First clinical experience with ADEPT

Advanced Drug Delivery Reviews

Volumn 22, Issue 3, 1996, Pages 365-367

  Bagshawe, K D ^a   Begent, R H J ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DISEASES; DRUG PRODUCTS; ENZYMES;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; IMMUNOSUPPRESSIVE AGENTS; MICE; MURINE MONOCLONAL ANTIBODY; TUMOUR;

DRUG THERAPY;

ANTIBODY; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIGEN; CYCLOSPORIN A; DIMETHYL SULFOXIDE; ENZYME; FLUOROURACIL; FOLINIC ACID; PRODRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTIBODY RESPONSE; BONE MARROW TOXICITY; CLINICAL TRIAL; COLON ADENOCARCINOMA; HUMAN; METASTASIS; NAUSEA; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; THROMBOCYTOPENIA; VOMITING;

EID: 0030589525     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00443-7     Document Type: Review

References (7)

1. [1] Bagshawe, K.D., Sharma, S.K., Springer, C.J. and Antoniw, P. (1995) Antibody directed enzyme prodrug therapy: a pilot-scale clinical trial. Tumor Target. 1, 17-29.
2. [2] Harwood, P.J., Britton, D.W., Southall, P.J. et al. (1986) Mapping epitome characteristics in carcinoembryonic antigen Br. J. Cancer 54, 75-82.
3. 131I distribution by gamma camera imaging. Eur. J. Nucl. Med. 16, 361-365.
4. [4] Sherwood, R.F., Melton, R.G., Alwan, S.M. and Hughes, P. (1985) Purification and properties of carboxypeptidase from Pseudomonas sp. strain Rs-16. Use of a novel triazine dye affinity method. Eur. J. Biochem. 148, 447-453.
5. [5] Sharma, S.K., Bagshawe, K.D., Burke, P.J. Boden, R.W. and Rogers, G.T. (1990) Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model. Br. J. Cancer 61, 659-662.
6. [6] Springer, C.J., Antoniw, P., Bagshawe, K.D., Searle, F., Bissett, G.M.F. and Jarman, M. (1990) Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J. Med. Chem. 33, 677-681.
7. [7] Sharma, S.K., Bagshawe, K.D., Melton, R.G. and Sherwood, R.F. (1993) Human immune response to monoclonal antibody enzyme conjugates in ADEPT. Cell Biophys. 21/22, 109-120.