Aberrant receptor-mediated Cushing's syndrome

Hormone Research

Volumn 59, Issue SUPPL. 1, 2003, Pages 99-103

  Bertagna, Xavier ^a   Groussin, Lionel ^a   Luton, Jean Pierre ^a   Bertherat, Jérôme ^a  

^a Hôpital Cochin ^*  (France)

Author keywords

Adrenal tumor; Cushing's syndrome; G protein coupled receptors

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CORTICOTROPIN; G PROTEIN COUPLED RECEPTOR; GASTRIC INHIBITORY POLYPEPTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN RECEPTOR; LUTEINIZING HORMONE; MEMBRANE RECEPTOR; RECEPTOR; VASOPRESSIN RECEPTOR;

ADRENAL CORTEX ADENOMA; ADRENAL HYPERPLASIA; CONFERENCE PAPER; CORRELATION ANALYSIS; CUSHING SYNDROME; ENDOCRINE TUMOR; HORMONE RESPONSE; HUMAN; HYDROCORTISONE RELEASE; HYPERCORTISOLISM; PRECURSOR; PREVALENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CUSHING SYNDROME; GASTRIC INHIBITORY POLYPEPTIDE; HUMANS; HYDROCORTISONE; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, CELL SURFACE; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, LH; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; RECEPTORS, VASOPRESSIN; VASOPRESSINS;

EID: 0037262001     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067832     Document Type: Conference Paper

References (20)

1. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L: GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989;340:692-696.
2. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G: Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 1993;365:649-651.
3. Waterman MR, Bischof LJ: Mechanisms of ACTH(cAMP)-dependent transcription of adrenal steroid hydroxylases. Endocr Res 1996;22:615-620.
4. Roger PP, Reuse S, Maenhaut C, Dumont JE: Multiple facets of the modulation of growth by cAMP. Vitam Horm 1995;51:59-191.
5. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM: Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991;325:1688-1695.
6. Hamet P, Larochelle P, Franks DJ, Cartier P, Bolte E: Cushing's syndrome with food-dependent periodic hormonogenesis. Clin Invest Med 1987;327:981-986.
7. Lacroix A, Bolte E, Tremblay J, Dupré J, Poitras P, Fournier H, Garon J, Garrel D, Bayard F, Taillefer R, et al.: Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's syndrome. N Engl J Med 1992;327:974-980.
8. Reznik Y, Allali-Zerah V, Chayvialle JA, Leroyer R, Leymarie P, Travert G, Lebrethon MC, Budi I, Ballière AM, Mahoudeau J: Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. N Engl J Med 1992;327:981-986.
9. Chabre O, Liakos P, Vivier J, Chaffanjon P, Labat-Moleur F, Martinie M, Bottari SP, Bachelot I, Chambaz EM, Defaye G, Feige JJ: Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. J Clin Endocrinol Metab 1998;83:3134-3143.
10. de Herder WW, Hofland LJ, Usdin TB, de Jong FH, Uitterlinden P, van Koetsveld P, Mezey E, Bonner TI, Bonjer HJ, Lamberts SW: Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells. J Clin Endocrinol Metab 1996;81:3168-3172.
11. Lebrethon MC, Avallet O, Reznick Y, Archambeaud F, Combes J, Usdin TB, Narboni G, Mahoudeau J, Saez JM: Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenal of three patients. J Clin Endocrinol Metab 1998;83:4514-4519.
12. Luton JP, Bertherat J, Kuhn JM, Bertagna X: Aberrant expression of the GIP (gastric inhibitory polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome (in French). Bull Acad Natl Med 1998;182:1839-1849;discussion 1849-1850.
13. N'Diaye N, Tremblay J, Hamet P, De Herder WW, Lacroix A: Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome. J Clin Endocrinol Metab 1998;83:2781-2785.
14. Lacroix A, Tremblay J, Rousseau G, Bouvier M, Hamet P: Propranolol therapy for ectopic beta-adrenergic receptors in adrenal Cushing's syndrome. N Engl J Med 1997;337:1429-1434.
15. Arnaldi G, Gasc JM, de Keyzer Y, Raffin-Sanson ML, Perraudin V, Kuhn JM, Raux-Demay MC, Luton JP, Clauser E, Bertagna X: Variable expression of the V1 vasopressin receptor modulates the phenotypic response of steroid-secreting adrenocortical tumors. J Clin Endocrinol Metab 1998;83:2029-2035.
16. Rilianawati, Paukku T, Kero J, Zhang FP, Rahman N, Kananen K, Huhtaniemi I: Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene. Mol Endocrinol 1998;12:801-809.
17. Lacroix A, N'Diaye N, Hamet P, Tremblay J, Boutin JM, Sairam MR: LH-Dependent Cushing's Syndrome (CS) in a Woman with Bilateral Macronodular Adrenal Hyperplasia: Control of Hypercortisolism with Leuprolide (abstract OR21-5). 80th Annual Meeting of the Endocrine Society, 1998, p. 80.
18. Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR: Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N Engl J Med 1998;339:27-31.
19. Mircescu H, Jilwan J, N'Diaye N, Bourdeau I, Tremblay J, Hamet P, Lacroix A: Are ectopic or abnormal membrane hormone receptors frequently present in adrenal Cushing's syndrome? J Clin Endocrinol Metab 2000;85:3531-3536.
20. Lacroix A, N'Diaye N, Tremblay J, Hamet P: Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocr Rev 2001;22:75-110.