Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-γ and interleukin-10

Neuropsychopharmacology

Volumn 23, Issue 1, 2000, Pages 89-98

  Kubera, Marta ^a,b   Kenis, Gunter ^c   Bosmans, Eugene ^c   Scharpé, Simon ^d   Maes, Michael ^b,e,f  

^a Clinical Research Center for Mental Health of Antwerp   (Belgium)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c Eurogenetics   (Belgium)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e MAASTRICHT UNIVERSITY   (Netherlands)

^f IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

5 HT receptors; Antidepressants; Cell mediated immunity; Cytokines; Depression; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; ANTIDEPRESSANT AGENT; FENCLONINE; FLESINOXAN; FLUOXETINE; GAMMA INTERFERON; INTERLEUKIN 10; RITANSERIN; SEROTONIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ADULT; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; IMMUNOREGULATION; INFLAMMATION; LYMPHOCYTE; MALE; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

ADULT; ANALYSIS OF VARIANCE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; MALE; MIDDLE AGED; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0034047297     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00150-5     Document Type: Article

References (55)

1. Ameisen J.-C., Meade R., Askenase P.W. A new interpretation of the involvement of serotonin in delayed-type hypersensitivity. Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells J Immunol. 142:1989;3171-3179.
2. Diagnostic and Statistical Manual of Mental Disorders. 4th Ed:1994;American Psychiatric Association, Washington DC.
3. Arzt E., Costas M., Finkielman S., Nahmod V.E. Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes. Life Sci. 48:1991;2557-2562.
4. Aune T.M., McGrath K.M., Sarry T., Bombara M.P., Kelley K.A. Expression of 5HT1a receptors on activated human T cells. J Immunol. 151:1993;1175-1183.
5. Aune M.T., Golden H.W., McGrath K.M. Inhibitors of serotonin synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. J Immunol. 153:1994;489-498.
6. Baumann M.H., Mash D.C., Staley J.K. The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain. Clin Neurosci Neuropathol. 6:1995;2150-2152.
7. Benbernou N., Esnault S., Shin H.C.K., Fekkar H., Guenounou M. Differential regulation of IFN-γ, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology. 91:1997;361-368.
8. Bluthé R.M., Crestani F., Kelley K.W., Dantzer R. Mechanisms of the behavioral effects of interleukin 1. Ann NY Acad Sci. 650:1992;268-275.
9. Bonnet M., Lespinats G., Burtin C. Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and antigen. Cell Immunol. 83:1984;280-291.
10. Boranic M., Pericic D., Poljak-Blazi M., Sverko V., Marotti T. Suppression of immune response in rats by stress and drugs interfering with metabolism of serotonin. Ann NY Acad Sci. 496:1987;485-491.
11. Candore G., Di Lorenzo G., Melluso M., Cigna D., Colucci A.T., Modica M.A., Caruso C. Gamma-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmunity. 16:1993;275-280.
12. Cavaillon J.-M. Les Cytokines. 1996;Masson, Paris.
13. Cohen R.A.J., Zitnay K.M., Weisbrod R.M. Platelet-induced neurogenic coronary contraction due to accumulation of the false neurotransmitter, 5-hydroxytryptamine. Clin Invest. 75:1985;286-292.
14. Connor T.J., Leonard B.E. Depression, stress and immunological activation. The role of cytokines in depressive disorders Life Sci. 62:1998;583-606.
15. De Groote D., Zangerle P.F., Gevaert Y., Fassotte M.F., Beguin Y., Noizat-Pirenne F., Pirenne J., Gathy R., Lopez M., Dehart I., Igot D., Baudrihaye M., Delacroix D., Franchimont P. Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. Cytokine. 4:1992;239-248.
16. De Groote D., Gevaert Y., Lopez M., Gathy R., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Novel method for the measurement of cytokine production by one-stage procedure. J Immunol Meth. 9:1993;259-267.
17. Devoino L.V., Korovina L.S., Ilyutchenok R.Y. Influence of some drugs on the immune response. I. The effect of. 5-hydroxytryptophan,(iproniazid and reserpine on primary and secondary immune responses Eur J Pharmacol 4):1968;441-448.
18. Devoino L.V., Morozova N.B. Serotoninergic system in neuroimmunomodulation. Mechanism of inhibition Novera H.S. Neuroimmunomodulation, Proceedings of the First International Workshop, Bethesda, 27-30 November 1984. 1988;119-123 Gordon and Breach Sciences Publishers, New York.
19. Eliseeva L.S., Stefanovich L.E. Specific binding of serotonin by blood leukocytes and peritoneal cells in the mouse. Biokhimiia. 47:1982;810-813.
20. Essmann W.B. Serotonin distribution in tissue and fluids. Essmann W.B. Serotonin in Health and Disease, Vol. 1. 1978;85-91 Spectrum, New York.
21. Felten D.L., Cohen N., Ader R., Felten S.Y., Carlson S.L., Roszman T.L. Psychoneuroimmunology. Ader R., Felten D.L., Cohen N. Psychoneuroimmunology. 1991;1-26 Academic Press, San Diego.
22. Finocchiaro L.M.E., Arzt E.S., Fernandez-Castelo S., Criscuolo M., Finkielman S., Nahmod V.E. Serotonin and melatonin synthesis in peripheral blood mononuclear cells. Stimulation by interferon-g as part of an immunomodulatory pathway J Interferon Res. 8:1988;705-716.
23. Gershon R.K., Askenase P.W., Gershon M.D. Requirement for vasoactive amines for production of delayed-type hypersensitivity skin reactions. J Exp Med. 142:1975;732-747.
24. Hamik P., Peroutka S. mCPP interactions with neurotransmitter receptors in the human brain. Biol Psychiatry. 25:1989;569-575.
25. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 23:1960;56-61.
26. Hellestrand K., Czerkinsky C., Ricksten A., Jansson B., Asea A., Kylefjord H., Hermodsson S. Role of serotonin in the regulation of interferon-gamma production by human natural killer cells. J Interferon Res. 13:1993;33-38.
27. Jackson J.C., Cross R.J., Walker R.F. Influence of serotonin on the immune response. J Immunol. 54:1985;505-513.
28. Jahnova E. The effect of risperidone and ritanserin on human IgG and IgM synthesis in vitro. Physiol Res. 43:1994;27-31.
29. Katsikis P.D., Cohen S.B., Londei M., Feldmann M. Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-. 10(to IFN-gamma or IL-2 determnines their function. Intl Immunol 7):1995;1287-1294.
30. Kubera M., Maes M. Serotonin-immune interactions in major depression. Patterson P.H., Kordon C., Christen Y., Fondation I.P.S.E.N. Neuroimmune Interactions in Neurologic and Psychiatric Disorders. 1999;79-88 Springer Verlag, New York.
31. Lin A, Song C, Kenis G, Bosmans E, De Jongh R, Scharpe S, Maes M: The in vitro immunosuppressive effects of moclobemide. J Affect Disord (In press).
32. Maes M. The immune pathophysiology of major depression. Honig A, van Praag H (eds), Depression. Neurobiological, Psychopathological and Therapeutic Advances:1997;197-215 John Wiley, Chichester.
33. Maes M., Meltzer H.Y.M. The serotonin hypothesis of major depression. Bloom F., Kupfer D. Psychopharmacology. The Fourth Generation of Progress:1995;933-944 Raven Press, New York.
34. Maes M., Smith R., Scharpe S. The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology. 20:1995;111-116.
35. Maes M., Delanghe J., Ranjan R., Meltzer H.Y., Desnyder R., Cooreman W., Scharpe S. The acute phase protein response in schizophrenia, mania and major depression. Effects of psychotropic drugs Psychiatry Res. 66:1997;1-11.
36. Maes M., Song C., Lin A., De Jongh R., Van Gastel A., Kenis G., Bosmans E., De Meester I., Benoy I., Neels H., Demedts P., Janca A., Scharpe S., Smith R.S. The effects of psychological stress on humans. Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety Cytokine. 10:1998;313-318.
37. Maes M., Song C., Lin A.-H., Bonaccorso S., Kenis G., De Jongh R., Bosmans E., Scharpe S. Negative immunoregulatory effects of antidepressants. Inhibition of interferon-γ and stimulation of interleukin-10 secretion Neuropsychopharmacology. 20:1999;370-379.
38. Markstein R., Matsumoto M., Kohler C., Togashi H., Yoshioka M., Hoyer D. Pharmacological characterization of 5-HT receptors positively coupled to adenyl cyclase in the rat hippocampus. Naunyn Schiedebergs Arch Pharmacol. 359:1999;454-459.
39. Mossner R., Lesch K.-P. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun. 12:1998;249-271.
40. Murray P.J., Wang L., Onufryk C., Tepper R.I., Young R.A. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infections. J Immunol. 158:1997;315-321.
41. Nordlind K., Sundstrom E., Bondesson L. Inhibiting effect of serotonin antagonists on the proliferation of mercuric chloride stimulated human peripheral blood T lymphocytes. Intl Arch Allergy Immunol. 87:1992;105-108.
42. Platzer C., Meisel C., Vogt K., Platzer M., Volk H.D. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Intl Immunol. 7:1995;517.
43. Ptak W., Geba G.P., Askenase P.W. Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine. J Immunol. 146:1991;3929-3936.
44. Roszman T.L., Jackson J.C., Cross R.J., Titus M.J., Markesbery W.R., Brooks W.H. Neuroanatomic and neurotransmitter influences on immune function. J Immunol. 135:1985;769S-772S.
45. Schoeffter P., Hoyer D. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Do discriminatory 5-HT1B receptor ligands exist? Arch Pharmacol. 339:1989;675-683.
46. Seidel A., Arolt V., Hunstiger M., Rink L., Behnisch A., Kirchner H. Cytokine production and serum proteins in depression. Scand J Immunol. 41:1995;534-538.
47. Sluzewska A., Rybakowski J.K., Laciak M., Mackiewicz A., Sobieska M., Wiktorowicz K. Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann Acad Sci. 762:1995;474-476.
48. Spitzer R.L., Williams J.B.W., Gibbon M., First M.B. Structured Clinical Interview According to DSM-III-R. 1990;American Press, New York.
49. Sternberg E.M., Wedner H.J., Leung M.K., Parker C.W. Effect of serotonin (5-HT) and other monoamines on murine macrophages. Modulation of interferon-gamma induced phagocytosis J Immunol. 138:1987;4360-4365.
50. Xia Z., DePierre J.W., Nassberger L. Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells. Immunopharmacology. 34:1996;27-37.
51. Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Res. 711:1996;163-174.
52. Yirmiya R. Behavioral and psychological effects of immune activation. Implications for depression due to a general medical condition Curr Opin Psychiatry. 10:1997;470-476.
53. Young M.R.I., Kut J.L., Coogan M.P., Wright M.A., Young M.E., Matthews J. Stimulation of splenic T-lymphocyte function by endogenous serotonin and by low-dose exogenous serotonin. Immunology. 80:1993;395-400.
54. Young M.R.I., Matthews J.P. Serotonin regulation of T-cell subpopulations and of macrophage accessory function. Immunology. 84:1995;148-152.
55. Zangerle P.F., De Groote D., Lopez M., Meuleman R.J., Vrindts Y., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. II. Application to rheumatoid arthritis and osteoarthritis. Cytokine. 4:1992;568-575.