T cell autoreactivity by design: A theoretical framework for understanding tolerance, autoimmunity, and transplant rejection

Graft

Volumn 6, Issue 1, 2003, Pages 33-41

  Heeger, Peter S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Allograft rejection; Autoimmunity; Regulatory cells; T lymphocytes; Tolerance

Indexed keywords

ALLOGRAFT; ALLOIMMUNITY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; EXPERIMENTAL TRANSPLANTATION; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY; HOST CELL; IMMUNOLOGICAL PARAMETERS; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOREGULATION; ORGANOGENESIS; RECIPIENT; REVIEW; STANDARD; T LYMPHOCYTE; THEORETICAL MODEL; THYMUS;

EID: 0037276839     PISSN: 15221628     EISSN: None     Source Type: Journal    
DOI: 10.1177/1522162802239755     Document Type: Review

References (34)

1. Jameson SC, Hogquist KA, Bevan MJ. Positive selection of thymocytes. Annu Rev Immunol 1995;13:93.
2. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh, DY. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 1988;336:73.
3. Kisielow P, Teh HS, Bluthmann H, von Boehmer H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 1988;335:730.
4. von Boehmer H, Teh HS, Kisielow P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today 1989;10:57.
5. Targoni OS, Lehmann PV. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med 1998;187:2055.
6. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000;18:423.
7. Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002;3:756.
8. Burns JB, Bartholomew BD, Lobo ST. Isolation of CD45R0+, memory T cells recognizing proteolipid protein from neurologically normal subjects. Cell Immunol 2001;212:44.
9. Shevach EM. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389.
10. Anderson CC, Matzinger P. Immunity or tolerance: opposite outcomes of microchimerism from skin grafts. Nat Med 2001;7:80.
11. Fedoseyeva EV, Kishimoto K, Rolls HK, Illigens BM, Dong VM, Valujskikh A, et al. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants. J Immunol 2002;169:1168.
12. Heeger PS, Forsthuber T, Shive C, Biekert E, Genain C, Hofstetter HH, et al. Revisiting tolerance induced by autoantigen in incomplete Freund's adjuvant. J Immunol 2000;164:5771.
13. Cobbold S, Waldmann H. Infectious tolerance. Curr Opin Immunol 1998;10:518.
14. Zelenika D, Adams E, Humm S, Lin CY, Waldmann H, Cobbold SP. The role of CD4+ T-cell subsets in determining transplantation rejection or tolerance. Immunol Rev 2001;182:164.
15. Graca L, Cobbold SP, Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 2002;195:1641.
16. Fairchild PJ, Waldmann H. Dendritic cells and prospects for transplantation tolerance. Curr Opin Immunol 2000;12:528.
17. Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, Sparwasser T, et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 2002;17:211.
18. Lau HT, Yu M, Fontana A, Stoeckert CJ, Jr. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science 1996;273:109.
19. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998;281:1191.
20. Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 1998;4:1392.
21. Tian J, Lehmann PV, Kaufman DL. T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 1994;180:1979.
22. Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, et al. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 1998;281:703.
23. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1993;366:69.
24. Rolls HK, Kishimoto K, Illigens BM, Dong V, Sayegh MH, Benichou G, et al. Detection of cardiac myosin-specific autoimmunity in a model of chronic heart allograft rejection. Transplant Proc 2001;33:3821.
25. Fedoseyeva EV, Zhang F, Orr PL, Levin D, Buncke HJ, Benichou G. De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process. J Immunol 1999;162:6836.
26. Haque MA, Mizobuchi T, Yasufuku K, Fujisawa T, Brutkiewicz RR, Zheng Y, et al. Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. J Immunol 2002;169:1542.
27. Yasufuku K, Heidler KM, Woods KA, Smith GN, Jr., Cummings OW, Fujisawa T, et al. Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance. Transplantation 2002;73:500.
28. Yasufuku K, Heidler KM, O'Donnell PW, Smith GN, Jr., Cummings OW, Foresman BH, et al. Oral tolerance induction by type V collagen downregulates lung allograft rejection. Am J Respir Cell Mol Biol 2001;25:26.
29. Mares DC, Heidler KM, Smith GN, Cummings OW, Harris ER, Foresman B, et al. Type V collagen modulates alloantigen-induced pathology and immunology in the lung. Am J Respir Cell Mol Biol 2000;23:62.
30. Valujskikh A, Fedoseyeva F, Benichou G, Heeger PS. Development of autoimmunity after skin graft rejection via an indirect alloresponse. Transplantation 2002;73:1130.
31. Gould DS, Auchincloss H, Jr. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol Today 1999;20:77.
32. Green EA, Flavell RA. Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice. Immunol Rev 1999;169:11.
33. Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 2002;16:183.
34. Wildbaum G, Netzer N, Karin N. Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading. J Clin Invest 2002;110:701.