Behavioral and morphologic studies of the chronically compressed cauda equina: Experimental model of lumbar spinal stenosis in the rat

Spine

Volumn 24, Issue 9, 1999, Pages 845-851

  Yamaguchi, Kiyoshi ^a   Murakami, Masazumi ^a   Takahashi, Kazuhisa ^a   Moriya, Hideshige ^a   Tatsuoka, Hozumi ^a   Chiba, Tanemichi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Animal model; Electron microscopy; Paw withdrawal latencies to thermal stimuli; Treadmill tests

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDA EQUINA; CELL STRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; HISTOLOGY; NERVE FIBER DEGENERATION; NERVE FIBER REGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SPINAL CORD COMPRESSION; TREADMILL; WALKING;

ANIMALS; AXONS; BEHAVIOR, ANIMAL; CAUDA EQUINA; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EXERTION; FOLLOW-UP STUDIES; LAMINECTOMY; LUMBAR VERTEBRAE; MALE; NERVE COMPRESSION SYNDROMES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL STENOSIS; WALKING;

EID: 0033135225     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199905010-00003     Document Type: Article

References (29)

1. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988;33:87-107.
2. Bohlman HH, Bahniuk E, Field G, Raskulinecz G. Spinal cord monitoring of experimental incomplete cervical spinal cord injury: A preliminary report. Spine 1981;6:428-36.
3. Cornefjord M, Sato K, Olmarker K, Rydevik B, Nordborg C. A model for chronic nerve root compression studies: Presentation of a porcine model for controlled, slow-onset compression with analyses of anatomic aspects, compression onset rate, and morphologic and neurophysiologic effects. Spine 1997;22: 946-57.
4. Delamarter RB, Bohlman HH, Dodge LD, Biro C. Experimental lumbar spinal stenosis: Analysis of the cortical evoked potentials, microvasculature and histopathology. J Bone Joint Surg [Am] 1990;72:110-20.
5. Delamarter RB, Sherman JE, Carr JB. Cauda equina syndrome: Neurologic recovery following immediate, early, or late decompression. Spine 1991;16: 1022-9.
6. Dunham NW, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharmaceut Assoc 1957;46:208-9.
7. Garfin SR, Cohen MS, Massie JB, et al. Nerve-roots of the cauda equina: The effect of hypotension and acute graded compression on function. J Bone Joint Surg [Am] 1990;72:1185-92.
8. Greene EC. Anatomy of the Rat. Transactions of the American Philosophical Society. New York, London: Hafner Publishing Company, 1963:127-35.
9. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32:77-88.
10. Harman K, Katnick J, de la Torre JC. A quick and accurate line-sampling technique to quantify myelinated axons in peripheral nerve cross-sections. J Neurosci Methods 1991;38:107-10.
11. Iwamoto H, Kuwahara H, Matsuda H, Noriage A, Yamano Y. Production of chronic compression of the cauda equina in rats for use in studies of lumbar spinal canal stenosis. Spine 1995;20:2750-7.
12. Jones BJ, Roberts DJ. The quantitative measurement of motor incoordination in naive mice using an accelerating rotarod. J Pharm Pharmacol 1968;20: 302-4.
13. Kawakami M, Weinstein JN, Chatani K, Spratt KF, Meller ST, Gebhart GF. Experimental lumbar radiculopathy: Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine 1994;19:1795-802.
14. Kobayashi S, Yoshizawa H, Hachiya Y, Ukai T, Morita T. Vasogenic edema induced by compression injury to the spinal nerve root: Distribution of intravenously injected protein tracers and gadolinium-enhanced magnetic resonance imaging. Spine 1993;18:1410-24.
15. Konno S, Olmarker K, ByrÜd G, Rydevik B, Kikuchi S. Intermittent cauda equina compression: An experimental study of the porcine cauda equina with analyses of nerve impulse conduction properties. Spine 1995;20:1223-6.
16. Mackinnon SE, Dellon AL, Hudson AR, Hunter DA. Chronic nerve compression: An experimental model in the rat. Ann Plast Surg 1984;13:112-20.
17. Munger BL, Bennett GJ, Kajander KC. An experimental painful peripheral neuropathy due to nerve constriction: I. Axonal pathology in the sciatic nerve. Exp Neurol 1992;118:204-14.
18. O'Brien JP, Mackinnon SE, MacLean AR, Hudson AR, Dellon AL, Hunter DA. A model of chronic nerve compression in the rat. Ann Plast Surg 1987;19: 430-5.
19. Olmarker K, Rydevik B, Holm S. Edema formation in spinal nerve roots induced by experimental, graded compression: An experimental study on the pig cauda equina with special reference to differences in effects between rapid and slow onset of compression. Spine 1989;14:569-73.
20. Olmarker K, Holm S, Rydevik B. Importance of compression onset rate for the degree of impairment of impulse propagation in experimental compression injury of the porcine cauda equina. Spine 1990;15:416-9.
21. Rydevik BL, Pedowitz RA, Hargens AR, Swenson MR, Myers RR, Garfin SR. Effects of acute, graded compression on spinal nerve root function and structure: An experimental study on the pig cauda equina. Spine 1991;16:487-93.
22. Sato K, Olmarker K, Cornefjord M, Rydevik B, Kikuchi S. Effects of chronic nerve root compression on intra radicular blood flow: An experimental study in pigs. Neuro Orthop 1994;16:1-7.
23. Sato K, Konno S, Yabuki S, Mao GP, Olmarker K, Kikuchi S. A model for acute, chronic, and delayed graded compression of the dog cauda equina: Neurophysiologic and histologic changes induced by acute, graded compression. Spine 1995;20:2386-91.
24. Tarlov IM, Klinger H. Spinal cord compression studies: II. Time limits for recovery after acute compression in dogs. Arch Neurol Psychiatr 1954;71:271-90.
25. Toh E, Mochida J. Histologic analysis of the lumbosacral nerve roots after compression in young and aged rabbits. Spine 1997;22:721-6.
26. Watzman N, Barry H. Drug effects on motor coordination. Psychopharmacologia (Berl) 1968;12:414-23.
27. Yasuhara K, Murakami M, Takahashi K, Yamagata M, Moriya H. Chronic compression model of the cauda equina: Histological and electrophysiological study. J Orthop Science 1996;1:376-83.
28. Yoshizawa H, Kobayashi S, Kubota K. Effects of compression on intraradicular blood flow in dogs. Spine 1989;14:1220-5.
29. Yoshizawa H, Kobayashi S, Morita T. Chronic nerve root compression: Pathophysiologic mechanism of nerve root dysfunction. Spine 1995;20:397-407.