Membrane microviscosity modulates μ-opioid receptor conformational transitions and agonist efficacy

Journal of Neurochemistry

Volumn 73, Issue 1, 1999, Pages 289-300

  Emmerson, Paul J ^a,c   Clark, Mary J ^a   Medzihradsky, Fedor ^a   Remmers, Ann E ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Parke Davis   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cholesterol; Efficacy; Membrane fluidity; Opioid agonists; Opioid receptor

Indexed keywords

BUTORPHANOL; DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANOSINE TRIPHOSPHATE; MU OPIATE RECEPTOR; NALTREXONE; PETHIDINE; PROFADOL;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; DRUG PENETRATION; MEMBRANE PERMEABILITY; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; VISCOSITY;

ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL ESTERS; DIPRENORPHINE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; GLIOMA; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MEMBRANE FLUIDITY; NALBUPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; NEUROBLASTOMA; PROTEIN CONFORMATION; RATS; RECEPTORS, OPIOID, MU; SODIUM CHLORIDE; SUFENTANIL; TUMOR CELLS, CULTURED; VISCOSITY;

ANIMALIA;

EID: 0033000842     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730289.x     Document Type: Article

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