Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol in the drinking atypical ALDH2 genotype

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 1, 2000, Pages 1-7

  Takeshita, Tatsuya ^a   Morimoto, Kanehisa ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetaldehyde; Aldehyde Dehydrogenase; Drinking Behavior; Hemoglobin; Polymorphism

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; HEMOGLOBIN;

ALCOHOL CONSUMPTION; ARTICLE; BLOOD LEVEL; DNA POLYMORPHISM; DRINKING BEHAVIOR; GENOTYPE; HUMAN; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS;

EID: 0033963854     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb04545.x     Document Type: Article

References (56)

1. Agarwal DP, Goedde HW (1990) Alcohol Metabolism, Alcohol Intolerance, and Alcoholism. Springer-Verlag, Berlin.
2. Baraona E, Padova CD, Tabasco J, Lieber CS (1987) Red blood cells: A new major modality for acetaldehyde transport from liver to other tissues. Life Sci 40:253-258.
3. Enomoto N, Takase S, Yasuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141-144.
4. 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2′-deoxyguanosine-3′-monophosphate and DNA. Carcinogenesis 16: 2177-2185.
5. Fang J-L, Vaca CE (1997) Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis 18:627-632.
6. Fukunaga T, Sillanaukee P, Eriksson CJP (1993) Problems involved in the determination of endogenous acetaldehyde in human blood. Alcohol Alcohol 28:535-541.
7. Garro AJ, Lieber CS (1990) Alcohol and cancer. Annu Rev Pharmacol Toxicol 30:219-249.
8. 2 and ALDH2 genotypes in different populations. Hum Genet 88:344-346.
9. Goedde HW, Harada S, Agarwal DP (1979) Racial differences in alcohol sensitivity: A new hypothesis. Hum Genet 51:331-334.
10. Harada S, Agarwal DP, Goedde HW (1981) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet ii:982.
11. Hemminki K, Suni R (1984) Sites of reaction of glutaraldehyde and acetaldehyde with nucleosides. Arch Toxicol 55:186-190.
12. Higuchi S, Matsushita S, Muramatsu T, Hayashida M (1996) Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. Alcohol Clin Exp Res 20:493-497.
13. Hoerner M, Behrens UJ, Worner T, Lieber CS (1986) Humoral immune response to acetaldehyde adducts in alcoholic patients. Res Commun Chem Pathol Pharmacol 54:3-12.
14. Holman CD, English DR, Milne E, Winter MG (1996) Meta-analysis of alcohol and all-cause mortality: A validation of NHMRC recommendations. Med J Aust 164:141-145.
15. Hsu LC, Tani K, Fujiyoshi T, Kurachi K, Yoshida A (1985) Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. Proc Natl Acad Sci USA 82:3771-3775.
16. IARC (1985) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Allyl Compounds, Aldehydes, Epoxides and Peroxides. Vol. 36. International Agency for Research on Cancer, Lyon, France.
17. IARC (1988) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Alcohol Drinking. Vol. 44. International Agency for Research on Cancer, Lyon, France.
18. Lieber CS (1991a) Hepatic, metabolic and toxic effects of ethanol: 1991 update. Alcohol Clin Exp Res 15:573-592.
19. Lieber CS (1991b) Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. Plenum Press, New York.
20. Lin RC, Lumeng L, Shahidi S, Kelly T, Pound DC (1990) Protein-acetaldehyde adducts in serum of alcoholic patients. Alcohol Clin Exp Res 14:438-443.
21. Lin RC, Shahidi S, Kelly T, Lumeng C, Lumeng L (1993) Measurement of hemoglobin-acetaldehyde adduct in alcoholic patients. Alcohol Clin Exp Res 17:669-674.
22. Lucas D, Ménez JF, Bodénez P, Baccino E, Bardou LG, Floch HH (1988) Acetaldehyde adducts with haemoglobin: Determination of acetaldehyde released from haemoglobin by acid hydrolysis. Alcohol Alcohol 23:23-31.
23. Matsuda T, Kawanishi M, Yagi T, Matsui S, Takebe H (1998) Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases. Nucleic Acids Res 26:1769-1774.
24. Mauch TJ, Donohue TM, Zetterman RK, Sorrel MF, Tuma DJ (1986) Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes. Hepatology 6:263-269.
25. Mizoi Y, Yamamoto K, Ueno Y, Fukunaga T, Harada S (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29:707-710.
26. m aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ Health Perspect 104(Suppl 3):563-567.
27. Nakajima M, Takeuchi T, Takeshita T, Morimoto K (1996) 8-Hydroxydeoxyguanosine in human leukocyte DNA and daily health practice factors: Effects of individual alcohol sensitivity. Environ Health Perspect 104:1336-1338.
28. Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, Ichikawa Y, Suwaki H (1996) Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2: I. A comparison of the genotypes of ALDH2, ADH2, ADH3 and cytochrome P-4502E1 between alcoholics and non-alcoholics. Alcohol Clin Exp Res 20:52-55.
29. Niemelä O, Halmesmäki E, Ylikorkala O (1991) Hemoglobin-acetaldehyde adducts are elevated in women carrying alcohol-damaged fetuses. Alcohol Clin Exp Res 15:1007-1010.
30. Niemelä O, Israel Y (1992) Hemoglobin-acetaldehyde adducts in human alcohol abusers. Lab Invest 67:246-252.
31. Niemelä O, Israel Y, Fukunaga T, Eriksson CJP (1990) Hemoglobin-acetaldehyde adducts in human volunteers following acute ethanol ingestion. Alcohol Clin Exp Res 14:838-841.
32. Norppa H, Tursi F, Pfaffli P, Maki-Paakkanen J, Jarventaus H (1985) Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells. Cancer Res 45:4816-4821.
33. Peterson CM, Polizzi CM (1987) Improved method for acetaldehyde in plasma and hemoglobin-associated acetaldehyde: Results in teetotalers and alcoholics reporting for treatment. Alcohol 4:477-480.
34. Peterson CM, Ross SL, Scott BK (1990) Correlation of self-administered alcoholism screening test with hemoglobin-associated acetaldehyde. Alcohol 7:289-293.
35. Singh NP, Khan A (1995) Acetaldehyde: Genotoxicity and cytotoxicity in human lymphocytes. Mutat Res 337:9-17.
36. Sorrel MF, Tuma DJ (1987) The functional implications of acetaldehyde binding to cell constituents. Ann NY Acad Sci 492:50-62.
37. Leu(UUR) mutation at position 3243. Diabetes Care 19:1423-1425.
38. Takao A, Shimoda T, Kohno S, Asai S, Harada S (1998) Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype. J Allergy Clin Immunol 101:576-580.
39. m aldehyde dehydrogenase. Cancer Res 57:1241-1243.
40. Takeshita T, Mao XQ, Morimoto K (1996) The contribution of polymorphism in the alcohol dehydrogenase β-subunit to alcohol sensitivity in a Japanese population. Hum Genet 97:409-413.
41. m aldehyde dehydrogenase in Japanese workers. Lancet 341:837-838.
42. m aldehyde dehydrogenase in a Japanese population. Hum Genet 94:217-223.
43. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M (1996) High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology 23:234-239.
44. Thomasson HR, Edenberg HJ, Crabb DW, Mai X, Jerome RE, Li TK, Wang S, Lin Y, Lu R, Yin S (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681.
45. Tuma DJ, Newman MR, Donohue TM, Sorrell MF (1987) Covalent binding of acetaldehyde to proteins: Participation of lysine residues. Alcohol Clin Exp Res 11:579-584.
46. Vaca CE, Fang JL, Schweda EKH (1995) Studies of the reaction of acetaldehyde with deoxynucleosides. Chem Biol Interact 98:51-67.
47. Vasdev S, Whalen M, Ford CA, Longerich L, Prabhakaran V, Parai S (1995) Ethanol- and threonine-induced hypertension in rats: A common mechanism. Can J Cardiol 11:807-815.
48. Wickramasinghe SN, Gardner B, Barden G (1986) Cytotoxic protein molecules generated as a consequence of ethanol metabolism in vitro and in vivo. Lancet 2:823-826.
49. Wickramasinghe SN, Gardner B, Barden G (1987) Circulating cytotoxic protein generated after ethanol consumption: Identification and mechanism of reaction with cells. Lancet 2:122-126.
50. 14C-acetaldehyde with whole blood in vitro: Further evidence for the formation of unstable complexes with plasma proteins and red cells. Alcohol Alcohol 29:51-57.
51. Wolff PH (1972) Ethnic differences in alcohol sensitivity. Science 175:449-450.
52. Woutersen RA, Appelman LM, Van GHA, Feron VJ (1986) Inhalation toxicity of acetaldehyde in rats: III. Carcinogenicity study. Toxicology 41:213-231.
53. Xu Y, Carr L, Bosron WF, Li T-K, Edenberg HJ (1988) Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209-214.
54. Yamamoto K, Ueno Y, Mizoi Y, Tatsuno Y (1993) Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism. Arukoru Kenkyuto Yakubutsu Ison 28:13-25.
55. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H (1996a) Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 5:99-102.
56. Yokoyama A, Muramatsu T, Ohmori T, Makuuchi H, Higuchi S, Matsushita S, Yoshino K, Maruyama K, Nakano M, Ishii H (1996b) Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. Cancer 77:1986-1990.