Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity

European Journal of Pharmacology

Volumn 315, Issue 1, 1996, Pages

  Morisset, Séverine ^a   Traiffort, Elisabeth ^a   Schwartz, Jean Charles ^a  

^a CENTRE PAUL BROCA   (France)

Author keywords

Acetylcholinesterase; Histamine H3 receptor antagonist; Histamine N methyl transferase

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ALPHA METHYLHISTAMINE; HISTAMINE; HISTAMINE H3 RECEPTOR ANTAGONIST; HISTAMINE METHYLTRANSFERASE; TACRINE; THIOPERAMIDE;

ACETYLCHOLINE BRAIN LEVEL; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG MECHANISM; HISTAMINE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE ANTAGONISTS; HISTAMINE N-METHYLTRANSFERASE; MALE; METHYLHISTAMINES; MICE; NOOTROPIC AGENTS; PIPERIDINES; TACRINE;

EID: 0030574248     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00738-8     Document Type: Article

References (8)

1. Cumming, P., P.B. Reiner and S.R. Vincent, 1990, Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA), Biochem. Pharmacol. 40, 1345.
2. Freeman, S.E. and R.M. Dawson, 1991, Tacrine: a pharmacological review, Prog. Neurobiol. 36, 257.
3. Garbarg, M., H. Pollard, M.D. Trung Tuong, J.-C. Schwartz and C. Schwartz, 1989, Sensitive radioimmunoassays for histamine and telemethylhistamine in the brain, J. Neurochem. 53, 1724.
4. 3 antagonist, on the step-through passive avoidance response and histidine decarboxylase activity in senescence-accelerated mice, Pharmacol. Biochem. Behav. 50, 321.
5. Nishibori, M., R. Oishi, Y. Itoh and K. Saeki, 1991, 9-Amino-1,2,3,4-tetrahydroacridine is a potent inhibitor of histamine-N-methyltransferase, Jpn. J. Pharmacol. 55, 539.
6. Schwartz, J.-C., J.M. Arrang, M. Garbarg, H. Pollard and M. Ruat, 1991, Histaminergic transmission in the mammalian brain, Physiol. Rev. 71, 1.
7. Schwartz, J.-C., J.M. Arrang, M. Garbarg and E. Traiffort, 1995, Histamine, in: Psychopharmacology: The Fourth Generation of Progress, eds, F.E. Bloom and D.J. Kupfer (Raven Press, New York, NY) p. 595.
8. Thomsen, T., H. Kewitz and O. Pleul, 1989, A suitable method to monitor inhibition of cholinesterase activities in tissues as induced by reversible enzyme inhibitors, Enzyme 42, 219.