Sepsis syndrome stimulates proximal tubule cholesterol synthesis and suppresses the SR-B1 cholesterol transporter

Kidney International

Volumn 63, Issue 1, 2003, Pages 123-133

  Zager, Richard A ^a   Johnson, Ali C M ^a   Hanson, Sherry Y ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesteryl esters; Endotoxin; Free cholesterol; HMG CoA reductase; LDL receptor; Statins

Indexed keywords

ATORVASTATIN; CHOLESTEROL; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HOMEOSTASIS; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS;

EID: 0037213064     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00735.x     Document Type: Article

References (47)

1. Zager RA, Burkhart KM, Johnson A, Sacks B: Increased proximal tubular cholesterol content: Implications for cell injury and the emergence of acquired cytoresistance. Kidney Int 56:1788-1797, 1999
2. Zager RA, Kalhorn T: Changes in free and esterified cholesterol: Hallmarks of acute tubular injury and acquired cytoresistance. Am J Pathol 157:1007-1016, 2000
3. Zager RA, Johnson A, Anderson K, Wright S: Cholesterol ester accumulation: An immediate consequence of acute ischemic renal injury. Kidney Int 59:1750-1761, 2001
4. Zager RA, Andoh T, Bennett WM: Renal cholesterol accumulation: A durable response following acute and subacute renal insults. Am J Pathol 159:743-752, 2001
5. Zager RA, Johnson AC: Renal cortical cholesterol accumulation: An integral component of the systemic stress response. Kidney Int 60:2229-2310, 2001
6. Zager RA, Johnson A, Hanson S, Dela Rosa V: Altered cholesterol localization and caveolin expression during the evolution of acute renal failure. Kidney Int 61:1674-1683, 2002
7. Zager RA: Plasma membrane cholesterol: A critical determinant of cellular energetics and tubular resistance to attack. Kidney Int 58:193-205, 2000
8. Zager RA: P glycoprotein-mediated cholesterol cycling: A potentially important determinant of proximal tubular cell viability. Kidney Int 60:944-956, 2001
9. Zager RA, Shah VO, Shah HV, et al: The mevalonate pathway during acute tubular injury: Selected determinants and consequences. Am J Pathol 161:681-692, 2002
10. Honda N, Hishida A, Ikuma K, et al: Acquired resistance to acute renal failure. Kidney Int 31:1233-1238, 1987
11. Nath KA, Balla G, Vercellotti J, et al: Induction of heme oxygenase is a rapid protective response in rhabdomyolysis in the rat. J Clin Invest 90:267-270, 1992
12. Vogt BA, Shanley TP, Croatt A, et al: Glomerular inflammation induces resistance to renal injury. J Clin Invest 98:2139-2145, 1996
13. Hayes JM, Boonshaft B, Maher JF, et al: Resistance to glycerol-induced acute renal failure. Nephron 7:155-164, 1970
14. Elliott WC, Houghton DC, Gilbert DN, et al: Gentamicin nephrotoxicity. II. Definitions of conditions necessary to induce acquired insensitivity. J Lab Clin Med 100:513-525, 1982
15. Zager RA, Baltes LA, Sharma HM, Jurkowitz MS: Responses of the acute renal failure kidney to additional ischemic events. Kidney Int 47:689-701, 1984
16. 2 deprivation injury, possibly by inducing uremia. Kidney Int 45:1760-1768, 1994
17. Zager RA: Obstruction of proximal tubules initiates cytoresistance against hypoxic damage. Kidney Int 47:17628-17636, 1995
18. Zager RA: Heme protein induced tubular cytoresistance: Expression at the plasma membrane level. Kidney Int 47:1336-1345, 1995
19. Johnson WJ, Phillips MC, Rothblat GH: Lipoproteins and cellular cholesterol homeostasis (chapt 9), in Subcellular Biochemistry (vol 28), edited by Bittman R, New York, Plenum Press, 1997, pp 235-268
20. Ishibashi S, Brown M, Goldstein J, et al: Hypercholesterolemia in LDL receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92:883-893, 1993
21. Chen W, Silver DL, Smith JD, Tall AR: Scavenger receptor-B1 inhibits ATP-binding cassette transport 1-mediated cholesterol efflux in macrophages. J Biol Chem 275:30794-30800, 2000
22. Kellner-Weibel G, De la Llera-Moya M, Connelly MA, et al: Expression of scavenger receptor B1 in COS-7 cells alters cholesterol content and distribution. Biochemistry 39:221-229, 2000
23. De la Llera-Moya M, Rothblat GH, Connelly MA, et al: Scavenger receptor BI (SR-B1) mediates free cholesterol flux independently of HDL tethering to the cell surface. J Lipid Res 40:575-580, 1999
24. Azhar S, Luo Y, Medicherla S, Reaven E: Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of the low-density lipoprotein receptor function. J Cell Physiol 180:190-202, 1999
25. Zager RA, Prior RB: Gentamicin and Gram negative bacteremia: A synergism for the development of experimental nephrotoxic acute renal failure. J Clin Invest 78:196-204, 1986
26. Ryan MJ, Johnson G, Kirk J, et al: HK-2: An immortalized proximal tubule epithelial cell line from normal human kidney. Kidney Int 45:48-57, 1994
27. Istvan ES, Deisenhofer J: The structure of the catalytic portion of human HMG CoA reductase. (Review) Biochim Biophys Acta 1529:9-18, 2000
28. Kim DY, Stauffacher CV, Rodwell VW: Engineering of Sulfolobus solfataricus HMG CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation. Biochemistry 39:2269-2275, 2000
29. Asslan R, Pradines A, Pratx C, et al: Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells. Biochem Biophys Res Commun 260:699-706, 1999
30. Omkumar RV, Rodwell VW: Phosphorylation of Ser 871 impairs the function of His865 of Syrian hamster 3-hydroxy-3-methyl-CoA reductase. J Biol Chem 269:16862-16866, 1994
31. O'Donnell MP, Kasiske BL, Kim Y, et al: Lovastatin retards the progression of established glomerular disease in obese Zucker rats. Am J Kidney Dis 22:83-89, 1993
32. Harris KP, Purkerson ML, Yates J, Klahr S: Lovastatin ameliorates the development of glomerulosclerosis and uremia in experimental nephrotic syndrome. Am J Kidney Dis 15:16-23, 1990
33. Edwards PA, Tabor D, Kast HR, et al: Regulation of gene expression by SREBP and SCAP. Biochim Biophys Acta 1529:103-113, 2000
34. Shimano H: Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40:439-452, 2001
35. Nohturfft A, DeBose-Boyd RA, Scheek S, et al: Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci USA 96: 11235-11240, 1999
36. Brown MS, Goldstein JL: A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96:11041-11048, 1999
37. Etingin OR, Hajjar DP: Evidence for cytokine regulation of cholesterol metabolism in herpesvirus-infected arterial cell by the lipoxygenase pathway. J Lipid Res 31:299-305, 1990
38. Sehgal PB, Guo GG, Shah M, Patel K: Cytokine signaling: STATS in plasma membrane rafts. J Biol Chem 277:12067-12074, 2002
39. Diomede L, Albani D, Bianchi M, Salmona M: Endotoxin regulates the maturation of sterol regulatory element binding protein-1 through the induction of cytokines. Eur Cytokine Netw 12: 625-630, 2001
40. Kaul D: Molecular link between cholesterol, cytokines, and atherosclerosis. Molec Cell Biochem 219:65-71, 2001
41. Pomerantz KB, Hajjar DP, Levi R, Gross SS: Cholesterol enrichment of arterial smooth muscle cells upregulates cytokine-induced nitric oxide synthesis. Biochem Biophys Res Commun 191:103-109, 1993
42. Wang N, Silver DL, Philippe C, Tall AR: Specific binding of Apo-A-1, enhanced cholesterol efflux and altered plasma membrane morphology in cells expressing ABC1. J Biol Chem 275:33053-33058, 2000
43. Acton S, Rigotti A, Landschulz KT, et al: Identification of scavenger receptor SR-B1 as a high density lipoprotein receptor. Science 271:518-520, 1996
44. Lin G: Insights of high-density lipoprotein apolipoprotein-mediated lipid efflux from cells. Biochem Biophys Res Commun 291:727-731, 2002
45. Wang N, Weng W, Breslow JL, Tall AR: Scavenger receptor B1 (SR-B1) is upregulated in adrenal gland in apolipoprotein A-1 and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. J Biol Chem 271:21001-21004, 1996
46. Wang Y, Oram JF: Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1. J Biol Chem 277:5692-5697, 2002
47. Vogt BA, Alam J, Croatt AJ, et al: Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin. Lab Invest 72:474-483, 1995