Effects of vigabatrin on brain GABA+/Cr signals in focus-distant and focus-near brain regions monitored by 1H-NMR spectroscopy

European Journal of Neurology

Volumn 10, Issue 1, 2003, Pages 45-52

  Mueller, S G ^a   Weberb, O M ^b   Ducb, C O ^b   Meier, D ^b   Russ, W ^c   Boesiger, P ^b   Wieser, H G ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c Hoechst Marion Roussel Pharma AG   (Switzerland)

Author keywords

Epilepsy; Focus; GABA; Spectroscopy; Therapy; Vigabatrin

Indexed keywords

4 AMINOBUTYRIC ACID; VIGABATRIN;

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EPILEPSY; FEMALE; HEMISPHERE; HUMAN; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; BRAIN; CHROMIUM RADIOISOTOPES; EPILEPSY, COMPLEX PARTIAL; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC; VIGABATRIN;

EID: 0037238210     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2003.00506.x     Document Type: Article

References (47)

1. Babb TL, Pretorius JK, Kupfer WR, Feldblum S (1989). Recovery of decreased glutamate decarboxylase immunoreactivity after rat hippocampal kindling. Epilepsy Res 3:18-30.
2. Battistin L, Varotto M, Berlese G, Roman G (1984). Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities. Neurochem Res 9:225-231.
3. Behar KL, Rothman DL, Spencer DD, Petroff OA (1994). Analysis of macromolecule resonance in 1H NMR spectra of human brain. Magn Reson Med 32:294-302.
4. Cavalheiro EA, Fernandes MJ, Turski L, Naffah-Mazzacoratti MG (1994). Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus. Epilepsia 35:1-11.
5. De Felipe J (1999). Chandelier cells and epilepsy. Brain 122:1807-1822.
6. Ding R, Asada H, Obata K (1998). Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainaic acid. Brain Res 800:105-113.
7. Esclapez M, Houser CR (1999). Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy. J Comp Neurol 412:488-505.
8. Federico P, MacVicar BA (1996). Imaging the induction and spread of seizure activity in the isolated brain of the guinea pig: the roles of GABA and glutamate receptors. J Neurophysiol 76:3471-3492.
9. Gram L, Larsson OM, Johnson AH, Schousboue A (1988). Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons. Epilepsy Res 2:87-95.
10. Green RA, Metz A, Minchin MCW, Vincent ND (1987a). Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion. Br J Pharmac 92:5-11.
11. Green RA, Minchin MCW, Vincent ND (1987b). Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion. Br J Pharmac 92:13-18.
12. Green RA, Vincent ND (1987). The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. Br J Pharmac 92:19-24.
13. Higuchi T, Yamazaki O, Tazakawa A et al. (1986). Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdala-kindled rats. Eur J Pharmacol 125:169-175.
14. Hirsch JC, Agassandian C, Merchán-Pérez A et al. (1999). Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy. Nature Neuroscience 2:499-500.
15. Hoogland G, Hens JJH, De Wit M et al. (2000). Glutamate and γ-aminobutyric acid content and release of synaptosomes from temporal lobe epilepsy patients. J Neurosci Res 60:686-695.
16. Houser RC, Esclapez M (1996). Vulnerabilty and plasticity of the GABA-system in the pilocarpine model of spontaneous recurrant seizures. Epilepsy Res 26:207-218.
17. Kamphuis W, Gorter JA, Lopes da Silva F (1991). A long-lasting decrease in the inhibitory effect of GABA on glutamate responses of hippocampal pyramidal neurons induced by kindling epileptogenesis. Neuroscience 41:425-431.
18. Kapur J, Bennett JP, Wooten FG, Lothman EW (1989). Evidence for chronic loss of inhibition in the hippocampus after kindling: biochemical studies. Epilepsy Res 4:100-108.
19. Kuzniecky R, Ho S, Pan J et al. (2002). Modulation of cerebral GABA by topiramate, lamotrigine, and gabapentin in healthy adults. Neurology 58:368-372.
20. Lloyd KG, Bossi L, Morselli PL, Munari C, Rougier M, Loiseau H (1986). Alterations of GABA-mediated synaptic transmission in human epilepsy. Adv Neurol 44:1033-1044.
21. Löscher W, Schwark WS (1985). Evidence for impaired GABAergic activitiy in the substantia nigra of amygdaloid kindled rats. Brain Res 339:146-150.
22. Löscher W, Schwark WS (1987). Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain Res 420:385-390.
23. Lothman EW, Bennett JP, Perlin JB (1987). Alterations in neurotransmitter amino acids in hippocampal kindled seizures. Epilepsy Res 1:313-320.
24. Mathern GW, Mendoza D, Lozada A et al. (1999). Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology 52:453-472.
25. Meldrum BS (1989). GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br J Clin Pharmacol 27:3S-11S.
26. 1H-magnetic resonance spectroscopy study. Epilepsia. 39(Suppl. 2):S6.
27. Mueller SG, Weber OM, Duc CO et al. (2001). Effects of vigabatrin on brain GABA+/Cr signals in epileptics monitored by 1H-NMR-spectroscopy: responder characteristics. Epilepsia 42:29-40.
28. Nieuwenhuys R, Voogd J, van Huijzen C (1988). The Human Central Nervous System. A Synopsis and Atlas, 3rd revised edition. Springer, New York, pp. 367-372.
29. Obenaus A, Esclapez M, Houser CR (1993). Loss of glutamate decarboxylase mRNA-containig neurons in the rat dentate gyrus following pilocarpine-induced seizures. J Neuroscience 13:4470-4485.
30. Petroff OAC, Pleban LA, Spencer DD (1995a). Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetyl-aspartate, glutamate, and GABA content of the epileptic human brain. Magn Reson Imag 13:1197-1211.
31. 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate and glutamine in human brain. Epilepsia 36:457-464.
32. Petroff OAC, Rothman DL, Behar KL, Mattson RH (1996a). Low Brain GABA level is associated with poor seizure control. Ann Neurol 40:908-911.
33. Petroff OAC, Behar KL, Mattson RH, Rothman DL (1996b). Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. J Neurochem 67:2399-2404.
34. Petroff OA, Rothman DL, Behar KL, Lamoureux D, Mattson RH (1996c). The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann Neurol 39:95-99.
35. Petroff OAC, Mattson RH, Behar KL, Hyder F, Rothman DL (1998). Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol 44:948-952.
36. Petroff OAC, Rothman DL (1998). Measuring human brain GABA in vivo. Effects of GABA-transaminase inhibition with vigabatrin. Mol Neurobiol 16:97-121.
37. Piérard C, Pérès M, Satabin P, Guezenne CY, Lagarde D (1999). Effects of GABA-transaminase inhibition on brain metabolism and amino-acid compartmentation: an in vivo study by 2D/1H-NMR spectroscopy coupled with microdialysis. Exp Brain Res 127:321-327.
38. Rimvall K, Martin DL (1994). The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels. J Neurochem 62:1375-1381.
39. Rimvall K, Sheikh SN, Martin DL (1993). Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex. J Neurochem 60:714-720.
40. Rowley HL, Marsden CA, Martin KF (1995). Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo. Eur J Pharmacol 294:541-546.
41. Sloviter RS (1999). Status epilepticus-induced neuronal injury and network reorganization. Epilepsia 40(Suppl. 1):S34-S29.
42. Sloviter RS, Dichter MA, Rachinsky TL et al. (1996). Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J Comp Neurol 373:593-618.
43. Tasker JG, Dudek FE (1991). Electrophysiology of GABA-mediated synaptic transmission and possible roles in epilepsy. Neurochem Res 16:251-262.
44. Wasterlain CG, Baxter CF, Baldwin RA (1993). GABA metabolism in the substantia nigra, cortex and hippocampus during status epilepticus. Neurochem Res 18:527-532.
45. Weber OM, Trabesinger AH, Duc CO, Meier D, Boesiger P (1997). Detection of hidden metabolites by localized proton magnetic resonance spectroscopy in vivo. Technol Health Care 5:471-491.
46. Weber OM, Verhagen A, Duc CO, Meier D, Leenders KL, Boesiger P (1999). Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission topography. Magn Reson Imag 17:417-425.
47. Wilson CL, Babb TL, Halgren E, Crandall PH (1983). Visual receptive fields and response properties of neurons in human temporal lobe and visual pathways. Brain 106:473-502.