GABAergic nature of hypothalamic leptin target neurones in the ventromedial arcuate nucleus

Journal of Neuroendocrinology

Volumn 13, Issue 6, 2001, Pages 505-516

  Ovesjo M L ^a   Gamstedt, M ^a   Collin, M ^a   Meister, B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Body weight; Food intake; GAD; Leptin receptor; STAT3; VGAT

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; CARRIER PROTEIN; CYTOKINE; GLUTAMATE DECARBOXYLASE; HORMONE; ISOPROTEIN; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUROPEPTIDE Y; POLYCLONAL ANTIBODY; PROOPIOMELANOCORTIN; STAT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; VESICULAR 4 AMINOBUTYRIC ACID TRANSPORTER;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN NERVE CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GABAERGIC SYSTEM; GENETIC TRANSCRIPTION; HORMONE SYNTHESIS; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; MEDIATOR; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WEIGHT REDUCTION;

ANIMALS; ARCUATE NUCLEUS; CARRIER PROTEINS; DNA-BINDING PROTEINS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LEPTIN; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, OBESE; NEURONS; NEUROPEPTIDE Y; ORGANIC ANION TRANSPORTERS; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0034985554     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00662.x     Document Type: Article

References (73)

1. Positional cloning of the mouse obese gene and its human homologue
2. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
3. Weightreducing effects of the plasma protein encoded by the obese gene
4. Effects of the obese gene product on body weight regulation in oblob mice
5. Identification and expression cloning of a leptin receptor, OB-R
6. Abnormal splicing of the leptin receptor in diabetic mice
7. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
8. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
9. Defective stat signaling by the leptin receptor in diabetic mice
10. Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); Reduced expression of the rat fatty leptin receptor in transfected cells
11. STATs and gene regulation
12. Leptin activation in the hypothalamus of wild-type and oblob mice but not db/db mice
13. Leptin signaling in the hypothalamus of normal rats in vivo
14. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
15. Leptin treatment rescues the sterility of genetically obese ob/ob males
16. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus
17. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: Evidence for loss of its satiety effect in VMH-lesioned rats
18. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus- relationship with NPY neurones
19. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
20. Distributions of leptin receptor mRNA isoforms in the rat brain
21. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
22. Control of food intake via leptin receptors in the hypothalamus
23. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
24. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus
25. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
26. Heterogenity in the neuropeptide Y-containing neurons of the arcuate nucleus; GABAergic and non-GABAergic subpopulations
27. Transcription factors STAT3 in leptin target neurons of the rat hypothalamus
28. Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurones and glial cells
29. Ultrastructural immunolocalization of leptin receptor in mouse brain
30. Immunohistochemical localization of leptin receptor in the rat brain
31. Localization of leptin receptor immunoreactivity in the lean and the obese Zucker rat brain
32. Production and characterization of four anti-neuropeptide Y mouse monoclonal antibodies
33. Molecular cloning of rat leptin receptor isoform complementary DNAs: Identification of a missense mutation in Zucker fatty (falfa) rats
34. Down-regulated STAT3 messenger ribonucleic acid and STAT3 protein in the hypothalamic arcuate nucleus of the obese leptin-deficient (ob/ob) mouse
35. Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex
36. Distribution of the transcription factor signal transducer and activator of transcription 3 in the rat central nervous system and dorsal root ganglia
37. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions
38. Identification and characterization of the vesicular GABA transporter
39. Cloning and sequence analysis of murine cDNA encoding glutamate decarboxylase (GAD65)
40. Identification of the 62 kDa form of glutamic acid decarboxylase from the mouse
41. Sensitive mRNA detection using unfixed tissue: Combined radioactive and non-radioactive in situ hybridization histochemistry
42. GABA stimulation and blockade in the hypothalamus and midbrain: Effects on feeding and locomotor activity
43. The central GABAergic system and control of food intake under different experimental conditions
44. Stimulation of food intake by muscimol and β-endorphin
45. GABAergic and glycinergic mechanisms within the substantia nigra: Pharmacological specificity of dopamine-independent contralateral turning behavior and interactions with other neurotransmitters
46. GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol
47. Muscimol induced feeding: A model to study the hypothalamic regulation of appetite
48. GABA in the nucleus accumbens shell participates in the central regulation of feeding behaviour
49. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
50. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats
51. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
52. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
53. The role of neuropeptide Y in the antiobesity action of the obese gene product
54. Specificity of leptin action on elevated blood glucose and hypothalamic neuropeptide Y gene expression in ob/ob mice
55. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
56. Interactions between γ-aminobutyric acid in stimulation of feeding: A morphological and pharmacological analysis
57. Preproneuropeptide Y messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat is increased by food deprivation or dehydration
58. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase
59. Reduction of luteinizing hormone secretion induced by long-term feed restriction in male rats is associated with increased expression of GABA-synthesizing enzymes without alterations of GnRH gene expression
60. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
61. Central nervous system of food intake
62. Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary
63. GABAergic and catecholaminergic innervation of mediobasal hypothalamic beta-endorphin cells projecting to the medial preoptic area
64. Visualization of gamma-aminobutyric acid A receptors on proopimelanocortin-producing neurons in the rat hypothalamus
65. Regulation of α-melanocyte-stimulating hormone release from hypothalamic neurons
66. Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: A correlated light and electron microscopic double immunolabeling study
67. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
68. An arcuato-paraventricular and dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
69. The neuropeptide Y/agouti gene related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
70. Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA in the rat
71. Colocalization of neuropeptide Y immunoreactivity in brainstem cathecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
72. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice