Allosteric modulation of native cochlear P2X receptors: Insights from comparison with recombinant P2X2 receptors

Audiology and Neuro-Otology

Volumn 8, Issue 3, 2003, Pages 115-128

  Kanjhan, Refik ^a   Raybould, Nicholas P ^a   Jagger, Daniel J ^a   Greenwood, Denise ^a   Housley, Gary D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adenosine triphosphate gated ion channel; Allosteric modulation; Copper; Extracellular adenosine triphosphate; Hair cells; Hearing; pH; Zinc

Indexed keywords

ADENOSINE TRIPHOSPHATE; COPPER; COPPER ION; HYDROGEN; PROTON; PURINE P2X RECEPTOR; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; ZINC ION;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COCHLEA; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GUINEA PIG; MODULATION; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; REGULATORY MECHANISM; VOLTAGE CLAMP; XENOPUS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; COCHLEA; COPPER; DNA, COMPLEMENTARY; EXTRACELLULAR SPACE; FEMALE; GUINEA PIGS; HAIR CELLS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PROTONS; RECEPTORS, PURINERGIC P2; XENOPUS LAEVIS; ZINC;

EID: 0037247593     PISSN: 14203030     EISSN: None     Source Type: Journal    
DOI: 10.1159/000069478     Document Type: Article

References (72)

1. 4 receptor. J Neurochem 2000;74:1529-1537.
2. Ashmore JF, Ohmori H: Control of intracellular calcium by ATP in isolated outer hair cells of the guinea-pig cochlea. J Physiol 1990;428:109-131.
3. Bosher SK, Warren RS: Very low calcium content of cochlear endolymph, an extracellular fluid. Nature 1978;273:377-378.
4. Brake AJ, Wagenbach MJ, Julius D: New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 1994;371:519-523.
5. Brändle U, Zenner HP, Ruppersberg JP: Gene expression of P2X-receptors in the developing inner ear of the rat. Neurosci Lett 1999;273:105-108.
6. Burnstock G: Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 2001;22:182-188.
7. Chen C, Bobbin RP: P2X receptors in cochlear Deiters' cells. Br J Pharmacol 1998;124:337-344.
8. 4 purinoceptor removes extracellular pH sensitivity. J Physiol (Lond) 2000;523:697-703.
9. 2+ potentiates ATP-activated currents in rat sympathetic neurons. Pflugers Arch 1993;424:152-158.
10. 2+ ions. J Neurophysiol 1995;73:312-319.
11. Deng Y: Effect of gentamicin on the concentration of calcium, magnesium and zinc in perilymph of the guinea-pig. Zhonghua Er Bi Yan Hou Ke Za Zhi 1991;26:344-345.
12. 2 purinoceptors. J Gen Physiol 1999a;113:695-720.
13. (2) purinoceptors: Single channel recordings. J Membr Biol 1999b;172:215-223.
14. 2 purinoceptors by divalent cations. J Physiol 2000; 522;199-214.
15. 2+ signalling in Deiters' cells of the guinea-pig cochlea: Active process in supporting cells?; in Flock Å, Ottoson D, Ulfendahl M (eds): Active Hearing. Oxford, Pergamon, 1995, pp 195-207.
16. Edwards AF, Robertson SJ, Gibb AJ: Properties of ATP receptor-mediated synaptic transmission in the rat medial habenula. Neuropharmacology 1997;26:1253-1268.
17. Evans RJ, Lewis C, Virginio C, Lundstrom K, Buell G, Surprenant A, North RA: Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol (Lond) 1996;497:413-422.
18. Evans RJ, Surprenant A, North AR: P2X receptors: Cloned and expressed; in Turner JT, Weisman GA, Fedan JS (eds): The P2 Nucleotide Receptors. New Jersey, Humana Press, 1998, pp 43-62.
19. Fenwick EM, Marty A, Neher E: A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine. J Physiol (Lond) 1982;331:577-597.
20. Finkel AS, Gage PW: Conventional voltage clamping with two intracellular microelectrodes; in Smith TG, Lecar J, Redmann SJ, Gage PW (eds): Voltage and Patch Clamping with Microelectrodes. Baltimore, Williams & Wilkins, 1985.
21. i increases in cultured Purkinje neurons from neonatal rat cerebellum. Neuropharmacology 1999;38:699-706.
22. Gill SS, Salt AN: Quantitative differences in endolymphatic calcium and endocochlear potential between pigmented and albino guinea pigs. Hear Res 1997;113:191-197.
23. Glowatzki E: Analysis of gene expression in the organ of Corti revealed by single-cell RT-PCR. Audiol Neurootol 1997;2:71-78.
24. Goldin AL: Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol 1992;207: 266-279.
25. Goldin AL, Sumikawa K: Preparation of RNA for injection into Xenopus oocytes. Methods Enzymol 1992;207:279-297.
26. Hara A, Senarita M, Komeno M, Kusakari J: Metallic elements in the perilymph measured with an inductively-coupled plasma atomic emission spectrometer. Hear Res 1992;59:117-120.
27. Hara A, Komeno M, Senarita M, Serizawa F, Ishikawa T, Kusakari J: Effect of asphyxia on the composition of cationic elements in the perilymph. Hear Res 1995;90:228-231.
28. Housley GD, Greenwood D, Ashmore JF: Localization of cholinergic and purinergic receptors on outer hair cells isolated from the guinea-pig cochlea. Proc R Soc Lond B Biol Sci 1992;249:265-273.
29. 2 receptor subunit of the adenosine 5′-triphosphate-gated ion channel in the adult and developing rat inner ear by in situ hybridization. J Comp Neurol 1998;393:403-414.
30. 2 receptor subunit of the ATP-gated ion channel in the cochlea: Implications for sound transduction and auditory neurotransmission. J Neurosci 1999;19:8377-8388.
31. Housley GD: Nucleoside and nucleotide transmission in sensory systems; in Abbracchio MP, Williams M (eds): Purinergic and Pyrimidinergic Signalling. 1. Molecular, Nervous and Urogenitary System Function. Berlin, Springer, 2001, pp 339-369.
32. Housley GD, Jagger DJ, Greenwood D, Raybould NP, Salih SG, Järlebark LE, Vlajkovic SM, Kanjhan R, Nikolic P, Muñoz DJ, Thorne PR: Purinergic regulation of sound transduction and auditory neurotransmission. Audiol Neurootol 2002;7:55-61.
33. 2 receptor subunits in adult and developing rat cochlea. J Comp Neurol 2000;421:289-301.
34. 2 receptor subunits in the mouse cochlea. Neuroreport 2002;13:1979-1984.
35. Khakh BS: Molecular physiology of P2X receptors and ATP signalling at synapses. Nat Rev Neurosci 2001;2:165-174.
36. 2 purinoceptor to ATP revealed by changing extracellular pH. Br J Pharmacol 1996;117:1371-1373.
37. 2 receptor. Br J Pharmacol 1997;121:1445-1453.
38. King BF, Townsend-Nicholson A, Burnstock G: Metabotropic receptors for ATP and UTP: Exploring the correspondence between native and recombinant nucleotide receptors. Trends Pharmacol Sci 1998;19:506-514.
39. 6 subunits in Xenopus oocytes. J Neurosci 2000;20:4871-4877.
40. 2+ potentiates excitatory action of ATP on mammalian neurons. Proc Natl Acad Sci USA 1993;90:8264-8267.
41. Li C, Peoples RW, Weight FF: Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. Neuroreport 1996a;7:2151-2154.
42. 2+ in rat nodose ganglion neurons. J Neurophysiol 1996b;76:3048-3058.
43. 2+ potently enhances ATP-activated current in rat nodose ganglion neurons. Neurosci Lett 1996c;219:45-48.
44. Li C, Peoples RW, Weight FF: Enhancement of ATP-activated current by protons in dorsal root ganglion neurons. Pflugers Arch 1997a;433:446-454.
45. 2+ decreases the agonist affinity of the receptor. J Neurophysiol 1997b;77:3391-3395.
46. Li C, Peoples RW, Weight FF: Inhibition of ATP-activated current by zinc in dorsal root ganglion neurones of bullfrog. J Physiol 1997c;505:641-653.
47. Liu M, Dunn PM, King BF, Burnstock G: Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology. Br J Pharmacol 1999;128:61-68.
48. Mishrahy GA, Hildreth KM, Clark LC, Shinabarger EW: Measurement of the pH of the endolymph in the cochlea of guinea-pigs. Am J Physiol 1958;194:393-395.
49. Mockett BG, Housley GD, Thorne PR: Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells. J Neurosci 1994;14:6992-7007.
50. Muñoz DJ, Kendrick IS, Rassam M, Thorne PR: Vesicular storage of adenosine phosphate on the guinea-pig cochlear lateral wall and concentrations of ATP in the endolymph during sound exposure and hypoxia. Acta Otolaryngol 2001;121:10-15.
51. Nakagawa T, Akaike N, Kimitsuki T, Komune S, Arima T: ATP-induced current in isolated outer hair cells of guinea-pig cochlea. J Neurophysiol 1990;63:1068-1074.
52. Nakazawa K, Fujimori K, Takanaka A, Inoue K: An ATP-activated conductance in pheochromocytoma cells and its supression by extracellular calcium. J Physiol 1990;428:257-272.
53. Nakazawa K, Hess P: Block by calcium of ATP-activated channels in pheochromocytoma cells. J Gen Physiol 1993;101:377-392.
54. Nakazawa K., Ohno, Y: Effects of neuroamines and divalent cations on cloned and mutated ATP-gated channels. Eur J Pharmacol 1997;325:101-108.
55. 4 receptor channels expressed in human embryonic kidney cells. Neurosci Lett 2000;279:165-168.
56. 2 ATP receptor from the guinea-pig organ of Corti. Hear Res 1998;121:62-70.
57. Raybould NP, Housley GD: Variation in expression of the outer hair cell P2X receptor conductance along the guinea-pig cochlea. J Physiol 1997;498.3:717-727.
58. Salih SG, Jagger DJ, Housley GD: ATP-gated currents in rat primary auditory neurones in situ arise from a heteromultimetric P2X receptor subunit assembly. Neuropharmacology 2002;42:386-395.
59. Salt AN, Konishi T: The cochlear fluids: Perilymph and endolymph; in Altschuler RA, Hoffman DW, Bobbin RP (eds): Neurobiology of Hearing: The Cochlea. New York, Raven Press, 1986.
60. Stoop R, Surprenant A, North RA: Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. J Neurophysiol 1997;78:1837-1840.
61. Sugasawa M, Erostegui C, Blanchet C, Dulon D: ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea. J Physiol 1996;491:707-718.
62. Surprenant A, Buell G, North RA: P2X receptors bring new structure to ligand-gated ion channels. Trends Neurosci 1995;18:224-229.
63. Tomic M, Jobin RM, Vergara LA, Stojilkovic SS: Expression of purinergic receptor channels and their role in calcium signaling and hormone release in pituitary gonadotrophs. Integration of P2 channels in plasma membrane- and endoplasmic reticulum-derived calcium oscillations. J Biol Chem 1996;271:21200-21208.
64. Ueno T, Ueno S, Kakazu Y, Akaike N, Nabekura J: Bidirectional modulation of P2X receptor-mediated response by divalent cations in rat dorsal motor nucleus of the vagus neurons. J Neurochem 2001;78:1009-1018.
65. 7 receptor. Neuropharmacology 1997;36:1285-1294.
66. Wangemann P, Schacht J: Homeostatic mechanisms in the cochlea; in Dallos P, Popper AN, Fay RR (eds): The Cochlea. New York, Springer, 1996, pp 130-185.
67. 2 receptor by neurotransmitters and related substances. Br J Pharmacol 1997;120:221-224.
68. 2 receptors and its dependence on extracellular pH. Br J Pharmacol 1998;123:1214-1220.
69. 4 receptor function. J Neurophysiol 1999;81:2088-2094.
70. Zhong Y, Dunn PM, Xiang Z, Bo X, Burnstock G: Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br J Pharmacol 1998;125:771-781.
71. Zhong Y, Dunn PM, Burnstock G: Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons. Neuropharmacology 2000;39:172-180.
72. Zhong Y, Dunn PM, Burnstock G: Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. Br J Pharmacol 2001;132:221-233.