Involvement of the protein kinase C pathway in thyrotropin-induced STAT3 activation in FRTL-5 thyroid cells

Molecular and Cellular Endocrinology

Volumn 194, Issue 1-2, 2002, Pages 77-84

  Park, Y J ^a,b   Park, E S ^a   Kim, M S ^a   Kim, T Y ^a   Lee, H S ^a   Lee, S ^c   Jang, I S ^d   Shong, M ^e   Park, D J ^a   Cho, Bo Youn ^a,b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Boramae Hospital   (South Korea)

^c Bundang Jesaeng Hospital   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Chungnam National University   (South Korea)

Author keywords

FRTL 5 cells; PKC; STAT3; TSH

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ANTIBODY; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAT3 PROTEIN; STAUROSPORINE; THYROTROPIN; THYROTROPIN RECEPTOR; DNA BINDING PROTEIN; STAT3 PROTEIN, RAT; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANTIBODY ISOLATION; ARTICLE; CHO CELL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCLEROMYXEDEMA; THYROID CELL; TRANSCRIPTION INITIATION; ANIMAL; CELL LINE; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; THYROID GLAND;

ANIMALS; CELL LINE; CYCLIC AMP; DNA-BINDING PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; PROTEIN KINASE C; RATS; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; THYROID GLAND; THYROTROPIN; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0037200679     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00185-5     Document Type: Article

References (43)

1. Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene. 19:2000;2607-2611.
2. Ali M.S., Sayeski P.P., Dirksen L.B., Hayzer D.J., Marrero M.B., Bernstein K.E. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J. Biol. Chem. 272:1997;23382-23388.
3. Allegeier A., Offermanns S., Van Sande J., Spicher K., Schultz G., Dumont J.E. The human thyrotropin receptor activates G-proteins Gs and Gq/11. J. Biol. Chem. 269:1994;13733-13735.
4. Bachrach L.K., Eggo M.C., Mak W.W., Burrow G.N. Phorbol esters stimulate growth and inhibit differentiation in cultured thyroid cells. Endocrinology. 116:1985;1603-1609.
5. Bromberg J., Darnell J.E. Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 19:2000;2468-2473.
6. Bromberg J.F., Wrzeszczynska M.H., Devgan G., Zhao Y., Pestell R.G., Albanese C., Darnell J.E. Jr. Stat3 as an oncogene. Cell. 98:1999;295-303.
7. Camps M., Carozzi A., Schnabel P., Scheer A., Parker P.J., Gierschik P. Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma subunits. Nature. 360:1992;684-686.
8. Ciullo I., Diez-Roux G., Di Domenico M., Migliaccio A., Avvedimento E.V. cAMP signaling selectively influences Ras effector pathways. Oncogene. 20:2001;1186-1192.
9. Corre I., Baumann H., Hermouet S. Regulation by Gi2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3. Oncogene. 18:1999;6335-6342.
10. Darnell J.E. Jr. STATs and gene regulation. Science. 277:1997;630-1635.
11. Franke B., van Triest M., de Bruijn K.M., van Willigen G., Nieuwenhuis H.K., Negrier C., Akkerman J.W., Bos J.L. Sequential regulation of the small GTPase Rap1 in human platelets. Mol. Cell. Biol. 20:2000;779-785.
12. Gao Z., Chen T., Weber M.J., Linden J. A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. Cross-talk between cyclic AMP and protein kinase C pathways. J. Biol. Chem. 274:1999;5972-5980.
13. Ginsberg J., Gupta S., Matowe W.C., Kline L., Brindley D.N. Activation of phospholipase D in FRTL-5 thyroid cells by forskolin and dibutyryl-cyclic adenosine monophosphate. Endocrinology. 138:1997;3645-3651.
14. Goi T., Shipitsin M., Lu Z., Foster D.A., Klinz S.G., Feig L.A. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. EMBO J. 19:2000;623-630.
15. Goretzki P.E., Frilling A., Simon D., Roeher H.D. Growth regulation of normal thyroids and thyroid tumors in man. Recent Results Cancer Res. 118:1990;48-63.
16. Ihle J.N. Cytokine receptor signalling. Nature. 377:1995;591-594.
17. Ivashkiv L.B. Cytokines and STATs: how can signals achieve specificity. Immunity. 3:1995;1-4.
18. Katz A., Wu D., Simon M.I. Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature. 360:1992;686-689.
19. Kim W.B., Cho B.Y., Park H.Y., Lee H.K., Kohn L.D., Tahara K., Koh C.S. Epitopes for thyroid-stimulating antibodies in Graves' sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment. J. Clin. Endocrinol. Metab. 81:1996;1758-1767.
20. Kim W.B., Chung H.K., Lee H.K., Kohn L.D., Tahara K., Cho B.Y. Changes in epitopes for thyroid-stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: therapeutic implications. J. Clin. Endocrinol. Metab. 82:1997;1953-1959.
21. Kim W.B., Chung H.K., Park Y.J., Park D.J., Tahara K., Kohn L.D., Cho B.Y. The prevalence and clinical significance of blocking thyrotropin receptor antibodies in untreated hyperthyroid Graves' disease. Thyroid. 10:2000;579-586.
22. Lamy F., Wilkin F., Baptist M., Posada J., Roger P.P., Dumont J.E. Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway. J. Biol. Chem. 268:1993;8398-8401.
23. Laugwitz K.L., Allgeier A., Offermanns S., Spicher K., Van Sande J., Dumont J.E., Schultz G. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. Proc. Natl. Acad. Sci. USA. 93:1996;116-120.
24. Liang H., Venema V.J., Wang X., Ju H., Venema R.C., Marrero M.B. Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. J. Biol. Chem. 274:1999;19846-19851.
25. Lombardi A., Veneziani B.M., Tramontano D., Ingbar S.H. Independent and interactive effects of tetradecanoyl phorbol acetate on growth and differentiation functions of FRTL5 cells. Endocrinology. 123:1988;1544-1552.
26. Marrero M.B., Schieffer B., Paxton W.G., Heerdt L., Berk B.C., Delafontaine P., Bernstein K.E. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 375:1995;247-250.
27. Medina D.L., Toro M.J., Santisteban P. Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E×cyclin-dependent kinase 2 complexes. J. Biol. Chem. 275:2000;15549-15556.
28. Miller M.J., Rioux L., Prendergast G.V., Cannon S., White M.A., Meinkoth J.L. Differential effects of protein kinase A on Ras effector pathways. Mol. Cell. Biol. 18:1998;3718-3726.
29. M'Rabet L., Coffer P.J., Wolthuis R.M., Zwartkruis F., Koenderman L., Bos J.L. Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. J. Biol. Chem. 274:1999;21847-21852.
30. Park E.S., Kim H., Suh J.M., Park S.J., You S.H., Chung H.K., Lee K.W., Kwon O.Y., Cho B.Y., Kim Y.K., Ro H.K., Chung J., Shong M. Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway. Mol. Endocrinol. 14:2000;662-670.
31. αo protein. Science. 287:2000;142-144.
32. Ram P.T., Iyengar R. G protein-coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene. 20:2001;1601-1606.
33. Schuringa J.J., Jonk L.J., Dokter W.H., Vellenga E., Kruijer W. Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components. Biochem. J. 347:2000;89-96.
34. Sellera L.A., Feniuk W., Hunphrey P.P., Lauder H. Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation. J. Biol. Chem. 274:1999;16423-16430.
35. Simon A.R., Vikis H.G., Stewart S., Fanburg B.L., Cochran B.H., Guan K.L. Regulation of STAT3 by direct binding to the Rac1 GTPase. Science. 290:2000;144-147.
36. Tahara K., Ban T., Minegishi T., Kohn L.D. Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients. Biochem. Biophys. Res. Commun. 179:1991;70-77.
37. Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., Akira S. Stat3 activation is responsible for IL-6-dependent T-cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:1998;4652-4660.
38. Taussig R., Gilman A.G. Mammalian membrane-bound adenylyl cyclases. J. Biol. Chem. 270:1995;1-4.
39. Tsygankova O.M., Saavedra A., Rebhun J.F., Quilliam L.A., Meinkoth J.L. Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol. Cell. Biol. 21:2001;1921-1929.
40. Turkson J., Bowman T., Adnane J., Zhang Y., Djeu J.Y., Sekharam M., Frank D.A., Holzman L.B., Wu J., Sebti S., Jove R. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol. Cell. Biol. 19:1999;7519-7928.
41. Uddin S., Lekmine F., Sharma N., Majchrzak B., Mayer I., Young P.R., Bokoch G.M., Fish E.N., Platanias L.C. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J. Biol. Chem. 275:2000;27634-27640.
42. Walsh D.A., Perkins J.P., Krebs E.G. An adenosine 3′,5′-monophosphate-dependant protein kinase from rabbit skeletal muscle. J. Biol. Chem. 243:1968;3763-3765.
43. Weiss S.J., Philp N.J., Grollman E.F. Iodide transport in a continuous line of cultured cells from rat thyroid. Endocrinology. 144:1984;1090-1098.