Bivalency of plasminogen monoclonal antibodies is required for plasminogen bridging to fibrin and enhanced plasmin formation

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1598, Issue 1-2, 2002, Pages 165-176

  Dominguez, Miguel ^a   Montes, Ramón ^a   Páramo, José Antonio ^a   Anglés Cano, Eduardo ^a  

^a INSERM   (France)

Author keywords

Biosensor analysis; Fibrin surface; Kringle domain; mAb bivalency; Plasminogen activation; Plasminogen binding

Indexed keywords

FIBRIN; LYSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PLASMINOGEN; PLASMIN; PLASMINOGEN; UNCLASSIFIED DRUG; PLASMINOGEN ACTIVATOR;

ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSENSOR; COMPLEX FORMATION; ENZYME KINETICS; FIBRINOLYSIS; ISOTHERM; KRINGLE DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; CELL SURFACE; CONTROLLED STUDY; ENZYME ANALYSIS; HUMAN; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CELL MEMBRANE; FACTOR XII; FIBRIN; FIBRINOLYSIS; FIBRONECTINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MODELS, MOLECULAR; PLASMIN; PLASMINOGEN; PROTEIN CONFORMATION; SURFACE PLASMON RESONANCE;

EID: 0037194392     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(02)00364-3     Document Type: Article

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