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Volumn 8, Issue 4, 1997, Pages 510-519

Construction, expression, and activities of L49-sFv-β-lactamase, a single-chain antibody fusion protein for anticancer prodrug activation

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; ANTIBIOTICS; ANTIGENS; BLOOD; CHAINS; CHEMICAL ACTIVATION; CLONE CELLS; CLONING; ESCHERICHIA COLI; GENE ENCODING; POLYMERASE CHAIN REACTION; PURIFICATION; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TRANSCRIPTION; TUMORS;

EID: 0031194865     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc9700751     Document Type: Article
Times cited : (50)

References (45)
  • 2
    • 0345678344 scopus 로고
    • Design of anticancer prodrugs: Substrates for antibody targeted enzymes
    • Jungheim, L. N., and Shepherd, T. A. (1994) Design of anticancer prodrugs: substrates for antibody targeted enzymes. Chem. Rev. 94, 1553-1566.
    • (1994) Chem. Rev. , vol.94 , pp. 1553-1566
    • Jungheim, L.N.1    Shepherd, T.A.2
  • 3
    • 0028592664 scopus 로고
    • Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects
    • Bagshawe, K. D., Sharma, S. K., Springer, C. J., and Rogers, G. T. (1994) Antibody directed enzyme prodrug therapy (ADEPT). A review of some theoretical, experimental and clinical aspects. Ann. Oncol. 5, 879-891.
    • (1994) Ann. Oncol. , vol.5 , pp. 879-891
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Rogers, G.T.4
  • 4
    • 0028348376 scopus 로고
    • Tumor-selective prodrug activation by fusion protein-mediated catalysis
    • Bosslet, K., Czech, J., and Hoffmann, D. (1994) Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res. 54, 2151-2159.
    • (1994) Cancer Res. , vol.54 , pp. 2151-2159
    • Bosslet, K.1    Czech, J.2    Hoffmann, D.3
  • 5
    • 0028335819 scopus 로고
    • Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
    • Wallace, P. M., MacMaster, J. F., Smith, V., Kerr, D. E., Senter, P. D., and Cosand, W. L. (1994) Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res. 54, 2719-2723.
    • (1994) Cancer Res. , vol.54 , pp. 2719-2723
    • Wallace, P.M.1    MacMaster, J.F.2    Smith, V.3    Kerr, D.E.4    Senter, P.D.5    Cosand, W.L.6
  • 6
    • 0029019242 scopus 로고
    • In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates
    • Svensson, H. P., Vrudhula, V. M., Emswiler, J. E., MacMaster, J. F., Cosand, W. L., Senter, P. D., and Wallace, P. M. (1995) In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates. Cancer Res. 55, 2357-2365.
    • (1995) Cancer Res. , vol.55 , pp. 2357-2365
    • Svensson, H.P.1    Vrudhula, V.M.2    Emswiler, J.E.3    MacMaster, J.F.4    Cosand, W.L.5    Senter, P.D.6    Wallace, P.M.7
  • 8
    • 0027220125 scopus 로고
    • Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
    • Meyer, D. L., Jungheim, L. N., Law, K. L., Mikolajczyk, S. D., Shepherd, T. A., Mackensen, D. G., Briggs, S. L., and Starling, J. J. (1993) Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res. 53, 3956-3963.
    • (1993) Cancer Res. , vol.53 , pp. 3956-3963
    • Meyer, D.L.1    Jungheim, L.N.2    Law, K.L.3    Mikolajczyk, S.D.4    Shepherd, T.A.5    Mackensen, D.G.6    Briggs, S.L.7    Starling, J.J.8
  • 9
    • 0027942213 scopus 로고
    • Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185
    • Eccles, S. A., Court, W. J., Box, G. A., Dean, C. J., Melton, R. G., and Springer, C. J. (1994) Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185. Cancer Res. 54, 5171-5177.
    • (1994) Cancer Res. , vol.54 , pp. 5171-5177
    • Eccles, S.A.1    Court, W.J.2    Box, G.A.3    Dean, C.J.4    Melton, R.G.5    Springer, C.J.6
  • 10
    • 0029095503 scopus 로고
    • Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs
    • Kerr, D. E., Schreiber, G. L., Vrudhula, V. M., Svensson, H. P., Hellström, I., Hellström, K. E., and Senter, P. D. (1995) Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs. Cancer Res. 55, 3558-3563.
    • (1995) Cancer Res. , vol.55 , pp. 3558-3563
    • Kerr, D.E.1    Schreiber, G.L.2    Vrudhula, V.M.3    Svensson, H.P.4    Hellström, I.5    Hellström, K.E.6    Senter, P.D.7
  • 12
    • 0019493358 scopus 로고
    • Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies
    • Brown, J. P., Nishiyama, K., Hellström, I., and Hellström, K. E. (1981) Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies. J. Immunol. 127, 539-545.
    • (1981) J. Immunol. , vol.127 , pp. 539-545
    • Brown, J.P.1    Nishiyama, K.2    Hellström, I.3    Hellström, K.E.4
  • 14
    • 0008144817 scopus 로고
    • Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence
    • Rose, T. M., Plowman, G. D., Teplow, D. B., Dreyer, W. J., Hellström, K. E., and Brown, J. P. (1986) Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. Proc. Natl. Acad. Sci. U.S.A. 83, 1261-1265.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 1261-1265
    • Rose, T.M.1    Plowman, G.D.2    Teplow, D.B.3    Dreyer, W.J.4    Hellström, K.E.5    Brown, J.P.6
  • 15
    • 0028535272 scopus 로고
    • High yield, site-specific coupling of N-terminally modified β-lactamase to a proteolytically derived single-sulfhydryl murine Fab′
    • Mikolajczyk, S. D., Meyer, D. L., Starling, J. J., Law, K. L., Rose, K., Dufour, B., and Offord, R. E. (1994) High yield, site-specific coupling of N-terminally modified β-lactamase to a proteolytically derived single-sulfhydryl murine Fab′. Bioconjugate Chem. 5, 636-646.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 636-646
    • Mikolajczyk, S.D.1    Meyer, D.L.2    Starling, J.J.3    Law, K.L.4    Rose, K.5    Dufour, B.6    Offord, R.E.7
  • 18
    • 0026569992 scopus 로고
    • Molecular and functional characterization of a fusion protein suited for tumor specific prodrug activation
    • Bosslet, K., Czech, J., Lorenz, P., Sedlacek, H. H., Shuermann, M., and Seemann, G. (1992) Molecular and functional characterization of a fusion protein suited for tumor specific prodrug activation. Br. J. Cancer 65, 234-238.
    • (1992) Br. J. Cancer , vol.65 , pp. 234-238
    • Bosslet, K.1    Czech, J.2    Lorenz, P.3    Sedlacek, H.H.4    Shuermann, M.5    Seemann, G.6
  • 19
    • 0027157591 scopus 로고
    • Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to β-lactamase
    • Goshorn, S. C., Svensson, H. P., Kerr, D. E., Somerville, J. E., Senter, P. D., and Fell, H. P. (1993) Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to β-lactamase. Cancer Res. 53, 2123-2127.
    • (1993) Cancer Res. , vol.53 , pp. 2123-2127
    • Goshorn, S.C.1    Svensson, H.P.2    Kerr, D.E.3    Somerville, J.E.4    Senter, P.D.5    Fell, H.P.6
  • 20
    • 0028959129 scopus 로고
    • Development of a humanized disulfide-stabilized anti-p185 HER2 Fv-β-lactamase fusion protein protein for activation of a cephalosporin doxorubicin prodrug
    • Rodrigues, M. L., Presta, L. G., Kotts, C. F., Wirth, C., Mordenti, J., Osaka, G., Wong, W. L. T., Nuijens, A., Blackburn, B., and Carter, P. (1995) Development of a humanized disulfide-stabilized anti-p185 HER2 Fv-β-lactamase fusion protein protein for activation of a cephalosporin doxorubicin prodrug. Cancer Res. 55, 63-70.
    • (1995) Cancer Res. , vol.55 , pp. 63-70
    • Rodrigues, M.L.1    Presta, L.G.2    Kotts, C.F.3    Wirth, C.4    Mordenti, J.5    Osaka, G.6    Wong, W.L.T.7    Nuijens, A.8    Blackburn, B.9    Carter, P.10
  • 21
    • 0024287069 scopus 로고
    • Sequence and comparative analysis of three Enterobacter cloacae ampC beta-lactamase genes and their products
    • Galleni, M., Lindberg, F., Normark, S., Cole, S., Honore, N., Joris, B., and Frère, J. M. (1988) Sequence and comparative analysis of three Enterobacter cloacae ampC beta-lactamase genes and their products. Biochem. J. 250, 753-760.
    • (1988) Biochem. J. , vol.250 , pp. 753-760
    • Galleni, M.1    Lindberg, F.2    Normark, S.3    Cole, S.4    Honore, N.5    Joris, B.6    Frère, J.M.7
  • 22
    • 0030044332 scopus 로고    scopus 로고
    • Modifying the specificity and activity of the Enterobacter cloacae P99 β-lactamase by mutagenesis within an M13 phage vector
    • Siemers, N. O., Yelton, D. E., Bajorath, J., and Senter, P. D. (1996) Modifying the specificity and activity of the Enterobacter cloacae P99 β-lactamase by mutagenesis within an M13 phage vector. Biochemistry 35, 2104-2111.
    • (1996) Biochemistry , vol.35 , pp. 2104-2111
    • Siemers, N.O.1    Yelton, D.E.2    Bajorath, J.3    Senter, P.D.4
  • 23
    • 0028425474 scopus 로고
    • Synthesis and characterization of monoclonal antibody-β-lactamase conjugates
    • Svensson, H. P., Wallace, P. M., and Senter, P. D. (1994) Synthesis and characterization of monoclonal antibody-β-lactamase conjugates. Bioconjugate Chem. 5, 262-267.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 262-267
    • Svensson, H.P.1    Wallace, P.M.2    Senter, P.D.3
  • 24
    • 0027655158 scopus 로고
    • Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates
    • Vrudhula, V. M., Svensson, H. P., Kennedy, K. A., Senter, P. D., and Wallace, P. M. (1993) Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Bioconjugate Chem. 4, 334-340.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 334-340
    • Vrudhula, V.M.1    Svensson, H.P.2    Kennedy, K.A.3    Senter, P.D.4    Wallace, P.M.5
  • 25
    • 37049167654 scopus 로고
    • Aryl-2-halo-genoalkylamines. Part II
    • Everett, J. L., and Ross, W. C. R. (1949) Aryl-2-halo-genoalkylamines. Part II. J. Chem. Soc., 1972-1983.
    • (1949) J. Chem. Soc. , pp. 1972-1983
    • Everett, J.L.1    Ross, W.C.R.2
  • 27
    • 0342373035 scopus 로고
    • Determination of equilibrium binding parameters of monoclonal antibodies specific for cell surface antigens
    • (I. Lefkovits and B. Pernis, Eds.) Academic Press, New York
    • Trucco, M., and dePetris, S. (1981) Determination of equilibrium binding parameters of monoclonal antibodies specific for cell surface antigens. Immunological Methods (I. Lefkovits and B. Pernis, Eds.) pp 1-26, Academic Press, New York.
    • (1981) Immunological Methods , pp. 1-26
    • Trucco, M.1    DePetris, S.2
  • 28
    • 0027312095 scopus 로고
    • Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): Apical compartmentalization in intestinal epithelial cells
    • Alemany, R., Rosa Vila, M., Franci, C., Egea, G., Real, R. X., and Thomson, T. M. (1993) Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells. J. Cell Sci. 104, 1155-1162.
    • (1993) J. Cell Sci. , vol.104 , pp. 1155-1162
    • Alemany, R.1    Rosa Vila, M.2    Franci, C.3    Egea, G.4    Real, R.X.5    Thomson, T.M.6
  • 29
    • 0028111120 scopus 로고
    • Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein
    • Food, M. R., Rothenberger, S., Gabathuler, R., Haidl, I. D., Reid, G., and Jefferies, W. A. (1994) Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. J. Biol. Chem. 269, 3034-3040.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3034-3040
    • Food, M.R.1    Rothenberger, S.2    Gabathuler, R.3    Haidl, I.D.4    Reid, G.5    Jefferies, W.A.6
  • 30
    • 11944265249 scopus 로고
    • High level expression of tissue inhibitor of metallo-proteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification
    • Cockett, M. I., Bebbington, C. R., and Yarranton, G. I. (1990) High level expression of tissue inhibitor of metallo-proteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. Biotechnology 8, 662-667.
    • (1990) Biotechnology , vol.8 , pp. 662-667
    • Cockett, M.I.1    Bebbington, C.R.2    Yarranton, G.I.3
  • 31
    • 0024445907 scopus 로고
    • The construction of a highly efficient and versatile set of mammalian expression vectors
    • Stephens, P. E., and Cockett, M. I. (1989) The construction of a highly efficient and versatile set of mammalian expression vectors. Nucleic Acids Res. 17, 7110.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 7110
    • Stephens, P.E.1    Cockett, M.I.2
  • 33
    • 0026084577 scopus 로고
    • Rapid PCR-cloning of full-length mouse immunoglobulin variable regions
    • Jones, S. T., and Bendig, M. M. (1991) Rapid PCR-cloning of full-length mouse immunoglobulin variable regions. Biotechnology 9, 88-92.
    • (1991) Biotechnology , vol.9 , pp. 88-92
    • Jones, S.T.1    Bendig, M.M.2
  • 35
    • 0021763813 scopus 로고
    • Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose
    • Cartwright, S. J., and Waley, S. G. (1984) Purification of β-lactamases by affinity chromatography on phenylboronic acid-agarose. Biochem. J. 221, 505-512.
    • (1984) Biochem. J. , vol.221 , pp. 505-512
    • Cartwright, S.J.1    Waley, S.G.2
  • 36
    • 0026826545 scopus 로고
    • Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug
    • Svensson, H. P., Kadow, J. F., Vrudhula, V. M., Wallace, P. M., and Senter, P. D. (1992) Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug. Bioconjugate Chem. 3, 176-181.
    • (1992) Bioconjugate Chem. , vol.3 , pp. 176-181
    • Svensson, H.P.1    Kadow, J.F.2    Vrudhula, V.M.3    Wallace, P.M.4    Senter, P.D.5
  • 37
    • 0015327122 scopus 로고
    • Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate
    • O'Callaghan, D. E., Morris, A., Kirby, S., and Shingler, A. H. (1972) Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob. Agents Chemother. 1, 283-288.
    • (1972) Antimicrob. Agents Chemother. , vol.1 , pp. 283-288
    • O'Callaghan, D.E.1    Morris, A.2    Kirby, S.3    Shingler, A.H.4
  • 38
    • 0027008593 scopus 로고
    • Mono- and bivalent antibody fragments produced in E. coli: Engineering, folding, and antigen binding
    • Plückthun, A. (1992) Mono-and bivalent antibody fragments produced in E. coli: engineering, folding, and antigen binding. Immunol. Rev. 130, 151-188.
    • (1992) Immunol. Rev. , vol.130 , pp. 151-188
    • Plückthun, A.1
  • 39
    • 0030198347 scopus 로고    scopus 로고
    • Characterization of protein-hapten conjugates. 2. Electro-spray mass spectrometry of bovine serum albumin-hapten conjugates
    • Adamczyk, M., Gebler, J. C., and Mattingly, P. G. (1996) Characterization of protein-hapten conjugates. 2. Electro-spray mass spectrometry of bovine serum albumin-hapten conjugates. Bioconjugate Chem. 7, 475-481.
    • (1996) Bioconjugate Chem. , vol.7 , pp. 475-481
    • Adamczyk, M.1    Gebler, J.C.2    Mattingly, P.G.3
  • 41
    • 0028518514 scopus 로고
    • A designed peptide ligase for total synthesis of ribonuclease a with unnatural catalytic residues
    • Jackson, D. Y., Burnier, J., Quan, C., Stanley, M., Tom, J., and Wells, J. A. (1994) A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. Science 266, 243-247.
    • (1994) Science , vol.266 , pp. 243-247
    • Jackson, D.Y.1    Burnier, J.2    Quan, C.3    Stanley, M.4    Tom, J.5    Wells, J.A.6
  • 44
    • 0027656118 scopus 로고
    • Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of a cytosine deaminase immunoconjugate
    • Kerr, D. E., Garrigues, U. S., Wallace, P. M., Hellström, K. E., Hellström, I., and Senter, P. D. (1993) Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of a cytosine deaminase immunoconjugate. Bioconjugate Chem. 4, 353-357.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 353-357
    • Kerr, D.E.1    Garrigues, U.S.2    Wallace, P.M.3    Hellström, K.E.4    Hellström, I.5    Senter, P.D.6
  • 45
    • 0029416920 scopus 로고
    • Plasma clearance of an antibody-enzyme conjugate in ADEPT by monoclonal anti-enzyme: Its effect on prodrug activation in vivo
    • Rogers, G. T., Burke, P. J., Sharma, S. K., Koodie, R., and Boden, J. A. (1995) Plasma clearance of an antibody-enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo. Br. J. Cancer 72, 1357-1363.
    • (1995) Br. J. Cancer , vol.72 , pp. 1357-1363
    • Rogers, G.T.1    Burke, P.J.2    Sharma, S.K.3    Koodie, R.4    Boden, J.A.5


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