Novel potassium channel opener prodrugs with a slow onset and prolonged duration of action

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 4, 2000, Pages 490-495

  Horino, Haruhiko ^a   Mimura, Tetsuya ^a   Kobayashi, Syozo ^a   Ohta, Masahiro ^a   Kubo, Hideo ^a   Ito, Kuniko ^a   Tsumura, Mitsuyoshi ^a   Kitagawa, Masayuki ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

1 benzopyran; Diazabicyclo 4.1.0 heptene; Hypotensive activity; Potassium channel opener; Prodrug

Indexed keywords

4 (4 BENZYL 5 OXO 3,4 DIAZABICYCLO[4.1.0]HEPT 2 EN 2 YLOXY) 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H 1 BENZOPYRAN 6 CARBONITRILE; 4 (N ACETYL N HYDROXYAMINO) 6 CYANO 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN 3 OL; ADENOSINE TRIPHOSPHATE; CARBOXYMETHYLCELLULOSE; DRUG METABOLITE; LEMAKALIM; POTASSIUM CHANNEL STIMULATING AGENT; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; MALE; NONHUMAN; SPONTANEOUSLY HYPERTENSIVE RAT; TACHYCARDIA;

EID: 0034016531     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.490     Document Type: Article

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