Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells

Molecules and Cells

Volumn 13, Issue 1, 2002, Pages 113-117

  Heo, Ho Jin ^a   Hong, Seong Chan ^a   Cho, Hong Yon ^a   Hong, Bumshik ^a   Kim, Hye Kyung ^b   Kim, Eun Ki ^c   Shin, Dong Hoon ^a  

^a Korea University   (South Korea)

^b Hanseo University   (South Korea)

^c Inha University   (South Korea)

Author keywords

Acetylcholinesterase; Alzheimer's Disease; Fiatoua villosa; Zeatin

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; PLANT EXTRACT; ZEATIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; FIATOUA VILLOSA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MEDICINAL PLANT; MOLECULAR WEIGHT; NONHUMAN; RAT; ANIMAL; CELL STRAIN; CHEMISTRY; CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM;

ANIMALIA; VILLOSA;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY; HUMANS; PC12 CELLS; PLANTS, MEDICINAL; RATS; ZEATIN;

EID: 0037187052     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Abdulaziz, A. A., Mohammad, A. K., Nigel, H. G., Abdullah, S. A., and Elaine, R. P. (1998) Kinetic of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Biochem. Biophys. Res. Commun. 248, 180-185.
2. Banowetz, G. M., Ammar, K., and Chen, D. D. (1999) Temperature effect on cytokinin accumulation and kernel mass in a dwarf wheat. Ann. Bot. 83, 303-307.
3. Bores, G. M., Huger, F. P., Petko, W., Mutlib, A. E., Camacho, R, Rush, D. K., Selk, D. E., Wolf, V., Kosley, R. W., Davis, L., and Vargas, H. M. (1996) Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. J. Pharmacol. Exp. Ther. 277, 728-738.
4. Broadwell, R. D. and Sofroniew, M. V. (1993) Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp. Neurol. 120, 245-263.
5. Brufani, M., Filocamo, L., Lappa, S., and Maggi, A. (1997) New acetylcholinesterase inhibitors. Drugs Fut. 22, 397-411.
6. Chemnitius, J. M., Haselmeye, K. H., Gonska, B. D., Kreuzer, H., and Zech, R. (1996) Indirect parasympathomimetic activity of metoclopramide: reversible inhibition of cholinesterases from human central nervous system and blood. Pharmacol. Res. 34, 65-72.
7. Coyle, J. T., Price, D. L., and Delong, M. R. (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 1184-1190.
8. Doctor, B. P., Toker, L., Roth, E., and Silman, I. (1987) Microliter assay for acetylcholinesterase. Anal. Biochem. 166, 399-403.
9. Dong-Hang, R., Hua, R., and Xi-Can, T. (1996) Huperzine A, a novel promising acetylcholinesterase inhibitor. NeuroReport 8, 97-101.
10. Elaine, P., Clive, B., Dean, S., Cheng, A., Johnson, M., Mckeith, I., Piggott, M., and Perry, R. (1998) Cholinergic systems in the human brain: psychopharmacology and psychosis. Alzheimer's Disease Review 3, 117-124.
11. Ellman, G. L., Courtney, K. D., Andres, V. Jr., and Featherstone, R. M. (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
12. Gasparin, L., Rasshi, M., Binetti, G., Trabucchi, M., Solerte, S. B., Alkon, D., Etcheberrigary, R., Gibson, G., Blass, J., Paoletti, R., and Govoin, S. (1998) Peripheral markers in testing pathophysiological hypothesis and diagnosing Alzheimer's Disease. FASEB J. 12, 17-34.
13. Giacobini, E., Mori, F., and Lai, C. C. (1996) The effect of cholinesterase inhibitors on the secretion of APPs from rat brain cortex. Ann. N.Y. Acad. Sci. 777, 393-398.
14. Heo, H. J., Yang, H. C., Cho, H. Y., Hong, B. S., Lim, S. T., Park, H. J., Kim, K. H., Kim, H. K., and Shin, D. H. (2000) Inhibitory effect of Artemisia asiatica alkaloids on acetyl-cholinesterase activity from rat PC12 cells. Mol. Cells 10, 253-262.
15. Hermann, A. M. M. (1997) Principles of therapeutics of galanthamine. Drugs of Today 33, 251-257.
16. Hugo, L. F., Ricardo, D. M., and Nibaldo, C. I. (1996) Tetrameric (G4) Acetylcholinesterase: structure, localization, and physiological regulation. J. Neurochem. 66, 1335-1346.
17. Kurt, H. and Jean-Luc, W. (1997) The search for biologically active secondary metabolites. Pestic. Sci. 51, 471-482.
18. Lee, R. K. K., Wurtman, R. J., Cox, A. J., and Nitsch, R. M. (1995) Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc. Natl. Acad. Sci. USA 92, 8083-8087.
19. Louis, J. N. and Michael, M. (1997) Will natural products remain an important source of drug research for the future? Curr. Opin. Biotech. 8, 708-712.
20. McGeer, P. L. and McGeer, E. G. (1995) Alzheimer's disease: arthritis of the brain? Drug News Perspect. 8, 80-83.
21. Michael, W. J. (1998) Pharmacology and clinical efficacy of cholinesterase inhibitors. Am. J. Health-Syst. Ph. 55, Suppl. 2, S22-S25.
22. Mohamed-Bassem, A. A., Shirley, J. G., and Bruce, D. H. (1987) Use of a 96-well microplate reader for measuring routine enzyme activities. Anal. Biochem. 166, 353-360.
23. Pacheco, G., Palacios-Esquivel, R., and Moss, D. E. (1995) Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase. J. Pharmacol. Exp. Ther. 274, 767-770.
24. Park, C. H., Kim, S. H., Choi, W., Lee, Y. J., Kim, J. S., Kang, S. S., and Suh, Y. H. (1996) Novel acetylcholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa. Planta Med. 62, 405-409.
25. Rieger, F., Shelanski, M. L., and Greene, L. A. (1980) The effects of nerve growth factor on acetylcholinesterase and its multiple forms in cultures of rat PC12 pheochromocytoma cells: increased total specific activity and appearance of the 16S molecular form. Dev. Biol. 76, 238-243.
26. Taylor, P. (1991) The cholinesterase. J. Biol. Chem. 266, 4025-4028.
27. Wanda, J. K., John, J. S., and Neal, R. C. (1999) Cholinesterase inhibitors: a therapeutic strategy for Alzheimer's disease. Ann. Pharmacother. 33, 441-450.
28. William, S. (1998) Promising agents for treating Alzheimer's disease. Am. J. Health-Syst. Ph. 55, Suppl. 2, S11-S16.
29. Younkin, S. G., Goodridge, B., Katz, J., Lockett, G., Nafziger, D., Usiak, M. F., and Younkin, L. H. (1986) Molecular forms of acetylcholinesterases in Alzheimer's Disease. Fed. Proc. 45, 2980-2988.