The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore

Mechanisms of Ageing and Development

Volumn 123, Issue 6, 2002, Pages 707-724

  Mather, Michael W ^a   Rottenberg, Hagai ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium release activated channel; Calcium signaling; Immunosenescence; Membrane potential; Mitochondrial permeability transition pore; Reactive oxygen species

Indexed keywords

CALCIUM; CYCLOSPORIN; CYCLOSPORIN DERIVATIVE; IONOMYCIN; IONOPHORE; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; T LYMPHOCYTE RECEPTOR;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ELECTRON TRANSPORT; FLUORESCENCE; MALE; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; T LYMPHOCYTE;

AGING; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; CYCLOSPORINE; FEMALE; FLAVIN-ADENINE DINUCLEOTIDE; FLUORESCENT DYES; IMMUNOLOGIC MEMORY; INTRACELLULAR MEMBRANES; ION CHANNELS; IONOMYCIN; IONOPHORES; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATION-REDUCTION; RHODAMINE 123; SPLEEN; SUPEROXIDES; T-LYMPHOCYTES;

EID: 0037204528     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00416-X     Document Type: Article

References (54)

1. Oxidants, antioxidants and the degenerative diseases of aging
2. Molecular mechanisms of immunosuppression
3. Aging, energy, and oxidative stress in neurodegenerative diseases
4. Mitochondria and cell death. Mechanistic aspects and methodological issues
5. 2+ homeostasis
6. Hydroperoxide metabolism in mammalian organs
7. The mitochondrial permeability transition pore is modulated by oxidative agents through both pyrimidine nucleotides and glutathione at two separate sites
8. 2+, calcineurin, and NF-AT
9. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria
10. Calcium oscillations increase the efficiency and specificity of gene expression
11. mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice
12. Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset
13. Improved four-color flow cytometry method using fluo-3 and triple immunofluoresence for analysis of intracellular calcium ion fluxes among mouse lymphe node B- T-lymphocyte subsets
14. Mitochondrial decay in hepatocytes from old rats: Membrane potential decline, heterogeneity and oxidants increase
15. Mitochondrial regulation of store-operated calcium signaling in T lymphocytes
16. Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes
17. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals
18. Mitochondrial damage induced by conditions of oxidative stress
19. Dietary restriction augments protection against induction of the mitochondrial permeability transition
20. Flow cytometric detection of mitochondrial dysfunction in subpopulations of human mononuclear cells
21. Gene expression profile of aging and its retardation by caloric restriction
22. Gene-expression profile of the ageing brain in mice
23. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
24. The role of mitochondria in the regulation of calcium influx into Jurkat cells
25. Mitochondrial permeability transition triggers lymphocyte apoptosis
26. 2+ influx in rat thymic lymphocytes
27. Aging; current concepts
28. Aging enhances the activation of the permeability transition pore in mitochondria
29. Antioxidants and immune response in aged persons: Overview of present evidence
30. The aging immune system: Primer and prospectus
31. Calcium signals in T lymphocytes from old mice
32. Differential sensitivity of virgin and memory T lymphocytes to calcium ionophores suggests a buoyant density separation method and a model for memory cell hyporesponsiveness to Con A
33. CD4 memory T cell levels predict life span in genetically heterogeneous mice
34. 2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane
35. Intracellular calcium dependence of gene expression in single T lymphocytes
36. Fluorescence methods to assess multidrug resistance in individual cells
37. The T cell in the ageing individual
38. 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria
39. Calcium uptake and membrane potential in mitochondria
40. Mitochondrial dysfunction in lymphocytes from old mice: Enhanced activation of the permeability transition
41. Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells
42. Calcium and organelles: A two-sided story
43. 2+ release to cyclosporine A and related compounds
44. 2+ signals in oligodendrocyte progenitors
45. The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia
46. Partial restoration of Con A-induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin
47. Fluorescence measurement and photochemical manipulation of cytosolic free calcium
48. Mitochondrial DNA mutations in human degenerative diseases and aging
49. Seminars in medicine of the Beth Israel Deaconess medical center. Caloric intake and aging
50. Increased function of P-glycoprotein in T lymphocyte subsets of aging mice
51. Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein
52. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
53. The mitochondrial permeability transition
54. Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes