메뉴 건너뛰기




Volumn 34, Issue 1-2, 1996, Pages 65-72

Indirect parasympathomimetic activity of metoclopramide: Reversible inhibition of cholinesterases from human central nervous system and blood

Author keywords

Acetylcholinesterase; Anti emetic drugs; Cholinesterase; Inhibition kinetics; Metoclopramide; Parasympathomimetic activity; Prokinetic drugs; Reversible inhibitor

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ANTIEMETIC AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE; ERYTHROCYTE ENZYME; ISOENZYME; METOCLOPRAMIDE; PROKINETIC AGENT;

EID: 0030184038     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.9999     Document Type: Article
Times cited : (38)

References (46)
  • 1
    • 0017082371 scopus 로고
    • Metoclopramide: A review of its pharmacological properties and clinical use
    • 1. Pinder RM, Brogden RN, Sawyer PR, Speight TM, Avery GS. Metoclopramide: A review of its pharmacological properties and clinical use. Drugs 1976; 12: 81-131.
    • (1976) Drugs , vol.12 , pp. 81-131
    • Pinder, R.M.1    Brogden, R.N.2    Sawyer, P.R.3    Speight, T.M.4    Avery, G.S.5
  • 3
    • 0018842411 scopus 로고
    • Gastric motor abnormalities in diabetic and postvagotomy gastroparesis. Effect of metoclopramide and bethanechol
    • 3. Malagelada JR, Rees WDW, Mazzotta LJ, Go VLW. Gastric motor abnormalities in diabetic and postvagotomy gastroparesis. Effect of metoclopramide and bethanechol. Gastroenterology 1980; 78: 286-93.
    • (1980) Gastroenterology , vol.78 , pp. 286-293
    • Malagelada, J.R.1    Rees, W.D.W.2    Mazzotta, L.J.3    Go, V.L.W.4
  • 4
    • 0018828574 scopus 로고
    • The antiemetic activity of tetrahydrocannabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy
    • 4. Colls BM, Ferry DG, Gray AJ, Harvey VJ, McQueen EG. The antiemetic activity of tetrahydrocannabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy. New Zealand Med J 1980; 91: 449-51.
    • (1980) New Zealand Med J , vol.91 , pp. 449-451
    • Colls, B.M.1    Ferry, D.G.2    Gray, A.J.3    Harvey, V.J.4    McQueen, E.G.5
  • 5
    • 0003244431 scopus 로고
    • The use of metoclopramide (Maxlon) in hyperemesis gravidarum
    • 5. Singh MS, Lean TH. The use of metoclopramide (Maxlon) in hyperemesis gravidarum. Proc Obstet Gynaecol Soc Singapore 1970; 1: 43-7.
    • (1970) Proc Obstet Gynaecol Soc Singapore , vol.1 , pp. 43-47
    • Singh, M.S.1    Lean, T.H.2
  • 6
    • 0018378511 scopus 로고
    • Multiple receptors for dopamine
    • 6. Kebabian JW, Calne DB. Multiple receptors for dopamine. Nature 1979; 227: 93-6.
    • (1979) Nature , vol.227 , pp. 93-96
    • Kebabian, J.W.1    Calne, D.B.2
  • 7
    • 0026083233 scopus 로고
    • Metoclopramide, domperidone and dopamine in man: Actions and interactions
    • 7. MacDonald TM. Metoclopramide, domperidone and dopamine in man: actions and interactions. Eur J Clin Pharmacol 1991; 40: 225-30.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 225-230
    • MacDonald, T.M.1
  • 8
    • 0028107979 scopus 로고
    • Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro
    • 8. Buchheit KH, Buhl T. Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro. Eur J Pharmacol 1994; 262: 91-7.
    • (1994) Eur J Pharmacol , vol.262 , pp. 91-97
    • Buchheit, K.H.1    Buhl, T.2
  • 10
    • 0025283334 scopus 로고
    • 5-Hydroxytryptamine: New receptors and novel drugs for gastrointestinal motor disorders
    • 10. Costall B, Naylor RJ. 5-Hydroxytryptamine: New receptors and novel drugs for gastrointestinal motor disorders. Scand J Gastroenterol 1990; 25: 769-87.
    • (1990) Scand J Gastroenterol , vol.25 , pp. 769-787
    • Costall, B.1    Naylor, R.J.2
  • 11
    • 0022872448 scopus 로고
    • Stimulation of gastroduodenal motor activity: Dopaminergic and cholinergic modulation
    • 11. Schuurkes JAJ, Helsen LFM, Ghoos E. Stimulation of gastroduodenal motor activity: Dopaminergic and cholinergic modulation. Drug Dev Res 1985; 8: 233-41.
    • (1985) Drug Dev Res , vol.8 , pp. 233-241
    • Schuurkes, J.A.J.1    Helsen, L.F.M.2    Ghoos, E.3
  • 12
    • 0028040322 scopus 로고
    • Cisapride versus metoclopramide in the treatment of functional dyspepsia
    • 12. Fumagalli I, Hammer B. Cisapride versus metoclopramide in the treatment of functional dyspepsia. Scand J Gastroenterol 1994; 29: 33-7.
    • (1994) Scand J Gastroenterol , vol.29 , pp. 33-37
    • Fumagalli, I.1    Hammer, B.2
  • 13
    • 0018372666 scopus 로고
    • Effect of metoclopramide on guinea pig stomach. Critical dependence on intrinsic stores of acetylcholine
    • 13. Hay AM, Man WK. Effect of metoclopramide on guinea pig stomach. Critical dependence on intrinsic stores of acetylcholine. Gastroenterology 1979; 76: 492-8.
    • (1979) Gastroenterology , vol.76 , pp. 492-498
    • Hay, A.M.1    Man, W.K.2
  • 14
    • 0017155785 scopus 로고
    • The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro
    • 14. Okwuasaba FK, Hamilton JT. The effect of metoclopramide on intestinal muscle responses and the peristaltic reflex in vitro. Can J Physiol Pharmacol 1976; 54: 393-404.
    • (1976) Can J Physiol Pharmacol , vol.54 , pp. 393-404
    • Okwuasaba, F.K.1    Hamilton, J.T.2
  • 15
    • 0020069863 scopus 로고
    • Effect of metoclopramide in guinea-pig ileum longitudinal muscle: Evidence against dopamine-mediation
    • 15. Zar MA, Ebong OO, Bateman DN. Effect of metoclopramide in guinea-pig ileum longitudinal muscle: Evidence against dopamine-mediation. Gut 1982; 23: 66-70.
    • (1982) Gut , vol.23 , pp. 66-70
    • Zar, M.A.1    Ebong, O.O.2    Bateman, D.N.3
  • 16
    • 0019981037 scopus 로고
    • The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum
    • 16. Kilbinger H, Kruel R, Pfeuffer-Friederich I, Wessler I. The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum. Naunyn-Schmiedeberg's Arch Pharmacol 1982; 319: 231-8.
    • (1982) Naunyn-Schmiedeberg's Arch Pharmacol , vol.319 , pp. 231-238
    • Kilbinger, H.1    Kruel, R.2    Pfeuffer-Friederich, I.3    Wessler, I.4
  • 19
    • 0025122614 scopus 로고
    • Dose-dependent effect of metoclopramide on cholinesterases and suxamethonium metabolism
    • 19. Kao YJ, Tellez J, Turner DR. Dose-dependent effect of metoclopramide on cholinesterases and suxamethonium metabolism. Br J Anaesthesia 1990; 65: 220-4.
    • (1990) Br J Anaesthesia , vol.65 , pp. 220-224
    • Kao, Y.J.1    Tellez, J.2    Turner, D.R.3
  • 20
    • 0026527479 scopus 로고
    • Difference in the inhibition of plasma cholinesterase activity by antiemetic metoclopramide in humans and mice
    • 20. Rao SS, Kaveeshwar U, Mihra PK. Difference in the inhibition of plasma cholinesterase activity by antiemetic metoclopramide in humans and mice. Pharmazie 1992; 47: 66-7.
    • (1992) Pharmazie , vol.47 , pp. 66-67
    • Rao, S.S.1    Kaveeshwar, U.2    Mihra, P.K.3
  • 21
    • 0000728009 scopus 로고    scopus 로고
    • Agents affecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes
    • Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A, eds. New York: McGraw Hill
    • 21. Brunton LL. Agents affecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Goodman Gilman A, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw Hill, 1996: 917-49.
    • (1996) Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th Ed. , pp. 917-949
    • Brunton, L.L.1
  • 22
    • 0011318071 scopus 로고
    • Indirect parasympathomimetic activity (IPA) of class I antiarrhythmic drugs
    • 22. Chemnitius JM, Haselmeyer KH, Kreuzer H, Zech R. Indirect parasympathomimetic activity (IPA) of class I antiarrhythmic drugs. Pharmacol Res 1995; 31, Suppl: 73.
    • (1995) Pharmacol Res , vol.31 , Issue.SUPPL. , pp. 73
    • Chemnitius, J.M.1    Haselmeyer, K.H.2    Kreuzer, H.3    Zech, R.4
  • 23
    • 77957015600 scopus 로고
    • Methods of extraction of enzymes from animal tissues
    • 23. Morton RK. Methods of extraction of enzymes from animal tissues. Meth Enzymol 1955; 1: 156-72.
    • (1955) Meth Enzymol , vol.1 , pp. 156-172
    • Morton, R.K.1
  • 24
    • 0020515891 scopus 로고
    • Carboxylesterases in primate brain: Characterization of multiple forms
    • 24. Chemnitius JM, Zech R. Carboxylesterases in primate brain: Characterization of multiple forms. Int J Biochem 1983; 15: 1019-25.
    • (1983) Int J Biochem , vol.15 , pp. 1019-1025
    • Chemnitius, J.M.1    Zech, R.2
  • 25
    • 33644811612 scopus 로고
    • A new and rapid colorimetric determination of acetylcholinesterase activity
    • 25. Ellman GL, Cortney D, Andrews V, Featherstone FM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.
    • (1961) Biochem Pharmacol , vol.7 , pp. 88-95
    • Ellman, G.L.1    Cortney, D.2    Andrews, V.3    Featherstone, F.M.4
  • 26
    • 0001169176 scopus 로고
    • Acetylcholinesterase: Triethylammonium inhibition of deacetylation
    • 26. Krupka RM. Acetylcholinesterase: Triethylammonium inhibition of deacetylation. Biochemistry 1964; 3: 1749-54.
    • (1964) Biochemistry , vol.3 , pp. 1749-1754
    • Krupka, R.M.1
  • 27
    • 0011326547 scopus 로고
    • The mechanism of action of acetylcholinesterase: Substrate inhibition and the binding of inhibitors
    • 27. Krupka RM. The mechanism of action of acetylcholinesterase: Substrate inhibition and the binding of inhibitors. Biochemistry 1966; 6: 1983-6.
    • (1966) Biochemistry , vol.6 , pp. 1983-1986
    • Krupka, R.M.1
  • 34
    • 0024470466 scopus 로고
    • Neuromuscular relaxation by suxamethonium following treatment with histamine type II antagonists or metoclopramide
    • 34. Turner DR, Kao YJ, Bivona C. Neuromuscular relaxation by suxamethonium following treatment with histamine type II antagonists or metoclopramide. Br J Anaesthesia 1989; 63: 348-50.
    • (1989) Br J Anaesthesia , vol.63 , pp. 348-350
    • Turner, D.R.1    Kao, Y.J.2    Bivona, C.3
  • 35
    • 0021994578 scopus 로고
    • Effect of cholinergic agonists on muscle from rodent proximal and distal small intestine
    • 35. Novak TV, Harrington B. Effect of cholinergic agonists on muscle from rodent proximal and distal small intestine. Gastroenterology 1985; 88: 1118-25.
    • (1985) Gastroenterology , vol.88 , pp. 1118-1125
    • Novak, T.V.1    Harrington, B.2
  • 38
    • 0023794322 scopus 로고
    • Acetylcholinesterase and butyrylcholinesterase in the gut mucosal cells of various mammalian species: Distribution along the intestine and molecular forms
    • 38. Sine JP, Ferrand R, Colas B. Acetylcholinesterase and butyrylcholinesterase in the gut mucosal cells of various mammalian species: Distribution along the intestine and molecular forms. Comp Biochem Physiol 1988; 91C: 597-602.
    • (1988) Comp Biochem Physiol , vol.91 C , pp. 597-602
    • Sine, J.P.1    Ferrand, R.2    Colas, B.3
  • 39
    • 0011272336 scopus 로고
    • Cholinesterases of the tissues and sera of rabbits
    • 39. Koelle GB. Cholinesterases of the tissues and sera of rabbits. Biochem J 1953; 53: 217-26.
    • (1953) Biochem J , vol.53 , pp. 217-226
    • Koelle, G.B.1
  • 40
    • 0020619823 scopus 로고
    • Brain cholinesterases: Differentiation of target enzymes for toxic organophosphorus compounds
    • 40. Chemnitius JM, Haselmeyer KH, Zech R. Brain cholinesterases: Differentiation of target enzymes for toxic organophosphorus compounds. Biochem Pharmacol 1983; 32: 1693-9.
    • (1983) Biochem Pharmacol , vol.32 , pp. 1693-1699
    • Chemnitius, J.M.1    Haselmeyer, K.H.2    Zech, R.3
  • 41
    • 0026579359 scopus 로고
    • Cholinesterases of heart muscle. Characterization of multiple enzymes using kinetics of irreversible organophosphorus inhibition
    • 41. Chemnitius JM, Chemnitius GC, Haselmeyer KH, Kreuzer H, Zech R. Cholinesterases of heart muscle. Characterization of multiple enzymes using kinetics of irreversible organophosphorus inhibition. Biochem Pharmacol 1992; 43: 823-9.
    • (1992) Biochem Pharmacol , vol.43 , pp. 823-829
    • Chemnitius, J.M.1    Chemnitius, G.C.2    Haselmeyer, K.H.3    Kreuzer, H.4    Zech, R.5
  • 42
    • 0020687296 scopus 로고
    • Untersuchungen zur Pharmakokinetik und zur Bioäquivalenz unterschiedlicher oraler Formulierungen von Metoclopramid
    • 42. Vergin H, Bishop-Freudling GB, Strobel K, Reeves DS. Untersuchungen zur Pharmakokinetik und zur Bioäquivalenz unterschiedlicher oraler Formulierungen von Metoclopramid. Arzneim Forsch/Drug Res 1983; 33: 458-62.
    • (1983) Arzneim Forsch/Drug Res , vol.33 , pp. 458-462
    • Vergin, H.1    Bishop-Freudling, G.B.2    Strobel, K.3    Reeves, D.S.4
  • 43
    • 0026036312 scopus 로고
    • Continuous infusion of high-dose metoclopramide: Comparison of pharmacokinetically adjusted and standard doses for the control of cisplatin-induced acute emesis
    • 43. Brechot JM, Dupeyron JP, Delattre C, Chastang C, Laaban JP, Rochemaure J. Continuous infusion of high-dose metoclopramide: Comparison of pharmacokinetically adjusted and standard doses for the control of cisplatin-induced acute emesis. Eur J Clin Pharmacol 1991; 40: 283-6.
    • (1991) Eur J Clin Pharmacol , vol.40 , pp. 283-286
    • Brechot, J.M.1    Dupeyron, J.P.2    Delattre, C.3    Chastang, C.4    Laaban, J.P.5    Rochemaure, J.6
  • 44
    • 0021838389 scopus 로고
    • Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated smooth muscle
    • 44. Sanger GJ. Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated smooth muscle. J Pharm Pharmacol 1985; 37: 661-4.
    • (1985) J Pharm Pharmacol , vol.37 , pp. 661-664
    • Sanger, G.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.