Synthesis of a novel class of chiral polyaromatic amide dendrimers bearing an amino acid derived C3-symmetric core

Tetrahedron Letters

Volumn 44, Issue 1, 2003, Pages 37-40

  Romagnoli, Barbara ^a   Harwood, Laurence M ^a   Hayes, Wayne ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Asymmetric catalysis; Chiral dendrimers; Garner aldehyde

Indexed keywords

AMIDE; AMINO ACID; DENDRIMER;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHEMICAL REACTION; CHIRALITY; ENANTIOMER; GAS CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 0037213341     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02518-2     Document Type: Article

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22. The first and second generation dendrimers were isolated in 75 and 55% yield, respectively. In contrast to the smaller dendrimers, isolation of the third generation dendrimer proved difficult (despite extensive chromatographic separation attempts) and therefore an approximate yield (30%) is reported. Problematic purifications involving structurally related polyamide dendrimers have also been documented in the literature by several other research groups (see Appelhans, D.; Komber, H.; Vogt, D.; Häussler, L.; Voit, B. I. Macromolecules 2000, 33, 9494-9503; Ishida, Y.; Jikei, M.; Kakimoto, M.-A. Macromolecules 2000, 33, 3202.).
23. The first and second generation dendrimers were isolated in 75 and 55% yield, respectively. In contrast to the smaller dendrimers, isolation of the third generation dendrimer proved difficult (despite extensive chromatographic separation attempts) and therefore an approximate yield (30%) is reported. Problematic purifications involving structurally related polyamide dendrimers have also been documented in the literature by several other research groups (see Appelhans, D.; Komber, H.; Vogt, D.; Häussler, L.; Voit, B. I. Macromolecules 2000, 33, 9494-9503; Ishida, Y.; Jikei, M.; Kakimoto, M.-A. Macromolecules 2000, 33, 3202.).