MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage

Oncogene

Volumn 21, Issue 43, 2002, Pages 6649-6656

  Bild, Andrea H ^a   Mendoza, Francisco J ^c   Gibson, Erika M ^c   Huang, Mei ^b   Villanueva, Jacylyn ^c   Garrington, Timothy P ^a   Jove, Richard ^b   Johnson, Gary L ^a   Gibson, Spencer B ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Apoptosis; Caspases; Death receptors; MAPK; Serine threonine kinases; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; CASPASE; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DECOY RECEPTOR 1; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE OVEREXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CASPASES; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0037179867     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205819     Document Type: Article

References (36)

1. Ashkenazi A and Dixit VM. (1999). Curr. Opin. Cell Biol., 11, 255-260.
2. Asselin E, Mills GB and Tsang BK. (2001). Cancer Res., 61, 1862-1868.
3. Blume-Jensen P and Hunter T. (2001). Nature, 411, 355-365.
4. Cardone MH, Salvesen GS, Widmann C, Johnson G and Frisch SM. (1997). Cell, 90, 315-323.
5. Datta SR, Brunet A and Greenberg ME. (1999). Genes Dev., 13, 2905-2927.
6. Deak JC, Cross JV, Lewis M, Qian Y, Parrott LA, Distelhorst CW and Templeton DJ. (1998). Proc. Natl. Acad. Sci. USA, 95, 5595-5600.
7. Di Cristofano A, Kotsi P, Peng YF, Cordon-Cardo C, Elkon KB and Pandolfi PP. (1999). Science, 285, 2122-2125.
8. Faris M, Kokot N, Latinis K, Kasibhatla S, Green DR, Koretzky GA and Nel A. (1998a). J. Immunol., 160, 134-144.
9. Faris M, Latinis KM, Kempiak SJ, Koretzky GA and Nel A. (1998b). Mol. Cell. Biol., 18, 5414-5424.
10. Friesen C, Herr I, Krammer PH and Debatin KM. (1996). Nat. Med., 2, 574-577.
11. Gebauer G, Mirakhur B, Nguyen Q, Shore SK, Simpkins H and Dhanasekaran N. (2000). Int. J. Oncol., 16, 321-325.
12. Gibson S, Widmann C and Johnson GL. (1999). J. Biol. Chem., 274, 10916-10922.
13. Gibson SB, Oyer R, Spalding AC, Anderson SM and Johnson GL. (2000). Mol. Cell. Biol., 20, 205-212.
14. Golstein P. (1997). Curr. Biol., 7, R750-R753.
15. Green DR. (2000). Cell, 102, 1-4.
16. Griffith TS and Lynch DH. (1998). Curr. Opin. Immunol., 10, 559-563.
17. Gura T. (1997). Science, 277, 768.
18. Khwaja A. (1999). Nature, 401, 33-34.
19. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ and Johnson GL. (1993). Science, 260, 315-319.
20. Lee SH, Shin MS, Kim HS, Lee HK, Park WS, Kim SY, Lee JH, Han SY, Park JY, Oh RR, Kang CS, Kim KM, Jang JJ, Nam SW, Lee JY and Yoo NJ. (2001). Oncogene, 20, 399-403.
21. Lin H, Chen C and Chen BD. (2001). Biochem. J., 353, 299-306.
22. Mullauer L, Gruber P, Sebinger D, Buch J, Wohlfart S and Chott A. (2001). Mutat. Res., 488, 211-231.
23. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J and Dixit VM. (1997). Science, 276, 111-113.
24. Panka DJ, Mano T, Suhara T, Walsh K and Mier JW. (2001). J. Biol. Chem., 276, 6893-6896.
25. Schlesinger TK, Fanger GR, Yujiri T and Johnson GL. (1998). Front Biosci., 3, D1181-D1186.
26. Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P and Ashkenazi A. (1997). Science, 277, 818-821.
27. Shin MS, Kim HS, Lee SH, Park WS, Kim SY, Park JY, Lee JH, Lee SK, Lee SN, Jung SS, Han JY, Kim H, Lee JY and Yoo NJ. (2001). Cancer Res., 61, 4942-4946.
28. Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R and Weinstein IB. (2001). J. Biol. Chem., 276, 16406-16410.
29. Straus SE, Jaffe ES, Puck JM, Dale JK, Elkon KB, Rosen-Wolff A, Peters AM, Sneller MC, Hallahan CW, Wang J, Fischer RE, Jackson CM, Lin AY, Baumler C, Siegert E, Marx A, Vaishnaw AK, Grodzicky T, Fleisher TA and Lenardo MJ. (2001). Blood, 98, 194-200.
30. Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG and Kerbel RS. (1999). Biochem. Biophys. Res. Commun., 264, 781-788.
31. Tschopp J, Irmler M and Thome M. (1998). Curr. Opin. Immunol., 10, 552-558.
32. Widmann C, Gerwins P, Johnson NL, Jarpe MB and Johnson GL. (1998). Mol. Cell. Biol., 18, 2416-2429.
33. Widmann C, Gibson S, Jarpe MB and Johnson GL. (1999). Physiol. Rev., 79, 143-180.
34. Widmann C, Johnson NL, Gardner AM, Smith RJ and Johnson GL. (1997). Oncogene, 15, 2439-2447.
35. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW and Mak TW. (1998). Genes Dev., 12, 806-819.
36. Yujiri T, Sather S, Fanger GR and Johnson GL. (1998). Science, 282, 1911-1914.