Expression of DNA methyltransferases in multistep hepatocarcinogenesis

Human Pathology

Volumn 34, Issue 1, 2003, Pages 11-17

  Choi, Mi Sun ^a,b   Shim, Yhong hee ^a,b   Hwa, Jung Yong ^a,b   Lee, Seung Kyu ^a,b   Ro, Jae Y ^a,b   Kim, Jung sun ^a,b   Yu, Eunsil ^a,b  

^a University of Ulsan College of Medicine   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

DNA methyltransferase; Dysplastic nodule; Hepatocellular carcinoma; Hypermethylation

Indexed keywords

DNA METHYLTRANSFERASE; MESSENGER RNA;

ADVANCED CANCER; ARTICLE; CELL CYCLE; DYSPLASIA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; METHYLATION; PROTEIN EXPRESSION;

EID: 0037255729     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2003.5     Document Type: Article

References (36)

1. Singal R, Ginder GD: DNA methylation. Blood 93:4059-4070, 1999
2. Ehrlich M, Gama-Sosa MA, Huang LH: Amount and distribution of 5-methylcytosine in human DNA from different types of cells. Nucleic Acids Res 210:2709-2721, 1982
3. Bird AP: CpG-rich islands and the function of DNA methylation. Nature 321:209-213, 1986
4. Reik W, Kelsey G, Walter J: Dissecting de novo methylation. Nat Genet 23:380-382, 1999
5. Gama-Sosa MA, Slagel VA, Trewyn RW, et al: The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res 11:6883-6894, 1983
6. Baylin SB, Herman JG, Graff JR, et al: Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 72:141-196, 1998
7. Jones PA, Laird PW: Cancer epigenetics comes of age. Nat Genet 21:163-167, 1999
8. Momparler R, Bovenzi V: DNA methylation and cancer. J Cell Physiol 183:145-154, 2000
9. Shen JC, Rideout WM 3rd, Jones PA: High frequency mutagenesis by a DNA methyltransferase. Cell 71:1073-1080, 1992
10. Vachtenheim J, Horakova I, Novotna H: Hypomethylation of CCGG sites in the 3′ region of H-ras proto-oncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer. Cancer Res 54:1145-1148, 1994
11. Makos M, Nelkin BD, Reiter RE, et al: Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors. Cancer Res 53:2719-2722, 1993
12. Chen RZ, Pettersson U, Beard C, et al: DNA hypomethylation leads to elevated mutation rates. Nature 395:89-93, 1998
13. Leonhardt H, Page AW, Weier H, et al: A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71:865-873, 1992
14. Pradhan S, Bacolla A, Wells RD, et al: Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem 274:33002-33010, 1999
15. Robertson KD, Uzvolgyi E, Liang G, et al: The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27:2291-2298, 1999
16. Shay JW, Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cell Biol 33:787-791, 1997
17. Lei H, Oh SP, Okano M, et al: De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122:3195-3205, 1996
18. Yoder JA, Bestor TH: A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. Hum Mol Genet 7:279-284, 1998
19. Okano M, Xie S, Li E: Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltranses. Nat Genet 19:219-220, 1998
20. Xie S, Wang Z, Okano M, et al: Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236:87-95, 1999
21. Bird A: DNA methylation de novo. Science 286:2287-2288, 1999
22. Kautiainen TL, Jones PA: DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J Biol Chem 261: 1594-1598, 1986
23. Sun L, Hui AM, Kanai Y, et al: Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis. Jpn J Cancer Res 88:1165-1170, 1997
24. De Marzo AM, Marchi VL, Yang ES, et al: Abnormal regulation of DNA methyltransferase expressing during colorectal carcinogenesis. Cancer Res 59:3855-3860, 1999
25. Szyf M, Kaplan F, Mann V, et al: Cell cycle-dependent regulation of eukaryotic DNA metylase level. J Biol Chem 260:8653-8656, 1985
26. Szyf M, Bozovic V, Tanigawa G: Growth regulation of mouse DNA methyltranferase gene expression. J Biol Chem 266:10027-10030, 1991
27. Prem veer Reddy G, Pardee AB: Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A 77:3312-3316, 1980
28. Goto K, Numata M, Komura JI, et al: Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice. Differentiation 56:39-44, 1994
29. 1 to S phase transition in normal and tumor cells. Nucleic Acid Res 28:2108-2113, 2000
30. Chuang LS, Ian HI, Koh TW, et al: Human DNA-(cytosine 5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277:1996-2000, 1997
31. Eads CA, Danenberg KD, Kawakami K, et al: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltrasferase overexpression. Cancer Res 59:2320-2306, 1999
32. Saito Y, Kanai Y, Sakamoto M, et al: Expression of mRNA for DNA methyltrasferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33:561-568, 2001
33. International Working Party: Terminology of nodular hepatocellular lesions. Hepatology 22:983-993, 1995
34. Lin CH, Hsieh SY, Sheen IS, et al: Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 61:42384243, 2001
35. Patra SK, Patra A, Zhao H, et al: DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 33:163-171, 2002
36. Rhee I, Bachman KE, Park BH, et al: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416:552-556, 2002