Lectins in drug delivery to the oral cavity, in vitro toxicity studies

S.T.P. Pharma Sciences

Volumn 13, Issue 1, 2003, Pages 37-40

  Smart, J D ^a   Banchonglikitkul, C ^b   Gibbs, R V ^a   Donovan, S J ^a   Cook, D J ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b Thailand Inst Scien/Technol Res   (Thailand)

Author keywords

Cell culture; Cytotoxicity; Helix pomatia; Lectins; Lycopersicon esculentum; Oral cavity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; LECTIN; PLANT EXTRACT;

ARTICLE; CELL LINE; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EXPOSURE; DRUG TARGETING; DRUG TOXICITY; HELIX POMATIA; HUMAN; HUMAN CELL; MOUTH CAVITY; NONHUMAN; POTATO; TOMATO; TREATMENT INDICATION; WHEAT;

EID: 0037229196     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. MAKELA O. - Studies in hæmagglutinins of leguminosæ seeds. - Ann. Med. Exp. Biol. Fenn., 35, Suppl. 11, 1957.
2. SHARON N. - Lectin-carbohydrate complexes of plants and animals: an atomic view. - TIBS, 18, 221-226, 1993.
3. KOMPELLA U.B., LEE V.H.L. - Means to enhance penetration. 4. Delivery systems for the enhancement of peptide and protein drugs: design considerations. - Adv. Drug. Deliv. Rev., 8, 115-162, 1992.
4. LEE J.W., PARK J.H., ROBINSON J.R. - Bioadhesive-based dosage forms: the next generation. - J. Pharm Sci., 89, 850-866, 2000.
5. LEHR C-M. - Lectin-mediated drug delivery: the second generation of bioadhesives. - J. Contr. Rel., 65, 19-29, 2000.
6. SHIER W.T. - Lectins as drug carriers. - In: Drug Carriers in Biology and Medicine, G. Gregoriadis Ed., Academic Press, London, 1979, pp. 43-70.
7. IRACHE J.M., DURRER C., DUCHENE D., PONCHEL G. - In vitro study of lectin-latex conjugates for specific bioadhesion. - J. Control. Rel., 31, 181-188, 1994.
8. LEHR C.-M., LEE V.H.L. - Binding and transport of some bioadhesive plant lectins across Caco-2 cell monolayer. - Pharm. Res., 10, 1796-1799, 1993.
9. NAISBETT B., WOODLEY J. - The potential for tomato lectin for oral drug delivery. 3. Bioadhesion in vivo. - Int. J. Pharm., 114, 227-236, 1995.
10. NANTWI P.K.K., COOK D.J., ROGERS D.J., SMART J.D. - Lectins for drug delivery within the oral cavity investigation of lectin binding to oral mucosa. - J. Drug Targeting, 5, 45-55, 1997.
11. BANCHONGLIKITKUL C., SMART J.D., GIBBS R.V., COOK D.J. - The binding of some Diocleæ lectins to the mucosal surfaces of the eye and mouth. - Brit. J. Biomed. Sci., 57, 7-12, 2000.
12. NICHOLLS T.J., GREEN K.L., COOK D.J., ROGERS D.J., WOLOWACZ S., SMART J.D. - Lectins in ocular drug delivery: an investigation of lectin binding sites on the corneal and conjunctival surfaces. - Int. J. Pharm., 138, 175-183, 1996.
13. NICHOLLS T.J., COOK D.J., ROGERS D.J., GREEN K.L., SMART J.D. - Lectins in ocular drug delivery. An in vivo study of lectin retention on ocular surfaces. - Pharmaceutical Sciences, 3, 1-5, 1997.
14. BANWELL J.G., BOLDT D.H., MEYERS J., WEBER F.L., MILLER B., HOWARD R. - Phytohæmagglutinin derived from red kidney bean (Phaseolus vulgaris): a cause for intestinal malabsorption associated with bacterial overgrowth in the rat. - Gastroenterology, 84, 506-515, 1983.
15. LIENER I.E. - Plant lectins, properties nutritional significance and function. - In: Antinutrients and Phytochemicals in Food, F. Shahidi Ed., ACS Symposium Series, American Chemical Society, Washington DC, 1997, pp. 31-44.
16. PUSTAI A., EWEN S.W.B., GRANT G., PEUMANS W.J., VAN DAMME E.J.M., COATES M.E., BARDOCZ S. - Lectins and also bacteria modify glycosylation of gut surface receptors in the rat. - Glycoconjugate Journal, 12, 22-35, 1995.
17. NAISBETT B., WOODLEY J. - The potential of tomato lectin for oral drug delivery. 4. Immunological consequences. - Int. J. Pharm., 120, 247-254, 1995.
18. LOREA P., GOLDSCHMIDT D., DARRO F., SALMON I., BOVIN N., GABIUS H.-J., KISS R., DANGUY A. - In vitro characterisation of lectin-induced alterations on the proliferative activity of three human melanoma cell lines. - Melanoma Res., 7, 353-363, 1997.
19. RIBEREAU-GAYON G., JUNG M.L., BECK J.P., ANTON R. Effect of fetal calf serum on the cytotoxic activity of Mistletoe (Viscum album L.) lectins in cell culture. - Phytotherapy Res., 9, 336-339, 1995.
20. FERREIRA R.R., CAVADA B.S., MOREIRA R.A., OLIVIERA J.T.A., GOMES J.C. - Characteristics of the histamine release from hamster cheek pouch mast cells stimulated by lectins from Brazilian beans and concanavalin A. - Inflamm. Res., 45, 442-447, 1996.
21. SMART J.D., NICHOLLS T.J., GREEN K.L., ROGERS D.J., COOK J.D. - Lectins in drug delivery: a study of the acute local irritancy of the lectins from Solanum tuberosum and Helix pomatia. - Europ. J. Pharm Sci., 9, 93-98, 1999.
22. SAARINEN-SAVOLAINEN P., JÄRVINEN T. ARAKI-SASAKI K., WATANABE H., URTTI A. - Evaluation of cytotoxicity of various ophthalmic drugs, eyedrop excipients and cyclodextrins in an immortalised human corneal epithelial cell line. - Pharm. Res., 15, 1275-1280, 1998.
23. MOCKEL B., SCHWARZ T., ZINKE H., ECK J., LANGER M., LENTZEN H. - Effects of Mistletoe lectin I on human blood cell lines and peripheral blood cells. - Drug Res., 47, 1145-1151, 1997.
24. KIM M., RAO V., TWEARDY D., PRAKASH M., GALILI U., GORELIK E. - Lectin-induced apoptosis of tumor cells. - Glycobiology, 3, 447-453, 1993.
25. KULKARNI G.V., McCULLOCH C.A.G. - Concanavalin A-induced apoptosis in fibroblasts: the role of cell surface carbohydrates in lectin mediated cytotoxicity.- J. Cell Physiol., 165, 119-133, 1995.