Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells

European Neuropsychopharmacology

Volumn 13, Issue 1, 2003, Pages 53-56

  Kenis, Gunter ^a   Steinbusch, Harry ^a   De Baets, Marc ^a   Maes, Michael ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Antidepressant; cAMP; Depression; Second messenger

Indexed keywords

CYCLIC AMP; IMIPRAMINE; LIPOPOLYSACCHARIDE; PAROXETINE; PHYTOHEMAGGLUTININ;

ARTICLE; BLOOD ANALYSIS; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIDEPRESSIVE AGENTS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIPRAMINE; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; PAROXETINE; PHYTOHEMAGGLUTININS;

EID: 0037212745     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00125-6     Document Type: Article

References (14)

1. Benbernou N., Esnault S., Shin H.C., Fekkar H., Guenounou M. Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology. 91:1997;361-368.
2. Brooker G., Harper J.F., Terasaki W.L., Moylan R.D. Radioimmunoassay of cyclic AMP and cyclic GMP. Adv. Cyclic Nucleotide Res. 10:1979;1-33.
3. Edgar V.A., Sterin-Borda L., Cremaschi G.A., Genaro A.M. Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation. Eur. J. Pharmacol. 372:1999;65-73.
4. Kontny E., Ziolkowska M., Ryzewska A., Maslinski W. Protein kinase C-dependent pathway is critical for the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Cytokine. 11:1999;839-848.
5. Kubera M., Kenis G., Bosmans E., Scharpe S., Maes M. Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. Neuropsychopharmacology. 23:2000;89-98.
6. Kubera M., Lin A.-H., Kenis G., Bosmans E., Van Bockstaele D., Maes M. Anti-inflammatory effects of antidepressants through suppression of the Interferon-γ/Interleukin-10 production ratio. J. Clin. Psychopharmacol. 21:2001;199-206.
7. Maes M., Song C., Lin A.-h., Bonaccorso S., Kenis G., De Jongh R., Bosmans E., Scharpe S. Negative immunoregulatory effects of antidepressants: inhibition of interferon-γ and stimulation of interleukin-10 secretion. Neuropsychopharmacology. 20:1999;370-379.
8. Oksenberg D., Oksenberg J.R., Sakai K., Peroutka S.J., Steinman L. Cyclic adenosine 3′,5′-monophosphate metabolism in activated T-cell clones. Immunology. 67:1989;484-488.
9. Platzer C., Meisel C., Vogt K., Platzer M., Volk H.D. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Int. Immunol. 7:1995;517-523.
10. Shenker B.J., Gray I. Cyclic nucleotide metabolism during lymphocyte transformation. I. Enzymatic mechanisms in changes in cAMP and cGMP concentration in Balb/c mice. Cell. Immunol. 43:1979;11-22.
11. Steiner A.L., Parker C.W., Kipnis D.M. Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides. J. Biol. Chem. 247:1972;1106-1113.
12. Wang T., Sheppard J.R., Foker J.E. Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis. Science. 201:1978;155-157.
13. Xia Z., DePierre J.W., Nassberger L. Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells. Immunopharmacology. 34:1996;27-37.
14. Zidek Z. Adenosine-cyclic AMP pathways and cytokine expression. Eur. Cytokine Netw. 10:1999;319-328.