amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development

Genetics

Volumn 163, Issue 1, 2003, Pages 227-237

  Rayburn, Lowell Y M ^a   Gooding, Holly C ^a,c   Choksi, Semil P ^a,d   Maloney, Dhea ^a,e   Kidd III, Ambrose R ^a,f   Siekhaus, Daria E ^b,g   Bender, Michael ^a  

^a University of Georgia ^*  (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e Signature Bioscience Inc   (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID ETHYL ESTER; PROPROTEIN CONVERTASE 2; PROTEINASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME; DEVELOPMENTAL STAGE; DNA SEQUENCE; DROSOPHILA; EGG; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FEMALE; GENE IDENTIFICATION; GENE ISOLATION; GENE MUTATION; GENETIC CODE; GENETIC COMPLEMENTATION; GROWTH RETARDATION; HATCHING; HEAT SHOCK; HYPOTHESIS; LARVAL DEVELOPMENT; LETHALITY; MALE; MOLTING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DROSOPHILA; LARVA; MOLECULAR SEQUENCE DATA; MOLTING; POINT MUTATION; PROPROTEIN CONVERTASE 2; SUBTILISINS; TRANSGENES; WING;

ANIMALIA; HEXAPODA; MAMMALIA;

EID: 0037274656     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. ADAMS, M. D., S. E. CELNIKER, R. A. HOLT, C. A. EVANS, J. D. GOCAYNE et al., 2000 The genome sequence of Drosophila melanogaster. Science 287: 2185-2195.
2. ANDERSON, K.V., G. JURGENS and C. NUSSLEIN-VOLHARD, 1985 Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42: 779-789.
3. BENJANNET, S., N. RONDEAU, R. DAY, M. CHRETIEN and N. G. SEIDAH, 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl. Acad. Sci. USA 88: 3564-3568.
4. BERGERON, F., R. LEDUC and R. DAY, 2000 Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications. J. Mol. Endocrinol. 24: 1-22.
5. BRAR, B. K., and P. J. LOWRY, 1999 The differential processing of proenkephalin A in mouse and human breast tumour cell lines. J. Endocrinol. 161: 475-484.
6. BRYAN, P., M. W. PANTOLIANO, S. G. QUILL, H.-Y. HSIAO and T. POULOS, 1986 Site-directed mutagenesis and the role of the oxyanion hole in subtilisin. Proc. Natl. Acad. Sci. USA 83: 3743-3745.
7. CREEMERS, J. W., R. S. JACKSON and J. C. HUTTON, 1998 Molecular and cellular regulation of prohormone processing. Semin. Cell Dev. Biol. 9: 3-10.
8. EWER, J., S. C. GAMMIE and J. TRUMAN, 1997 Control of insect ecdysis by a positive-feedback endocrine system: roles of eclosion hormone and ecdysis triggering hormone. J. Exp. Biol. 200: 869-881.
9. FLYBASE, 2002 The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res. 30: 106-108.
10. FURUTA, M., H. YANO, A. ZHOU, Y. ROUILLE, J. J. HOLST et al., 1997 Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc. Natl. Acad. Sci. USA 94: 6646-6651.
11. FURUTA, M., R. CARROLL, S. MARTIN, H. H. SWIFT, M. RAVAZZOLA et al., 1998 Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J. Biol. Chem. 273: 3431-3437.
12. GAMMIE, S. C., and J. W. TRUMAN, 1997 Neuropeptide hierarchies and the activation of sequential motor behaviors in the hawkmoth, Manduca sexta. J. Neurosci. 17: 4389-4397.
13. GAROFALO, R. S., 2002 Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol. Metab. 13: 156-162.
14. HORODYSKI, F., 1996 Neuroendocrine control of insect ecdysis by eclosion hormone. J. Insect. Physiol. 42: 917-924.
15. HORODYSKI, F. M., J. EWER, L. M. RIDDIFORD and J. W. TRUMAN, 1993 Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster. Eur. J. Biochem. 215: 221-228.
16. HWANG, J. R., D. E. SIEKHAUS, R. S. FULLER, P. H. TAGHERT and I. LINDBERG, 2000 Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. J. Biol. Chem. 275: 17886-17893.
17. JIANG, N., A. S. KOLHEKAR, P. S. JACOBS, R. E. MAINS, B. A. EIPPER et al., 2000 PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Dev. Biol. 226: 118-136.
18. KIDD, A. R., III, D. TOLLA and M. BENDER, 1999 New lethal mutations in the 97B1-10 to 97D13 region of the Drosophila melanogaster 3rd chromosome. Dros. Inf. Serv. 82: 114-115.
19. LEWIS, E. B., and F. BACHER, 1968 Method of feeding ethyl methane sulfonate (EMS) to Drosophila males. Dros. Inf. Serv. 43: 193.
20. Li, T., and M. BENDER, 2000 A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila. Development 127: 2897-2905.
21. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, San Diego.
22. LIPKIND, G. M., A. ZHOU and D. F. STEINER, 1998 A model for the structure of the P domains in the subtilisin-like prohormone convertases. Proc. Natl. Acad. Sci. USA 95: 7310-7315.
23. LOI, P. K., S. A. EMMAL, Y. PARK and N.J. TUBLITZ, 2001 Identification, sequence and expression of a crustacean cardioactive peptide (CCAP) gene in the moth Manduca sexta. J. Exp. Biol. 204: 2803-2816.
24. MCNABB, S. L., J. D. BAKER, J. AGAPITE, H. STELLER, L. M. RIDDIFORD et al., 1997 Disruption of a behavioral sequence by targeted death of peptidergic neurons in Drosophila. Neuron 19: 813-823.
25. MESCE, K. A., and S. E. FAHRBACH, 2002 Integration of endocrine signals that regulate insect ecdysis. Front. Neuroendocrinol. 23: 179-199.
26. MULLER, L., and I. LINDBERG, 2000 The cell biology of the prohormone convertases PC1 and PC2. Progr. Nucleic Acid Res. Mol. Biol. 63: 69-108.
27. PARK, Y., D. ZITNAN, S. S. GILL and M. E. ADAMS, 1999 Molecular cloning and biological activity of ecdysis-triggering hormones in Drosophila melanogaster. FEBS Lett. 463: 133-138.
28. PARK, Y., V. FILIPPOV, S. S. GILL, and M. E. ADAMS, 2002 Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Development 129: 493-503.
29. RAYBURN, L. Y. M., S. P. CHOKSI and M. BENDER, 2002 Correction of an amontillado (amon) cDNA artifact and identification of single nucleotide polymorphisms in the amon gene. Dros. Inf. Serv. (in press).
30. ROCKWELL, N. C., G. T. WANG, G. A. KRAFFT and R. S. FULLER, 1997 Internally consistent libraries of fluorogenic substrates demonstrate that Kex2 protease specificity is generated by multiple mechanisms. Biochemistry 36: 1912-1917.
31. ROUILLE, Y., G. WESTERMARK, S. K. MARTIN and D. F. STEINER, 1994 Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells. Proc. Natl. Acad. Sci. USA 91: 3242-3246.
32. ROUILLE, Y., S. J. DUGUAY, K. LUND, M. FURUTA, Q. GONG et al., 1995a Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front. Neuroendocrinol. 16: 322-361.
33. ROUILLE, Y., S. MARTIN and D. F. STEINER, 1995b Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J. Biol. Chem. 270: 26488-26496.
34. RULIESON, E. J., S. K. KIM and R. NUSSE, 2002 Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296: 1118-1120.
35. SCHUBIGER, M., A. A. WADE, G. E. CARNEY, J. W. TRUMAN and M. BENDER, 1998 Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. Development 125: 2053-2062.
36. SEIDAH, N. G., S. BENJANNET, J. HAMELIN, A. M. MAMARBACHI, A. BASAK et al., 1999 The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Ann. NY Acad. Sci. 885: 57-74.
37. SHENNAN, K. I., S. P. SMEEKENS, D. F. STEINER and K. DOCHERTY, 1991 Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes. FEBS Lett. 284: 277-280.
38. SIEKHAUS, D. E., and R. S. FULLER, 1999 A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. J. Neurosci. 19: 6942-6954.
39. SIEZEN, R. J., and J. A. LEUNISSEN, 1997 Subtilases: the superfamily of subtilisin-like serine proteases. Protein Sci. 6: 501-523.
40. SMEEKENS, S. P., A. S. AVRUCH, J. LAMENDOLA, S. J. CHAN and D. F. STEINER, 1991 Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc. Natl. Acad. Sci. USA 88: 340-344.
41. SOSSIN, W. S., J. M. FISHER and R. H. SCHELLER, 1989 Cellular and molecular biology of neuropeptide processing and packaging. Neuron 2: 1407-1417.
42. STEINER, D. F., Y. ROUILLE, Q. GONG, S. MARTIN, R. CARROLL et al., 1996 The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals. Diabetes Metab. 22: 94-104.
43. YOSHIDA, H., S. OHAGI, T. SANKE, H. FURUTA, M. FURUTA et al., 1995 Association of the prohormone convertase 2 gene (PCSK2) on chromosome 20 with NIDDM in Japanese subjects. Diabetes 44: 389-393.
44. ZHOU, A., S. MARTIN, G. LIPKIND, J. LAMENDOLA and D. F. STEINER, 1998 Regulatory roles of the P domain of the subtilisin-like prohormone convertases. J. Biol. Chem. 273: 11107-11114.
45. ZHOU, A., G. WEBB, X. ZHU and D. F. STEINER, 1999 Proteolytic processing in the secretory pathway. J. Biol. Chem. 274: 20745-20748.
46. ZHU, X. I., Y. OHTA, F. JORDAN and M. INOUYE, 1989 Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process. Nature 339: 483-484.
47. ZITNAN, D., L. S. Ross, I. ZITNANOVA, J.J. HERMESMAN, S. S. GILL et al., 1999 Steroid induction of a peptide hormone gene leads to orchestration of a defined behavioral sequence. Neuron 23: 523-535.