Theoretical analysis of conjugate localization in two-step cancer chemotherapy

Journal of Mathematical Biology

Volumn 39, Issue 4, 1999, Pages 353-376

  Jackson, Trachette L ^a   Lubkin, Sharon R ^b   Murray, James D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA LACTAMASE; HYBRID PROTEIN; MONOCLONAL ANTIBODY; PRODRUG;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPARATIVE STUDY; COMPUTER SIMULATION; HUMAN; MATHEMATICAL COMPUTING; MELANOMA; METABOLISM; MOUSE; NUDE MOUSE; SKIN TUMOR; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BETA-LACTAMASES; COMPUTER SIMULATION; HUMANS; MELANOMA; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PRODRUGS; RECOMBINANT FUSION PROTEINS; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033211146     PISSN: 03036812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002850050195     Document Type: Article

References (24)

1. Bagshawe, K. and Begent, R. (1996). First clinical experience with ADEPT. Adv. Drug Delivery Rev., 22: 365-367
2. Baxter, L. and Jain, R. (1989). Transport of fuid and macro-molecules in tumors. I. role of interstitial pressure and convection. Microvasc. Res., 37: 77-104
3. Baxter, L. and Jain, R. (1991a). Transport of fluid and macro-molecules in tumors. III. role of binding and metabolism. Microvasc. Res., 41: 5-23
4. Baxter, L. and Jain, R. (1991b). Transport of fluid and macro-molecules in tumors. IV. a microscopic model of the perivascular distribution. Microvasc. Res, 41: 252-272
5. Baxter, L. and Jain, R. (1996). Pharmacokinetics analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data. Br. J. Cancer, 73: 447-456
6. Baxter, L., Yuan, F., and Jain, R. (1992). Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. Cancer Res., 52: 5838-5844
7. Bosslet, K., Czech, J., and Hoffmann, D. (1994). Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res., 54: 2151-2159
8. Eccles, S., Court, W., Box, G., C. J., D., Melton, R, G., and Springer, C. (1994). Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erb-b2 p185. Cancer Res., 54: 5171-5177
9. Gerlowski, L. and Jain, R. (1986). Microvascular permeability of normal and neoplastic tissues. Microvasc. Res., 31: 288-305
10. Jackson, T. L., Lubkin, S. R., Siemers, N. O., Kerr, D. E., Senter, P. D., and Murray, J. D. (1999). Mathematical and experimental analysis of localization of anti-tumor antibody-enzyme conjugates. To appear Br. J. of Cancer
11. Kerr, D., Schreiber, G., Vrudhula, B., Svensson, H., Hellstrom, K., and Senter, P. (1995). Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anti-cancer prodrugs. Cancer Res., 55: 3558-3563
12. Krogh, A. (1919). The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J. of Physiol., 52: 409-415
13. Melton, R. and Sherwood, R. (1996). Antibody-enzyme conjugates for cancer therapy. J. Natl. Cancer Inst., 88: 153-165
14. Meyer, D., Jungheim, L., Law, K., Mikolajczyk, S., Shepherd, T., Mackensen, D., Briggs, S., and Starling, J. (1993). Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and long term growth inhibition of human colon carcinoma xenograft models. Cancer Res., 53: 3956-3963
15. Niculescu-Duvaz, I. and Springer, C. (1996). Antibody-directed enzyme prodrug therapy (ADEPT): A targeting strategy in cancer chemotherapy. Current Medicinal Chemistry, 2: 687-706
16. Nugent, L. and Jain, R. (1984). Extravascular diffusion in normal and neoplastic tissues. Cancer Res., 44: 238-244
17. O'Callaghan, D., Morris, A., Kriby, S., and Shingler, A. (1972). Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrobial Agents and Chemotherapy, 1: 283-288
18. Pietersz, G., Rowland, A., Smyth, M., and McKenzie, I. (1994). Chemoimmunoconjugates for the treatment of cancer. Adv. Immunol., 56: 301-387
19. Senter, P. and Svensson, H. (1997). A summary of monoclonal antibody-enzyme/ prodrug combinations. Adv. Drug Delivery Rev., 22: 341-349
20. Senter, P., Wallace, P., Svensson, H., Vrudhula V., Kerr, D., Hellstrom, I., and Hellstrom, K. (1993). Generation of cytotoxic agensts by targeted enzymes. Bioconjugate Chem., 4: 3-9
21. Siemers, N., Kerr, D., Yarnold, S., Stebbins, M., Vrudhula, V., Hellstrom, I., Hellstrom, K., and Senter, P. (1997). L49-sfv-β-lactamase, a single chain anti-p97 antibody fusion protein. Bioconjugate Chem., 8: 510-519
22. Springer, C., Bagshawe, K., Sharma, S., Searle, F., Boden, J., Antoniw, P., Burke, P., Rogers, G., Sherwood, R., and Melton, R. (1991). Abalation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds. Eur. J. Cancer, 27: 1361-1366
23. Svensson, H., Vrudhula, V., Emswier, J., MacMaster, J., Cosand, W., Wallace, P., and Senter, P. (1995). In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody β-lactamase conjugates. Cancer Res., 55: 2357-2365
24. Wallace, P., MacMaster, J., Smith, V., Kerr, D., Senter, P., and Cosand, W. (1994). Intratumoral generation of 5-fluorouracil medicated by an antibody-cytosine deaminase conjugate in combination with 5-fluorcytosine. Cancer Res., 54: 2719-2723