Increased glycolysis as protective adaptation of energy depleted, degenerating human hibernating myocardium

Molecular and Cellular Biochemistry

Volumn 242, Issue 1-2, 2003, Pages 101-107

  Vogt, Achim M ^c   Elsässer, Albrecht ^a   Nef, Holger ^a   Bode, Christoph ^a   Kübler, Wolfgang ^c   Schaper, Jutta ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; Energy metabolism; Glycolysis; Hibernating myocardium; Tissue degeneration

Indexed keywords

GLYCOGEN; LACTIC ACID;

ADAPTATION; ANAEROBIC GLYCOLYSIS; ANGIOCARDIOGRAPHY; ARTICLE; BIOCHEMISTRY; CELL DEGENERATION; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATION; ENERGY RESOURCE; ENERGY YIELD; GLYCOLYSIS; HEART FUNCTION; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART MUSCLE METABOLISM; HEART MUSCLE REVASCULARIZATION; HEART PROTECTION; HEART VENTRICULOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; METABOLITE; MORPHOLOGY; MYOCARDIAL HIBERNATION; OPEN HEART SURGERY; PATHOPHYSIOLOGY; PREOPERATIVE EVALUATION;

ADAPTATION, PHYSIOLOGICAL; APOPTOSIS; CYTOPROTECTION; ENERGY METABOLISM; GLYCOLYSIS; HEART; HEART CATHETERIZATION; HUMANS; IN SITU NICK-END LABELING; ISCHEMIA; MYOCARDIAL STUNNING; MYOCARDIUM;

EID: 0037283828     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021141812947     Document Type: Article

References (28)

1. Elsässer A, Schlepper M, Klovekorn WP, Cai WJ, Zimmermann R, Muller KD, Strasser R, Kostin S, Gagel C, Munkel B, Schaper W, Schaper J: Hibernating myocardium: an incomplete adaptation to ischemia. Circulation 96: 2920-2931, 1997
2. Elsässer A, Decker E, Kostin S, Hein S, Skwara W, Müller KD: A self-perpetuating vicious cycle of tissue damage in human hibernating myocardium. Mol Cell Biochem 213: 17-28, 2000
3. Elsässer A, Müller K, Skwara W, Bode C, Kübler W, Vogt A: Severe energy deprivation of human hibernating myocardium as possible pathomechanism of contractile dysfunction, structural degeneration and cell death. J Am Coll Cardiol 39: 1189-1198, 2002
4. Kao R, Rannels DE, Morgan HE: Effects of anoxia and ischemia on protein synthesis in perfused rat hearts. Circ Res 38: 1124-1130, 1976
5. Williams EH, Kao RL, Morgan HE: Protein degradation and synthesis during recovery from myocardial ischemia. Am J Physiol 240: E268-E273, 1981
6. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P: Intraccliular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 185: 1481-1486, 1997
7. Richter C, Schweizer M, Cossarizza A, Francheschi C: Control of apoptosis by the cellular ATP level. FEBS lett 378: 107-110, 1996
8. Eguchi Y, Shimizu S, Tsujimoto Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57: 1835-1840, 1997
9. Depre C, Taegtmeyer H: Metabolic aspects of programmed cell survival and cell death in the heart. Cardiovasc Res 45: 538-548, 2000
10. Nicotera P, Leist M, Ferrando-May E: Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol Lett 102-103: 139-142, 1998
11. Camici PG, Wijns W, Borgers M, De Silva R, Ferrari R, Knuuti J, Lammertsma AA, Liedtke AJ, Paternostro G, Vatner SF: Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (hibernating myocardium). Circulation 96:3205-3214, 1997
12. Brosius FC, Nguyen N, Egert S, Lin Z, Deeb GM, Haas F, Schwaiger M, Sun D: Increased sarcolernmal glucose transporter abundance in myocardial ischemia. Am J Cardiol 80: 77a-84a, 1997
13. Depre C, Vanoverschelde J-L, Taegtmeyer H: Glucose for the heart. Circulation 99: 578-588, 1999
14. King L, Opie L: Glucose and glycogen utilization in myocardial ischemia - changes in metabolism and consequences for the myocyte. Mol Cell Biochem. 180: 3-26, 1998
15. Elsässer A, Müller K, Vogt A, Strasser R, Gagel C, Schlepper M, Klövekorn W: Assessment of myocardial viability: Dobutamine echocardiography and thallium-201 single-photon emission computed tomographic imaging predict the postoperative improvement of left ventricular function after bypass surgery. Am Heart J 135: 463-475, 1998
16. Vogt AM, Ackermann C, Noe T, Jensen D, Kübler W: Simultaneous detection of high energy phosphates and metabolites of glycolysis and the Krebs cycle by HPLC. Biochem Biophys Res Commun 248: 527-532, 1998
17. Elsässer A, Schlepper M, Zimmermann R, Muller KD, Strasser R, Klovekorn WP, Schaper J: The extracellular matrix in hibernating myocardium - a significant factor causing structural defects and cardiac dysfunction. Mol Cell Biochem 186: 147-158, 1998
18. Lieberthal W, Menza SA, Levine JS: Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. Am J Physiol 274: F315-F327, 1998
19. Nagy PV, Feher T, Morga S, Matko J: Apoptosis of murine thymocytes induced by extracellular ATP is dose- and cytosolic pH-dependent. Immunol Lett 72: 23-30, 2000
20. Chow S, Kass G, Orrenius S: Purines and their roles in apoptosis. Neuropharmacology 36: 1149-1156, 1997
21. Uren NG, Camici PG: Hibernation and myocardial ischemia: clinical detection by positron emission tomography. Cardiovasc Drugs Ther 6: 273-279, 1992
22. Malthora R, Brosius FI: Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes. J Biol Chem 274:12567-12575, 1999
23. Jennings R, Reimer K: The cell biology of acute myocardial ischemia. Annu Rev Med 42: 225-246, 1991
24. Bing R: Coronary circulation and cardiac metabolism. In: A. Fishman, D. Richards (ed). Circulation of the Blood: Men and Ideals. Oxford University Press, New York, 1964
25. Bing R: The metabolism of the heart. In: Harvey Lecture Series. Academic Press, New York, 1954-55, pp 27-70
26. Vary T, Reibel D, Neely J: Control of energy metabolism in heart muscle. Ann Rev Physiol 43: 419-430, 1981
27. Neely J, Morgan H: Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol 16:411-459, 1974
28. Camici P, Dutka D: Repetitive stunning, hibernation, and heart failure: contribution of PET to establish a link. Am J Physiol 280: H929-H936, 2001