of modern progress. Human Genetics. 60:1982;101-121.
22. Kirkwood T.B.L., Franceschi C. Is aging as complex as it would appear? Annals of the New York Academy of Sciences. 663:1992;412-417.
23. Kirkwood T.B.L., Holliday R. The evolution of ageing and longevity. Proceedings of the Royal Society London. 205:1979;531-546.
24. Kirkwood T.B.L., Kowald A. Network theory of ageing. Experimental Gerontology. 32:1997;395-399.
25. Kowald A., Kirkwood T.B.L. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutation Research. 316:1996;209-236.
26. Lindop P.J., Rotblat J. Shortening of life and causes of death in mice exposed to single whole-body dose of radiation. Nature. 189:1961;645-648.
27. Martin G.M., Ogburn C.E., Colgin L.M., Gown A.M., Edland S.D., Monnat R.J. Somatic mutations are frequent and increase with age in human kidney epithelial cells. Human Molecular Genetics. 5:1996;215-221.
28. Maynard Smith J. A theory of ageing. Nature. 184:1959;956-957.
29. Maynard Smith J. The causes of ageing. Proceedings of the Royal Society B. 157:1962;115-127.
30. Monckton D.G., Neumann R., Guram T., Fretwell N., Tamaki K., Macleod A., Jeffreys A.J. Minisatellite mutation-rate variation associated with a flanking DNA-sequence polymorphism. Nature Genetics. 8:1994;162-170.
31. Muiras M.L., Müller M., Schächter F., Bürkle A. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. Journal of Molecular Medicine. 76:1998;346-354.
32. Murray V. Are transposons a cause of aging? Mutation Research. 237:1990;59-63.
33. Nekrutenko A., Li W.H.S. Transposable elements are found in a large number of human protein-coding genes. Trends in Genetics. 17:2001;619-621.
34. Odagiri Y., Uchida H., Hosokawa M., Takemoto K., Morley A.A., Takeda T. Accelerated accumulation of somatic mutations in the senescence-accelerated mouse. Nature Genetics. 19:1998;116-117.
35. Ramsey M.J., Moore D.H., Briner J.F., Lee D.A., Olsen L.A., Senft J.R., Tucker J.D. The effects of age and life-style factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutation Research. 338:1995;95-106.
36. Smith J.R., Whitney R.G. Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. Science. 207:1980;82-84.
37. Sozou P.D., Kirkwood T.B.L. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. Journal of Theoretical Biology. 213:2001;573-586.
38. Szilard L. On the nature of the aging process. Proceedings of the National Academy of Sciences of the United States of America. 45:1959;35-45.
39. Thomas E., AlBaker E., Dropcova S., Denyer S., Ostad N., Lloyd A., Kill I.R., Faragher R.G.A. Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells. Experimental Cell Research. 236:1997;355-358.
40. Treton J.A., Courtois Y. Correlation between DNA excision repair and mammalian lifespan in lens epithelial-cells. Cell Biology International Reports. 6:1982;253-260.
41. Tucker J.D., Spruill M.D., Ramsey M.J., Director A.D., Nath J. Frequency of spontaneous chromosome aberrations in mice: effects of age. Mutation Research. 425:1999;135-141.
42. Vijg J. Somatic mutations and aging: a re-evaluation. Mutation Research. 447:2000;117-135.
43. von Zglinicki T. Oxidative stress shortens telomeres. Trends in Biochemical Sciences. 27:2002;339-344.